N-(1-methoxy-2-methylprop-1-yl)-2-phenylacetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(1-methoxy-2-methylprop-1-yl)-2-phenylacetamide
• 英文别名: N-(1-methoxy-2-methylpropyl)-2-phenylacetamide
• 化学式: C₁₃H₁₉NO₂
• 分子量: 221.299
• InChiKey: ONXGJVBLHFXROU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(1-methoxy-2-methylprop-1-yl)-2-phenylacetamide 以 二氯甲烷 为溶剂， 反应 2.67h， 生成 N-[1-(2,4,6-trimethoxyphenyl)-2-methylpropyl]phenylacetamid
  参考文献：
  名称：

  1-（N-酰基氨基）烷基三芳基phosph盐与富电子芳烃的无催化剂Friedel-Crafts反应

  摘要：

  1-（N-酰基氨基）烷基三芳基phosph盐与芳烃或杂芳烃的Friedel-Crafts反应，不需要任何催化剂，提供了广泛的生物学意义上的N-（1-芳基烷基）酰胺或1-芳基烷基phosph盐的接触途径。对叶立德和phospho离子液体的化学非常感兴趣。取决于反应条件和底物结构，反应可以选择性地以高收率朝向上述每种产物进行。还考虑了上述转换的机械方面。

  DOI：

  10.1016/j.tet.2018.03.053
• 作为产物：
  描述：

  甲醇 、 N-phenylacetylvaline 在 silica gel-supported piperidine 作用下， 生成 N-(1-methoxy-2-methylprop-1-yl)-2-phenylacetamide
  参考文献：
  名称：

  1-（N-酰基氨基）烷基三芳基phosph盐与富电子芳烃的无催化剂Friedel-Crafts反应

  摘要：

  1-（N-酰基氨基）烷基三芳基phosph盐与芳烃或杂芳烃的Friedel-Crafts反应，不需要任何催化剂，提供了广泛的生物学意义上的N-（1-芳基烷基）酰胺或1-芳基烷基phosph盐的接触途径。对叶立德和phospho离子液体的化学非常感兴趣。取决于反应条件和底物结构，反应可以选择性地以高收率朝向上述每种产物进行。还考虑了上述转换的机械方面。

  DOI：

  10.1016/j.tet.2018.03.053

文献信息

• [EN] PROCESS FOR PRODUCING AMINO ACID DERIVATIVES<br/>[FR] PROCEDE DE PRODUCTION DE DERIVES D'ACIDES AMINES
  申请人：SOLVAY

  公开号：WO2004087638A1

  公开（公告）日：2004-10-14

  Process for producing amino acid derivatives, in which (a) an organic amine, the amino functionality of which is protected, or an α-amino acid, the amino functionality of which is protected, is subjected to an electrochemical reaction so as to form an amine which is activated in the α-position; (b) the activated amine is subjected to a reaction with a carbanionic reagent containing at least 3 carbon atoms and comprising an unsaturated group so as to form an unsaturated amine comprising an unsaturated group, the atom of the unsaturated group closest to the nitrogen being separated from the nitrogen by at least 2 carbon atoms; (c) the unsaturated amine is subjected to oxidation of the unsaturated group so as to form an amino acid derivative.

  生产氨基酸衍生物的过程，其中（a）将保护氨基官能团的有机胺或保护氨基官能团的α-氨基酸经电化学反应，形成在α位激活的胺；（b）将激活的胺与至少含有3个碳原子且包含不饱和基团的碳负离子试剂反应，形成含有不饱和基团的不饱和胺，最接近氮的不饱和基团原子与氮之间至少相隔2个碳原子；（c）将不饱和胺氧化，形成氨基酸衍生物。
• Process for producing amino acid derivatives
  申请人：Callens Roland

  公开号：US20060276673A1

  公开（公告）日：2006-12-07

  Process for producing amino acid derivatives, in which (a) an organic amine, the amino functionality of which is protected, or an α-amino acid, the amino functionality of which is protected, is subjected to an electrochemical reaction so as to form an amine which is activated in the α-position; (b) the activated amine is subjected to a reaction with a carbanionic reagent containing at least 3 carbon atoms and comprising an unsaturated group so as to form an unsaturated amine comprising an unsaturated group, the atom of the unsaturated group closest to the nitrogen being separated from the nitrogen by at least 2 carbon atoms; (c) the unsaturated amine is subjected to oxidation of the unsaturated group so as to form an amino acid derivative.
• Catalyst-free Friedel-Crafts reaction of 1-(N-acylamino)alkyltriarylphosphonium salts with electron-rich arenes
  作者：Jakub Adamek、Anna Węgrzyk、Monika Krawczyk、Karol Erfurt

  DOI：10.1016/j.tet.2018.03.053

  日期：2018.5

  Friedel-Crafts reaction of 1-(N-acylamino)alkyltriarylphosphonium salts with arenes or heteroarenes without the need for any catalyst provided access to a wide range of biologically interesting N-(1-arylalkyl)amides or 1-arylalkylphosphonium salts which can be of great interest in the chemistry of ylides and phosphonium ionic liquids. Depending on reaction conditions and substrate structure, the reaction

  1-（N-酰基氨基）烷基三芳基phosph盐与芳烃或杂芳烃的Friedel-Crafts反应，不需要任何催化剂，提供了广泛的生物学意义上的N-（1-芳基烷基）酰胺或1-芳基烷基phosph盐的接触途径。对叶立德和phospho离子液体的化学非常感兴趣。取决于反应条件和底物结构，反应可以选择性地以高收率朝向上述每种产物进行。还考虑了上述转换的机械方面。