ethyl N-phenylacetimidate | 19655-72-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl N-phenylacetimidate
• 英文别名: N-Pnenylacetimidsaeureaethylester；N-Phenylacetimidsaeure-ethylester；ethyl (1E)-N-phenylethanimidoate；ethyl N-phenylethanimidate
• CAS: 19655-72-2
• 化学式: C₁₀H₁₃NO
• 分子量: 163.219
• InChiKey: KOCKILNMGAJMNX-UHFFFAOYSA-N

物化性质

• 沸点：
  94.5 °C(Press: 12.5 Torr)
• 密度：
  0.986 g/cm3(Temp: 25 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  ethyl N-phenylacetimidate 在 二(氰基苯)二氯化钯 作用下， 以 氘代氯仿 为溶剂， 反应 0.5h， 生成 N-allyl-N-phenylacetamide
  参考文献：
  名称：

  Homogeneous catalysis. Transition-metal-catalyzed Claisen rearrangements

  摘要：

  DOI：

  10.1021/ja00293a041
• 作为产物：
  描述：

  在 2,2,6,6-四甲基哌啶 作用下， 以30%的产率得到ethyl N-phenylacetimidate
  参考文献：
  名称：

  Monomeric metaphosphate anion: reaction with carbonyl groups

  摘要：

  DOI：

  10.1021/ja00395a030

文献信息

• Transacylation of cephalosporin; isolation and reactions of the imidate esters
  作者：Toshinori Saito、Ken Nishihata、Syunzo Fukatsu

  DOI：10.1039/p19810001058

  日期：——

  The reaction of the imidate ester of methyl 7-acetamidoceph-3-em-4-carboxylate (2) and phenylacetyl chloride was followed by 13C n.m.r. spectroscopy, which disclosed the intermediacy of the adduct of (2) with the acyl chloride. Transacylations of methyl 7-([1-13C]acetamido)ceph-3-em-4-carboxylate (8) and methyl 7-±)-5-benzamido-5-methoxycarbonyl[1-13C]valeramido}ceph-3-em-4-carboxylate (9) were also

  13 C nmr光谱分析随后的是7-乙酰氨基二甲基-3-em-4-羧酸甲酯的亚氨酸酯和苯乙酰氯的反应，该光谱揭示了（2）的加合物与酰氯的中间体。7-（[[ 13 C]乙酰氨基）头孢-3-em-4-羧酸甲酯（8）和​​7- ±）-5-苯甲酰胺基-5-甲氧羰基甲基[1- 13 C]戊酰胺} ceph的酰基转移反应还发现-3-em-4-羧酸酯（9）是通过直接攻击相应的亚氨酸酯上的酰氯而进行的。
• Amidines. VIII. A kinetic study of alcoholysis of N1-arenesulfonyl-N1,N2-diarylacetamidines.
  作者：Machiko ONO、Reiko TODORIKI、Shinzo TAMURA

  DOI：10.1248/cpb.39.558

  日期：——

  Alcoholysis of N1-Arenesulfonyl-N1, N2-diarylacetamidines (1-30) was studied kinetically. The rate of the reaction between the substrates and ethoxide ion depended on the electron-withdrawing resonance effect of the substituents on both the N1-aryl and N2-aryl groups to a similar extent. The rate of the neutral alcoholysis depended on the resonance effect of the N1-aryl substituent to a larger extent than in the former reaction, and depended hardly at all on the electron-releasing resonance effect of the N2-aryl substituent, showing that the reaction does not proceed by the solvolysis mechanism.A reaction mechanism is proposed in which the rate-determining attack of the nucleophile is accompanied by the concerted departure of the N-arylarenesulfonamide group.

  对 N1-壬磺酰基-N1，N2-二芳基乙酰胺（1-30）的醇解进行了动力学研究。底物与乙氧离子的反应速率在类似程度上取决于 N1 芳基和 N2 芳基上取代基的吸电子共振效应。与前一种反应相比，中性醇解反应的速率在更大程度上取决于 N1-芳基取代基的共振效应，而几乎不取决于 N2-芳基取代基的电子释放共振效应，这表明该反应不是通过溶解机理进行的。
• Acaricidal trifluoromethyl-1,2,4-triazoles
  申请人：Commonwealth Scientific and Industrial Research Organization

  公开号：US04038405A1

  公开（公告）日：1977-07-26

  3-Trihalomethyl-1,2,4-triazoles either unsubstituted or having substituents in the 4 and/or 5, 1 and/or 5, and 2 and/or 5 positions; and methods for their preparation. Some of the compounds show biological activity; others have acaricidal activity.

  3-三卤甲基-1,2,4-三唑可以是未取代的，也可以在4和/或5，1和/或5，2和/或5位置上具有取代基;以及其制备方法。其中一些化合物表现出生物活性;其他具有杀螨活性。
• Triazoles
  申请人：Commonwealth Scientific and Industrial Research Organization

  公开号：US04049815A1

  公开（公告）日：1977-09-20

  3-Trihalomethyl-1,2,4-triazoles either unsubstituted or having substituents in the 4 and/or 5, 1 and/or 5, and 2 and/or 5 positions; and methods for their preparation. The compounds show biological activity; at least some have acaricidal activity.

  3-三卤甲基-1,2,4-三唑可以是未取代的，也可以在4和/或5，1和/或5，2和/或5位置具有取代基；以及它们的制备方法。这些化合物表现出生物活性；至少有些具有杀螨活性。
• Pilotti,A. et al., Acta Chemica Scandinavica (1947), 1969, vol. 23, p. 818 - 824
  作者：Pilotti,A. et al.

  DOI：——

  日期：——