4-tricyclo[4.3.1.0(3,8)]decanamime | 1149588-60-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-tricyclo[4.3.1.0(3,8)]decanamime
• 英文别名: 4-aminoprotoadamantane；4-proto-adamantanamine；tricyclo[4.3.1.03,8]decan-4-amine
• CAS: 1149588-60-2
• 化学式: C₁₀H₁₇N
• mdl: MFCD04636907
• 分子量: 151.252
• InChiKey: QHBXVCQWOXVNJK-UHFFFAOYSA-N

物化性质

• 沸点：
  225.9±8.0 °C(Predicted)
• 密度：
  1.028±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-tricyclo[4.3.1.0(3,8)]decanamime 在 盐酸 作用下， 以 乙醇 为溶剂， 生成 4-tricyclo[4.3.1.0(3,8)]decanamime hydrochloride
  参考文献：
  名称：

  Design and synthesis of bioactive adamantanaminoalcohols and adamantanamines

  摘要：

  Adamantanamines 16, 18, 21, 24, 27, 28, 30, 32, 35, 36, 37, 40, 46 and 48 were synthesized and tested for anti-influenza A virus and trypanocidal activity. The stereoelectronic requirements for optimal antiviral and trypanocidal potency were investigated. The effect of introducing a hydroxyl group close to the amino group on this class of compounds was examined for the first time. Aminoalcohol 24 proved to be the most active of the compounds tested against influenza A virus, being 6-fold more active than amantadine, equipotent to rimantadine and 26-fold more potent than ribavirin. Aminoalcohols 36 and 37 were found to have considerable activity against bloodstream forms of the African trypanosome, Trypanosoma brucei, being almost 10 times more potent than rimantadine. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.08.009
• 作为产物：
  描述：

  N-(4-tricyclo[4.3.1.03,8]decanylidene)hydroxylamine 在 氢气 作用下， 以 乙醇 为溶剂， 90.0 ℃ 、379.22 kPa 条件下， 反应 8.0h， 以0.63 g的产率得到4-tricyclo[4.3.1.0(3,8)]decanamime
  参考文献：
  名称：

  Design and synthesis of bioactive adamantanaminoalcohols and adamantanamines

  摘要：

  Adamantanamines 16, 18, 21, 24, 27, 28, 30, 32, 35, 36, 37, 40, 46 and 48 were synthesized and tested for anti-influenza A virus and trypanocidal activity. The stereoelectronic requirements for optimal antiviral and trypanocidal potency were investigated. The effect of introducing a hydroxyl group close to the amino group on this class of compounds was examined for the first time. Aminoalcohol 24 proved to be the most active of the compounds tested against influenza A virus, being 6-fold more active than amantadine, equipotent to rimantadine and 26-fold more potent than ribavirin. Aminoalcohols 36 and 37 were found to have considerable activity against bloodstream forms of the African trypanosome, Trypanosoma brucei, being almost 10 times more potent than rimantadine. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.08.009

文献信息

• [EN] PYRIDAZINONE DERIVATIVES AND USE THEREOF AS P2X7 RECEPTOR INHIBITORS<br/>[FR] DÉRIVÉS DE PYRIDAZINONE ET LEUR UTILISATION COMME INHIBITEURS DU RÉCEPTEUR P2X7
  申请人：NISSAN CHEMICAL IND LTD

  公开号：WO2009057827A1

  公开（公告）日：2009-05-07

  Novel pyridazinone compounds of formula (I), which inhibit the purinergic P2X7 receptor and are useful for prevention, therapy and improvement of inflammatory and immunological diseases.

  翻译结果为：新型的哒嗪酮化合物，其化学公式为(I)，能够抑制嘌呤能P2X7受体，并对预防、治疗和改善炎症性和免疫性疾病有益。
• [EN] ADAMANTANE ANALOGS<br/>[FR] ANALOGUES D'ADAMANTANE
  申请人：UNIV PENNSYLVANIA

  公开号：WO2011022191A1

  公开（公告）日：2011-02-24

  Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.

  提供了一些化合物，这些化合物能够通过与M2跨膜蛋白的相互作用来调节流感A病毒的活性。还提供了治疗流感A受影响疾病状态或感染的方法，包括给予包含已被确认能够与M2蛋白相互作用的一个或多个化合物的组合物。
• ADAMANTANE ANALOGS
  申请人：DeGrado William F.

  公开号：US20120270917A1

  公开（公告）日：2012-10-25

  Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.

  提供了能够通过与M2跨膜蛋白相互作用来调节甲型流感病毒活性的化合物。还提供了治疗甲型流感受影响疾病状态或感染的方法，包括给予一个被鉴定为能够与M2蛋白相互作用的一个或多个化合物组成的组合物。
• PYRIDAZINONE COMPOUNDS AND P2X7 RECEPTOR INHIBITORS
  申请人：Shigeta Yukihiro

  公开号：US20100286390A1

  公开（公告）日：2010-11-11

  Novel pyridazinone compounds of formula (I), which inhibit the purinergic P2X7 receptor and are useful for prevention, therapy and improvement of inflammatory and immunological diseases.

  化合物(I)是一种新型的吡啶并嗪酮化合物，可以抑制嘌呤能P2X7受体，因此可用于预防、治疗和改善炎症和免疫性疾病。
• Annulated carbamates are precursors for the ring contraction of the adamantane framework
  作者：Radim Hrdina、Oksana M. Holovko-Kamoshenkova、Ivana Císařová、Filip Koucký、Oldřich Machalický

  DOI：10.1039/d2ra06402b

  日期：——

  We report a protocol for the one-pot two-step synthesis of noradamantane methylene amines.

  我们报告了一种一步法两步合成正金刚烷亚甲基胺的方案。