4-aminomethyl-2-triethylsilyl-furan | 137552-73-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-aminomethyl-2-triethylsilyl-furan
• 英文别名: 2-triethylsilyl-4-aminomethylfuran；4-aminomethyl-2-triethylsilylfuran；(5-triethylsilylfuran-3-yl)methanamine
• CAS: 137552-73-9
• 化学式: C₁₁H₂₁NOSi
• 分子量: 211.379
• InChiKey: AEPMAYRDSIZIIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.45
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  39.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  月桂酰氯 、 4-aminomethyl-2-triethylsilyl-furan 、 乙醚 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 生成 4-(N-dodecanoylaminomethyl)-2-triethylsilylfuran
  参考文献：
  名称：

  Intermediates and processes for preparing 4-substituted 2-5(H)-furanones

  摘要：

  抗炎症的4-取代的2-呋喃酮是由具有以下结构的中间体制备的：##STR1## 其中R.sub.1，R.sub.2和R.sub.3独立地是1到6个碳原子的n-烷基，或者1到6个碳原子的支链烷基；X是H，OH，NH.sub.2，I或Br；R.sub.4是H，1-20个碳原子的烷基，苯基[C.sub.1-C.sub.20烷基]，萘基[C.sub.1-C.sub.20烷基]，CH.sub.2 OH，CH.sub.2 NH.sub.2，CH.sub.2 CH.sub.2 OH，CH.sub.2 --CHO，CH.sub.2 --COOH或CH.sub.2 --COOR.sub.5，而R.sub.5是1到6个碳原子的烷基，但当X为氢时，R.sub.4从CH.sub.2 OH，CH.sub.2 NH.sub.2，CH.sub.2 CH.sub.2 OH，CH.sub.2 --CHO或CH.sub.2 --COOR.sub.5的组中选择；##STR2## 其中R.sub.1，R.sub.2和R.sub.3独立地是1到6个碳原子的n-烷基，或者1到6个碳原子的支链烷基，而R.sub.5是1到6个碳原子的烷基；##STR3## 其中R.sub.1，R.sub.2和R.sub.3独立地是1到6个碳原子的n-烷基，或者1到6个碳原子的支链烷基，而R.sub.6是苯基，或者1到6个碳原子的烷基，以及##STR4## 其中R.sub.1，R.sub.2和R.sub.3独立地是1到6个碳原子的n-烷基，或者1到6个碳原子的支链烷基。

  公开号：

  US05082954A1
• 作为产物：
  描述：

  (E),(Z)-O-methyl-2-triethylsilyl-4-furaldehyde oxime 以 四氢呋喃 为溶剂， 生成 4-aminomethyl-2-triethylsilyl-furan
  参考文献：
  名称：

  Intermediates and processes for preparing 4-substituted 2-5(H)-furanones

  摘要：

  抗炎症的4-取代的2-呋喃酮是由具有以下结构的中间体制备的：##STR1## 其中R.sub.1，R.sub.2和R.sub.3独立地是1到6个碳原子的n-烷基，或者1到6个碳原子的支链烷基；X是H，OH，NH.sub.2，I或Br；R.sub.4是H，1-20个碳原子的烷基，苯基[C.sub.1-C.sub.20烷基]，萘基[C.sub.1-C.sub.20烷基]，CH.sub.2 OH，CH.sub.2 NH.sub.2，CH.sub.2 CH.sub.2 OH，CH.sub.2 --CHO，CH.sub.2 --COOH或CH.sub.2 --COOR.sub.5，而R.sub.5是1到6个碳原子的烷基，但当X为氢时，R.sub.4从CH.sub.2 OH，CH.sub.2 NH.sub.2，CH.sub.2 CH.sub.2 OH，CH.sub.2 --CHO或CH.sub.2 --COOR.sub.5的组中选择；##STR2## 其中R.sub.1，R.sub.2和R.sub.3独立地是1到6个碳原子的n-烷基，或者1到6个碳原子的支链烷基，而R.sub.5是1到6个碳原子的烷基；##STR3## 其中R.sub.1，R.sub.2和R.sub.3独立地是1到6个碳原子的n-烷基，或者1到6个碳原子的支链烷基，而R.sub.6是苯基，或者1到6个碳原子的烷基，以及##STR4## 其中R.sub.1，R.sub.2和R.sub.3独立地是1到6个碳原子的n-烷基，或者1到6个碳原子的支链烷基。

