N-(2-dimethylaminoethyl)-2-pyrrolidone | 7383-80-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N-(2-dimethylaminoethyl)-2-pyrrolidone
• 英文别名: 1-(2-dimethylamino-ethyl)-pyrrolidin-2-one；1-(2-Dimethylamino-aethyl)-pyrrolidin-2-on；2-Pyrrolidinone, 1-[2-(dimethylamino)ethyl]-；1-[2-(dimethylamino)ethyl]pyrrolidin-2-one
• CAS: 7383-80-4
• 化学式: C₈H₁₆N₂O
• 分子量: 156.228
• InChiKey: XAANDCRXSFMGQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(2-dimethylaminoethyl)-2-pyrrolidone 在 盐酸 作用下， 反应 16.0h， 生成 γ-(N-dimethylaminoethylamino)butyric acid dihydrochloride
  参考文献：
  名称：

  Ozdowska, Zofia, Polish Journal of Chemistry, 1983, vol. 57, # 1-3, p. 259 - 263

  摘要：

  DOI：
• 作为产物：
  描述：

  2-吡咯烷酮 在 氢化钾 、 xylene 作用下， 生成 N-(2-dimethylaminoethyl)-2-pyrrolidone
  参考文献：
  名称：

  Ohki, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1950, vol. 70, p. 92,98

  摘要：

  DOI：

文献信息

• Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
  申请人：caprotec bioanalytics GmbH

  公开号：EP2053406A2

  公开（公告）日：2009-04-29

  Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also provided.

  本研究提供了用于分析生物大分子的捕获化合物及其集合以及使用这些化合物的方法。特别是提供了用于分析复杂蛋白质混合物（如蛋白质组）的化合物集、化合物和方法。这些化合物是多功能试剂，可用于分离复杂蛋白质混合物。还提供了用于执行这些方法的自动化系统。
• Contaminant removal process
  申请人：Taminco BVBA

  公开号：US11383197B2

  公开（公告）日：2022-07-12

  Disclosed is a process comprising: step a) contacting a feed stream comprising a contaminant with an absorbent stream in a counter-current flow to produce a contaminant depleted product stream depleted in the molar quantity of the contaminant relative to the molar quantity of said contaminant in the feed stream, and a contaminant enriched absorbent stream enriched in the molar quantity of the contaminant relative to the molar quantity of said contaminant in the absorbent stream; and step b) treating the contaminant enriched absorbent stream to form a gaseous stream comprising said contaminant and a regenerated absorbent stream lean in the molar quantity of said contaminant relative to the molar quantity of said contaminant in the contaminant enriched absorbent stream; herein said absorbent stream comprises at least 15 wt. % of at least one compound (A) of general formula (I) or a mixture (M) comprising at least one compound (B) of general formula (II) and at least one compound (C) of general formula (III).

  所披露的工艺包括 步骤 a）将包含污染物的进料流与吸收剂流逆流接触，以产生相对于进料流中所述污染物摩尔量而言污染物摩尔量贫化的贫化产物流，以及相对于吸收剂流中所述污染物摩尔量而言污染物摩尔量富化的富化吸收剂流；以及 步骤 b）处理富含污染物的吸收液流，以形成包含所述污染物的气态液流和相对于富含污染物的吸收液流中所述污染物摩尔量而言富含所述污染物摩尔量的再生吸收液流；在此，所述吸收液流包含至少 15 重量％的至少一种通式（I）的化合物（A）或包含至少一种通式（II）的化合物（B）和至少一种通式（III）的化合物（C）的混合物（M）。
• Synthesis, conformational characteristics and anti-influenza virus A activity of some 2-adamantylsubstituted azacycles
  作者：Despina Setaki、Dimitris Tataridis、George Stamatiou、Antonios Kolocouris、George B. Foscolos、George Fytas、Nicolas Kolocouris、Elizaveta Padalko、Johan Neyts、Erik De Clercq

  DOI：10.1016/j.bioorg.2006.05.004

  日期：2006.10

  The broad-spectrum antiviral activity of 2-(2-adamantyl)piperidines 11, 13a,b, and 15, 3-(2-adamantyl)pyrrolidines 27, 21a-g and 2-(2-adamantylmethyl)piperidines 30, 32a-c, and 35a-d was examined. Several compounds in the new series were potent against influenza A H3N2 virus. When 1-aminoethyl pharmacophore group of 2-rimantadine 4 (2-isomer of rimantadine) is included into a saturated nitrogen heterocycle, see compound 11, potency was retained. The diamine derivatives 21e-g and particularly 35a-c possessing three pharmocophoric groups, that is, the adamantyl and the two amine groups, exhibited high potency. The new compounds did not afford specific activity at non-toxic concentrations against any of the other viruses tested. According to NMR spectroscopy and molecular mechanics calculations it is striking that the parent structures 11 and 27 adopt a fixed trans conformation around C2-C2' bond. In the parent amines, which proved to be active compounds, the distance between nitrogen and adamantyl pharmacophoric groups was different; N-C2' distance is 3.7, 3.8 angstrom for 27, 30 and 2.5 angstrom for 11 suggesting that M2 receptor site can accommodate different in size and orientation lipophilic cages. (c) 2006 Elsevier Inc. All rights reserved.
• Novel 3-(2-Adamantyl)pyrrolidines with potent activity against influenza A virus—identification of aminoadamantane derivatives bearing two pharmacophoric amine groups
  作者：George Stamatiou、Antonios Kolocouris、Nicolas Kolocouris、George Fytas、George B Foscolos、Johan Neyts、Erik De Clercq

  DOI：10.1016/s0960-894x(01)00388-2

  日期：2001.8

  The 3-(2-adamantyl)pyrrolidines 8a-g. 14 were synthesized and evaluated for activity against influenza A virus. The parent N-H compound 14 was several times more active than amantadine against H2N2 and H3N2 influenza A virus. The combined use of NMR spectroscopy and computational chemistry showed that the conformation around the pyrrolidine-adamantyl carbon-carbon bond is trans and the pyrrolidine heterocycle has an envelope conformation with C-2 out of the plane of the other ring atoms. N-Dialkylaminoethyl substitution of compound 14 resulted in the potent diamine analogues 8e,f,g. Interestingly, their lactam amine precursors were also active. Compounds 8e,f,g are the first adamantane derivatives, bearing two amine groups, reported to be active against influenza A virus. (C) 2001 Elsevier Science Ltd. All rights reserved.
• OZDOWSKA, Z., POL. J. CHEM., 1983, 57, N 1-3, 259-263
  作者：OZDOWSKA, Z.

  DOI：——

  日期：——