2-(2-hydroxyphenyl)-6-methyl-4(3H)-quinazolinone | 88220-45-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-(2-hydroxyphenyl)-6-methyl-4(3H)-quinazolinone
• 英文别名: 2-(2-Hydroxyphenyl)-6-methylquinazolin-4(1H)-one；2-(2-hydroxyphenyl)-6-methyl-3H-quinazolin-4-one
• CAS: 88220-45-5
• 化学式: C₁₅H₁₂N₂O₂
• 分子量: 252.272
• InChiKey: DNVOEANLAVLCKO-UHFFFAOYSA-N

物化性质

• 熔点：
  322.5-324.0 °C(Solv: 1-butanol (71-36-3))
• 沸点：
  467.4±55.0 °C(Predicted)
• 密度：
  1.31±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  61.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  邻羟基苯甲腈 在 三乙胺 作用下， 以 二苯醚 、 甲苯 为溶剂， 反应 21.0h， 生成 2-(2-hydroxyphenyl)-6-methyl-4(3H)-quinazolinone
  参考文献：
  名称：

  Petridou-Fischer, J.; Papadopoulos, E. P., Journal of Heterocyclic Chemistry, 1983, vol. 20, p. 1159 - 1167

  摘要：

  DOI：

文献信息

• PETRIDOU-FISCHER, J.;PAPADOPOULOS, E. P., J. HETEROCYCL. CHEM., 1983, 20, N 5, 1159-1167
  作者：PETRIDOU-FISCHER, J.、PAPADOPOULOS, E. P.

  DOI：——

  日期：——
• PROCESSES FOR PRODUCING 4-AMINOQUINAZOLINES
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：EP1828150A2

  公开（公告）日：2007-09-05
• METHODS FOR TUMOR DIAGNOSIS AND THERAPY
  申请人：Kassis Amin I.

  公开号：US20090285755A1

  公开（公告）日：2009-11-19

  The present invention discloses a method for the enzyme-mediated, site-specific, in-vivo precipitation of a water soluble molecule in an animal. The enzyme is either unique to tumor cells, or is produced within a specific site (e.g., tumor) at concentrations that are higher than that in normal tissues. Alternatively, the enzyme is conjugated to a targeting moiety such as an antibody or a receptor-binding molecule.
• Methods for Tumor Diagnosis and Therapy
  申请人：President and Fellows of Harvard College

  公开号：US20160158390A1

  公开（公告）日：2016-06-09

  The present invention discloses a method for the enzyme-mediated, site-specific, in-vivo precipitation of a water soluble molecule in an animal. The enzyme is either unique to tumor cells, or is produced within a specific site (e.g., tumor) at concentrations that are higher than that in normal tissues. Alternatively, the enzyme is conjugated to a targeting moiety such as an antibody or a receptor-binding molecule.
• US7514067B2
  申请人：——

  公开号：US7514067B2

  公开（公告）日：2009-04-07