  公开号：

  US05082954A1

文献信息

• Pharmaceutical compositions and method for administering 3 and
  申请人：Allergan, Inc.

  公开号：US05268387A1

  公开（公告）日：1993-12-07

  3 and 4-substituted 2(5H)-furanone compounds influence the balance between bone production and bone resorption in mammals, including humans. The active compounds are administered to mammals, including humans, in an effective dose which ranges between 0.05 to 100 mg per kilogram, body weight, per day, for the purpose of influencing the balance between bone production and bone resorption, and particularly for treating osteoporosis.

  3和4-取代的2(5H)-呋喃酮化合物影响哺乳动物，包括人类的骨生成和骨吸收之间的平衡。这些活性化合物以有效剂量（每公斤体重范围在0.05至100毫克之间）被用于哺乳动物，包括人类，旨在影响骨生成和骨吸收之间的平衡，特别用于治疗骨质疏松症。
• 4-(oxygen, sulfur or nitrogen substituted)-methyl
  申请人：Allergan, Inc.

  公开号：US05037811A1

  公开（公告）日：1991-08-06

  Compounds of the formula ##STR1## in which R.sub.1 is H or alkyl of 1 to 20 carbons, CO--R.sub.1.sup.* CO--O--R.sub.1.sup.* CO--NH--R.sub.1.sup.* or PO(OR.sub.1.sup.*).sub.2 or PO(OR.sub.1.sup.*)R.sub.1.sup.* where R.sub.1.sup.* independently is H, alkyl of 1 to 20 carbons, phenyl, or substituted phenyl; X is O, S, SO--, SO.sub.2, NH--, or NR.sub.2 where R.sub.2 is phenyl, substituted phenyl or alkyl of 1 to 20 carbons, and Y is alkyl having at least 6 carbon atoms, arylalkyl, aryl, substituted aryl, substituted arylalkyl, alkenyl containing one or more olephinic bonds and at least 6 carbon atoms, CO--R.sub.3, CO--OR.sub.3, CONHR.sub.3, SO.sub.2 R.sub.3, SO.sub.2 NHR.sub.3 where R.sub.3 is aryl, substituted aryl, substituted arylalkyl, alkyl, alkenyl containing one or more olephinic bonds, further Y is (CH.sub.2).sub.n --O--R.sub.4, or (CH.sub.2).sub.n --O--(CH.sub.2).sub.m --O--R.sub.4, where n, and m, are integers and are independently 1 to 25 and R.sub.4 is phenyl, substituted phenyl or alkyl of one to 20 carbons, still further Y is PO(OH).sub.2, PO(OH)OR.sub.5, PO(OH)R.sub.5 PO(OR.sub.5).sub.2, where R.sub.5 is independently phenyl, substituted phenyl, alkyl or 1 to 20 carbons or R.sub.5 is (CH.sub.2).sub.n --N(R.sub.5.sup.*).sub.3 where R.sub.5.sup.* is alkyl of 1 to 20 carbons, or Y is NH--R.sub.6 where R.sub.6 is phenyl, substituted phenyl or alkyl of at least 6 carbon atoms with the proviso that when X is O, S, then Y is not NH--R.sub.6, and with the further proviso that when X is SO or SO.sub.2 then Y is not SO.sub.2 R.sub.3 or SO.sub.2 NHR.sub.3, are disclosed. The compounds possess anti-inflammatory activity.

