3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2-(prop-2-ynyloxymethyl)-2H-1-benzopyran | 1333118-59-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2-(prop-2-ynyloxymethyl)-2H-1-benzopyran
• 英文别名: 3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2-(prop-2-ynyloxymethyl)-2Η-1-benzopyran；6-Methoxy-2,5,7,8-tetramethyl-2-(prop-2-ynoxymethyl)-3,4-dihydrochromene
• CAS: 1333118-59-4
• 化学式: C₁₈H₂₄O₃
• 分子量: 288.387
• InChiKey: GFCOXJBXEZTAJR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2-(prop-2-ynyloxymethyl)-2H-1-benzopyran 在 copper(ll) sulfate pentahydrate 、 三氟二甲基硫醚络合物 、 chloroamine-T 、 铜 作用下， 以 二氯甲烷 、 水 、 叔丁醇 为溶剂， 反应 2.0h， 生成 2-{[(3-(phenyl)isoxazol-5-yl)methoxy]methyl}-2,5,7,8-tetramethyl-2H-1-benzopyran-6-ol
  参考文献：
  名称：

  Isoxazole substituted chromans against oxidative stress-induced neuronal damage

  摘要：

  We have previously reported that catechol-bearing regioisomers of 5-isoxazolyl-6-hydroxy-chroman display higher in vitro neuroprotective activity, compared to hybrids with other nitrogen heterocycles, but their activity is hampered by cytotoxicity at higher concentrations. In an effort to discover non-cytotoxic isoxazole substituted chromans of high neuroprotective activity, 20 new 3- and 5-substituted (chroman-5-yl)-isoxazoles and (chroman-2-yl)-isoxazoles were synthesized using the copper(I)-catalysed cycloaddition reaction between in situ generated nitrile oxides and terminal acetylenes. An additional aim was to further explore the effect of the isoxazole ring substituents on the neuroprotective activity. The activity of these compounds against oxidative stress-induced death (oxytosis) of neuronal HT22 cells was evaluated and interesting SARs for this group of analogues were derived. The vast majority of new chroman analogues displayed high in vitro neuroprotective activity displaying EC(50) values below 1 mu M and lacked cytotoxicity. The position of substituents on the isoxazole ring influences the activity of the regioisomers, with the 3-aryl-5-(chroman-5-yl)-isoxazoles, 17 and 18 and bis-chroman 20 displaying higher neuroprotective activity (EC(50) similar to 0.3 mu M) compared to other (chroman-5-yl) and (chroman-2-yl)-isoxazoles. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.06.074
• 作为产物：
  描述：

  3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid methyl ester 在 lithium aluminium tetrahydride 、 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 生成 3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2-(prop-2-ynyloxymethyl)-2H-1-benzopyran
  参考文献：
  名称：

  [EN] BIOISPIRED PROTEASOME ACTIVATORS WITH ANTIAGEING ACTIVITY
  [FR] ACTIVATEURS BIO-INSPIRÉS DES PROTÉASOMES AYANT UNE ACTIVITÉ ANTI-ÂGE

  摘要：

  本发明涉及新型生物启发的混合化合物，其化学式为I，作为蛋白酶体激活剂并具有抗衰老活性，以及其合成方法。这些混合化合物将羟基酪醇和天然抗氧化维生素E或其生物同系物的结构特征结合在一个分子支架中。化合物I的结构包括结构蛋白酶体激活剂（通过立体化学相互作用激活），可用于生产抗衰老产品，如化妆品制剂。此外，它们可以在蛋白酶体被下调的情况和疾病中使用，以及用作蛋白酶体激活控制化合物。

  公开号：

  WO2019171088A1

文献信息

• Synergistic effect of dual-frequency ultrasound irradiation in the one-pot synthesis of 3,5-disubstituted isoxazoles
  作者：Maria Koufaki、Theano Fotopoulou、Georgios A. Heropoulos

  DOI：10.1016/j.ultsonch.2013.05.012

  日期：2014.1

  Herein is reported a one-pot three-step process for the regioselective synthesis of 3,5-disubstituted isoxazoles based on copper(I)-catalyzed cycloaddition reaction between in situ generated nitrile oxides (from the corresponding aldehydes) and alkynes, using ultrasound irradiation, avoiding toxic reagents and solvents and isolation/purification of intermediates. The combined use of 40 kHz ultrasonic

  本文报道了一种基于一锅法的三步法，该方法是利用铜（I）在原位生成的腈氧化物（来自相应的醛）与炔烃之间进行铜（I）催化的环加成反应，通过超声辐射进行区域选择性合成3,5-二取代的异恶唑，避免使用有毒的试剂和溶剂以及中间体的分离/纯化。在铜车削的情况下，结合使用40 kHz超声波浴和20 kHz探头，可将反应时间缩短至1h，并且仅进行一个最终纯化步骤即可提高产率，这清楚表明存在双频协同效应。另外，在无金属的条件下，1，3-偶极环加成是区域选择性的，给出低至中等的产率。
• Microwave-assisted synthesis of 3,5-disubstituted isoxazoles and evaluation of their anti-ageing activity
  作者：Maria Koufaki、Theano Fotopoulou、Marianna Kapetanou、Georgios A. Heropoulos、Efstathios S. Gonos、Niki Chondrogianni

  DOI：10.1016/j.ejmech.2014.06.046

  日期：2014.8

  One-pot uncatalysed microwave-assisted 1,3-dipolar cycloaddition reactions between in situ generated nitrile oxides and alkynes bearing protected antioxidant substituents, were regioselectively afforded 3,5-disubstituted isoxazoles. The yields were moderate, based on the starting aldehydes, while the reaction times were in general shorter than those reported in the literature. The cytoprotective and anti-ageing effect of the final deprotected compounds was evaluated in vitro, on cellular survival following oxidative challenge and in vivo, on organismal longevity using the nematode Caenorhabditis elegans. The activity of the isoxazole analogues depends on the nature and the number of the antioxidant substituents. Analogue 17 bearing a phenolic group and a 6-OH-chroman group is a promising anti-ageing agent, since it increased survival of human primary fibroblasts following treatment with H2O2 and extended C. elegans lifespan.