phosphoric acid bis-(4-bromo-benzyl ester) | 409324-16-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: phosphoric acid bis-(4-bromo-benzyl ester)
• 英文别名: Phosphorsaeure-bis-(4-brom-benzylester)；Bis-(4-brom-benzyl)-hydrogenphosphat；Di-p-brombenzyl-hydrogenphosphat；Di-p-brombenzyl-phosphat；Bis[(4-bromophenyl)methyl] hydrogen phosphate
• CAS: 409324-16-9
• 化学式: C₁₄H₁₃Br₂O₄P
• 分子量: 436.037
• InChiKey: MXOMTIHCGKLVEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  phosphoric acid bis-(4-bromo-benzyl ester) 在 乙二醇乙醚 、 lithium chloride 作用下， 生成 phosphoric acid mono-(4-bromo-benzyl ester)
  参考文献：
  名称：

  Synthesis of Organic Phosphorus Compounds. II. Exhaustive Debenzylation Reactions

  摘要：

  DOI：

  10.1021/ja01618a029
• 作为产物：
  描述：

  bis[(4-bromophenyl)methoxy]-oxophosphanium 在 四氯化碳 、 磺酰氯 作用下， 生成 phosphoric acid bis-(4-bromo-benzyl ester)
  参考文献：
  名称：

  Synthesis of Organic Phosphorus Compounds. II. Exhaustive Debenzylation Reactions

  摘要：

  DOI：

  10.1021/ja01618a029

文献信息

• Mood Disorders During Pregnancy and Lactation: Defining Issues of Exposure and Treatment
  作者：Zachary N. Stowe、Kelley Calhoun、Clayton Ramsey、Noha Sadek、Jeffrey Newport

  DOI：10.1017/s1092852900007914

  日期：2001.2

  Epidemiologic studies have consistently demonstrated a greater incidence of depressive disorders and anxiety among women. Many women experience these conditions during the reproductive years. The dramatic expanse of literature focusing on the use of medications often has failed to pay homage to the potential impact of the disorders. When considering the extant human and laboratory data on mental illness and stress during pregnancy and the postpartum period, it is evident that some degree of exposure (be it treatment or illness) always occurs. The primary goal of the risk-benefit assessment for the treatment of mental illness during these periods is to assist patients and their families in choosing the path of potential exposure that possesses the least risk for them. Once this decision is made, the goal is to limit the number of exposures for the fetus/neonate.

  摘要流行病学研究一致表明，女性抑郁症和焦虑症的发病率较高。许多女性在生育期都会出现这些症状。大量文献关注的是药物的使用，却往往忽视了这些疾病的潜在影响。从人类和实验室关于孕期和产后精神疾病和压力的现有数据来看，显然总会有一定程度的接触（无论是治疗还是疾病）。对这些时期的精神疾病治疗进行风险效益评估的主要目的，是帮助患者及其家属选择对他们来说风险最小的潜在暴露途径。一旦做出这一决定，目标就是限制胎儿/新生儿接触的次数。
• Process for the preparation of sodium fosphenytoin
  申请人：Kirsch Volker

  公开号：US20050272706A1

  公开（公告）日：2005-12-08

  Phosphoric acid diester 2,5-dioxo-4,4-diphenylimidazolidin-1-ylmethyl esters, both of whose ester groups can be selectively cleaved, are obtained by converting 3-(hydroxymethyl)-5,5-diphenylimidazolidine-2,4-dione to an alkylsulfonate or arylsulfonate and reacting this with a phosphoric acid diester whose ester groups can be selectively cleaved from the reaction product. The two ester groups can be selectively cleaved from the phosphoric acid diesters obtained and the resulting product can be converted to 5,5-diphenyl-3-[(phosphonooxy)methyl]imidazolidine-2,4-dione disodium salt. The latter is an anticonvulsive, antiepileptic and antiarrhythmic known under the abbreviated name of sodium fosphenytoin.

  磷酸二酯2,5-二氧代-4,4-二苯基咪唑烷-1-甲酯，其两个酯基可选择性地被裂解，通过将3-(羟甲基)-5,5-二苯基咪唑烷-2,4-二酮转化为烷磺酸酯或芳基磺酸酯，并将其与一个磷酸二酯反应而获得。从所得的磷酸二酯中可以选择性地裂解两个酯基，得到的产物可以转化为5,5-二苯基-3-[(磷酸酯氧)甲基]咪唑烷-2,4-二酮二钠盐。后者是一种抗抽搐、抗癫痫和抗心律失常药物，简称为磷酸美多嗪钠。
• Dealkylation and Debenzylation of Triesters of Phosphoric Acid. Phosphorylation of Hydroxy and Amino Compounds
  作者：Leonidas Zervas、Irene Dilaris

  DOI：10.1021/ja01625a045

  日期：1955.10
• Cosmatos,A. et al., Chemische Berichte, 1961, vol. 94, p. 2644 - 2655
  作者：Cosmatos,A. et al.

  DOI：——

  日期：——
• Baddiley et al., Journal of the Chemical Society, 1949, p. 815,819
  作者：Baddiley et al.

  DOI：——

  日期：——