  式为##STR1##的化合物，其中R.sub.1为H或含有1至20个碳原子的烷基，CO--R.sub.1.sup.* CO--O--R.sub.1.sup.* CO--NH--R.sub.1.sup.*或PO(OR.sub.1.sup.*).sub.2或PO(OR.sub.1.sup.*)R.sub.1.sup.*，其中R.sub.1.sup.*独立地为H、含有1至20个碳原子的烷基、苯基或取代苯基；X为O、S、SO--、SO.sub.2、NH--或NR.sub.2，其中R.sub.2为苯基、取代苯基或含有1至20个碳原子的烷基，Y为至少含有6个碳原子的烷基、芳基烷基、芳基、取代芳基、取代芳基烷基、含有一个或多个烯烃键且至少含有6个碳原子的烯烃基、CO--R.sub.3、CO--OR.sub.3、CONHR.sub.3、SO.sub.2 R.sub.3、SO.sub.2 NHR.sub.3，其中R.sub.3为芳基、取代芳基、取代芳基烷基、烷基、含有一个或多个烯烃键的烯烃基，进一步Y为(CH.sub.2).sub.n --O--R.sub.4，或(CH.sub.2).sub.n --O--(CH.sub.2).sub.m --O--R.sub.4，其中n和m为整数，独立地为1至25，R.sub.4为苯基、取代苯基或含有1至20个碳原子的烷基，进一步Y为PO(OH).sub.2、PO(OH)OR.sub.5、PO(OH)R.sub.5 PO(OR.sub.5).sub.2，其中R.sub.5独立地为苯基、取代苯基、含有1至20个碳原子的烷基，或R.sub.5为(CH.sub.2).sub.n --N(R.sub.5.sup.*).sub.3，其中R.sub.5.sup.*为含有1至20个碳原子的烷基，或Y为NH--R.sub.6，其中R.sub.6为苯基、取代苯基或至少含有6个碳原子的烷基，但其中X为O、S时，Y不是NH--R.sub.6，且当X为SO或SO.sub.2时，Y不是SO.sub.2 R.sub.3或SO.sub.2 NHR.sub.3，这些化合物具有抗炎活性。
• Di-(5-hydroxy-2(5H)-2-oxo-4-furyl)methyl-alpha,omega alkane-dioates and
  申请人：Allergan, Inc.

  公开号：US05171864A1

  公开（公告）日：1992-12-15

  Compounds of the formula ##STR1## in which R.sub.1 independently is H or alkyl of 1 to 20 carbons, CO--R.sub.2, CO--O--R.sub.2, CO--NH--R.sub.2, or PO(OR.sub.2).sub.2 or PO(OR.sub.2)R.sub.2, where R.sub.2 independently is H, alkyl of 1 to 20 carbons, phenyl, or lower alkyl substituted phenyl or halogen substituted phenyl; A is (CH.sub.2).sub.n where n ranges between 5 to 30, or A is a a divalent branch chained alkyl radical, or cycloalkyl radical, having a total of 5 to 30 carbons, and X is O or NH, have anti-inflammatory activity.

  式为##STR1##的化合物中，其中R.sub.1独立地为H或1至20个碳的烷基，CO--R.sub.2，CO--O--R.sub.2，CO--NH--R.sub.2，或PO(OR.sub.2).sub.2或PO(OR.sub.2)R.sub.2，其中R.sub.2独立地为H，1至20个碳的烷基，苯基，或取代苯基的低烷基或卤素取代苯基；A为(CH.sub.2).sub.n，其中n范围在5到30之间，或A为一种二价的分支链烷基基团，或环烷基基团，总共有5到30个碳，X为O或NH，具有抗炎活性。
• Intermediates for preparing 4-substituted 2-5(H)-furanones as
  申请人：Allergan, Inc.

