甲基膦酸单乙酯 | 34637-92-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 中文名称: 甲基膦酸单乙酯
• 英文名称: methanephosphonic acid monoethylester
• 英文别名: Methyl ethylphosphinate；Ethylphosphonosaeuremethylester；Methoxy-ethyl-phosphorsaeure；Monomethyl ethylphosphonate；ethyl(methoxy)phosphinic acid
• CAS: 34637-92-8
• 化学式: C₃H₉O₃P
• 分子量: 124.076
• InChiKey: SMNZHEHSKZSQLM-UHFFFAOYSA-N

物化性质

• 沸点：
  80-90 °C(Press: 16 Torr)
• 密度：
  1.169±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  甲醇 、 甲基膦酸单乙酯 在 氯化亚砜 作用下， 反应 2.0h， 生成 乙基膦酸二甲酯
  参考文献：
  名称：

  利用 P-烷基 2,3-氧杂磷杂双环 [2.2.2] 辛烯 3-氧化物前体对亲核试剂进行片段化相关的膦酰化

  摘要：

  新的 P-烷基 2,3-氧杂磷杂双环-[2.2.2] 辛烯 3-氧化物是通过相应的 7-磷酰冰片烯 7-氧化物的 Bayer-Villiger 氧化合成的，并用作反应性烷基偏膦酸酯的前体，可用于醇的膦酰化. 这是第一个通过 O 插入形成的两种区域异构体的反应性不同的情况，并且在微波辅助条件下实现了导致膦酸酯的断裂相关的膦酰化。

  DOI：

  10.1002/hc.21304
• 作为产物：
  描述：

  乙基膦酸二甲酯 在 sodium hydroxide 作用下， 生成 甲基膦酸单乙酯
  参考文献：
  名称：

  Sosnovsky,S.; Konieczny,M., Phosphorus and the Related Group V Elements, 1974, vol. 4, p. 255 - 264

  摘要：

  DOI：

文献信息

• Resolution of Chiral Phosphate, Phosphonate, and Phosphinate Esters by an Enantioselective Enzyme Library
  作者：Charity Nowlan、Yingchun Li、Johannes C. Hermann、Timothy Evans、Joseph Carpenter、Eman Ghanem、Brian K. Shoichet、Frank M. Raushel

  DOI：10.1021/ja0658618

  日期：2006.12.1

  phosphotriesterase and 15 mutant enzymes. For each substrate, the leaving group was 4-hydroxyacetophenone while the other two groups attached to the phosphorus core consisted of an asymmetric mixture of methyl, methoxy, ethyl, ethoxy, isopropoxy, phenyl, phenoxy, cyclohexyl, and cyclohexoxy substituents. For the wild-type enzyme, the relative rates of hydrolysis for the two enantiomers ranged from 3 to 5.4 x 10(5)

  一系列 16 个手性磷酸酯、膦酸酯和次膦酸酯的对映体对用于确定细菌磷酸三酯酶和 15 种突变酶内固有的立体选择性歧视的广度。对于每种底物，离去基团是 4-羟基苯乙酮，而与磷核相连的其他两个基团由甲基、甲氧基、乙基、乙氧基、异丙氧基、苯基、苯氧基、环己基和环己氧基取代基的不对称混合物组成。对于野生型酶，两种对映异构体的相对水解速率范围为 3 到 5.4 x 10(5)。使用活性位点内的位点特异性突变的各种组合来创建修饰酶，其对映选择性特性发生改变。对于单点突变酶 G60A，立体选择性相对于野生型酶提高了 1-3 个数量级。获得了额外的突变体，其中对于本研究测试的 16 对对映异构体中的 13 对，立体选择性与野生型酶相反。最引人注目的例子是 4-乙酰苯基甲基苯基磷酸酯的水解。G60A 突变体优先水解 SP 对映异构体的因子为 3.7 x 10(5)。I106G/F132G/H257Y 突变体以
• Sauvigny, A.; Faerber, J. E.; Rihm, A., Zeitschrift fur Anorganische und Allgemeine Chemie
  作者：Sauvigny, A.、Faerber, J. E.、Rihm, A.、Thurn, H.、Schmidt, A.

  DOI：——

  日期：——
• Synthesis of 1,2,3,4,6-penta-O-acetyl-5-deoxy-5-C-[(RS)-ethylphosphinyl]-.alpha.- and .beta.-D-glucopyranoses and their structural analysis by 400-MHz proton nuclear magnetic resonance
  作者：Hiroshi Yamamoto、Keizo Yamamoto、Saburo Inokawa、Mitsuji Yamashita、Margaret Ann Armour、Tom T. Nakashima

  DOI：10.1021/jo00152a006

  日期：1983.2
• ZnFe2O4/ZrO2/NaX zeolite nanocomposite catalyst: elaboration and its application for the removal of dimethyl 4-nitrophenyl phosphate (DMNP) chemical nerve agent simulant from water solution
  作者：Meysam Sadeghi、Pourya Zarshenas

  DOI：10.1007/s11164-022-04940-1

  日期：——

  In this research, the ZnFe2O4/ZrO2/NaX zeolite was synthesized via firstly fabricating the NaX zeolite by the hydrothermal method, followed with supporting the ZnFe2O4/ZrO2 nanoparticles through the ultrasound-assisted hydrothermal route. The as-prepared ZnFe2O4/ZrO2/NaX nanocomposite was well analyzed applying the FESEM, TEM, AFM, EDX, XRD, FTIR, BET, VSM, and XPS. Then, the ZnFe2O4/ZrO2/NaX was applied for the removal of the dimethyl 4-nitrophenyl phosphate (DMNP) as a toxic chemical nerve agent simulant from water solution and monitored using the 31PNMR and UV–Vis analyses. The impacts of some factors, including reaction time, initial concentration of the DMNP and catalyst amount on the removal efficiency of this agent simulant, were evaluated, as well. The 31PNMR and UV–Vis outcomes illustrated that the DMNP molecule was entirely removed in the presence of the ZnFe2O4/ZrO2/NaX catalyst under the optimized experimental conditions. The analytical parameters, involving reaction time of 11 min, catalyst amount of 4 mg and initial DMNP concentration of 25 mg/mL, were considered for the removal process. The process kinetic was appraised applying the first-order model. The values of the reaction apparent rate constant (kapp) and half-life (t1/2) of the ZnFe2O4/ZrO2/NaX-DMNP system were reached to be 0.1639 min−1 and 4.22 min, respectively. The adsorption isotherm models of the Langmuir, Freundlich and Halsey were also studied. The adsorption isotherm outcome is fitted via the Langmuir model. Additionally, the investigation of the thermodynamic factors like $$\Delta$$ G0, $$\Delta$$ H0 and $$\Delta$$ S0, revealed that the DMNP adsorption reaction was spontaneous and displays a physicochemical adsorption features and exothermic nature of the adsorption. Please confirm the corresponding author of the article and the first/last name of the authors are correctly identified.The corresponding author of the article and the first/last name of the authors are correctly identified. Magnetic recyclable ZnFe2O4/ZrO2/NaX nanocomposite was successfully elaborated and utilized as a novel catalyst for the effective removal of the dimethyl 4-nitrophenyl phosphate (DMNP) from water solution.