  公开号：US05171863A1

  公开（公告）日：1992-12-15

  Anti-inflammatory 4-substituted 2-furanones are made from intermediates having the formulas: ##STR1## in which R.sub.1, R.sub.2 and R.sub.3 independently are n-alkyl of 1 to 6 carbons, or branched chain alkyl of 1 to 6 carbons; X is H, OH, NH.sub.2, I or Br; R.sub.4 is H, alkyl of 1-20 carbons, phenyl[C.sub.1 -C.sub.20 alkyl], naphthyl[C.sub.1 -C.sub.20 alkyl], CH.sub.2 OH, CH.sub.2 NH.sub.2, CH.sub.2 CH.sub.2 OH, CH.sub.2 --CHO, CH.sub.2 --COOH or CH.sub.2 --COOR.sub.5, and R.sub.5 is alkyl of 1 to 6 carbons, with the proviso that when X is hydrogen then R.sub.4 is selected from the group consisting of CH.sub.2 OH, CH.sub.2 NH.sub.2, CH.sub.2 CH.sub.2 OH, CH.sub.2 --CHO, or CH.sub.2 --COOR.sub.5 ; ##STR2## in which R.sub.1, R.sub.2 R.sub.3 independently are n-alkyl of 1 to 6 carbons, or branched chain alkyl of 1 to 6 carbons, and R.sub.5 is alkyl of 1 to 6 carbons; ##STR3## in which R.sub.1, R.sub.2 and R.sub.3 independently are n-alkyl of 1 to 6 carbons, or branched chain alkyl of 1 to 6 carbons, and R.sub.6 is phenyl, or alkyl of 1 to 6 carbons, and ##STR4## in which R.sub.1, R.sub.2 and R.sub.3 independently are n-alkyl of 1 to 6 carbons, or branched chain alkyl of 1 to 6 carbons.

  抗炎4-取代2-呋喃酮是由中间体制备而成，其化学式如下：##STR1## 其中，R.sub.1、R.sub.2和R.sub.3独立地是1到6个碳的n-烷基，或者是1到6个碳的支链烷基；X是H、OH、NH.sub.2、I或Br；R.sub.4是H、1-20个碳的烷基、苯基[C.sub.1-C.sub.20烷基]、萘基[C.sub.1-C.sub.20烷基]、CH.sub.2 OH、CH.sub.2 NH.sub.2、CH.sub.2 CH.sub.2 OH、CH.sub.2 --CHO、CH.sub.2 --COOH或CH.sub.2 --COOR.sub.5，其中R.sub.5是1到6个碳的烷基，但是当X是氢时，R.sub.4的选择范围包括CH.sub.2 OH、CH.sub.2 NH.sub.2、CH.sub.2 CH.sub.2 OH、CH.sub.2 --CHO或CH.sub.2 --COOR.sub.5；##STR2## 其中，R.sub.1、R.sub.2和R.sub.3独立地是1到6个碳的n-烷基，或者是1到6个碳的支链烷基，而R.sub.5是1到6个碳的烷基；##STR3## 其中，R.sub.1、R.sub.2和R.sub.3独立地是1到6个碳的n-烷基，或者是1到6个碳的支链烷基，而R.sub.6是苯基或1到6个碳的烷基；##STR4## 其中，R.sub.1、R.sub.2和R.sub.3独立地是1到6个碳的n-烷基，或者是1到6个碳的支链烷基。
• 2-trialkylsilyl-3-furaldehydes
  申请人：Allergan, Inc.

  公开号：US05322953A1

  公开（公告）日：1994-06-21

  Anti-inflammatory 4-substituted 2-furanones are made from intermediates having the formula ##STR1## where R.sub.1, R.sub.2 and R.sub.3 independently are n-or branched chain alkyl of 1 to 6 carbons. These compounds can be used as intermediates to produce 4-substituted 2-furanones which are anti-inflammatory agents.

  抗炎4-取代的2-呋喃酮是由具有以下公式的中间体制备的：##STR1## 其中R.sub.1、R.sub.2和R.sub.3分别是1至6个碳原子的n-或支链烷基。这些化合物可用作中间体，以生产具有抗炎作用的4-取代的2-呋喃酮。