1-[4-(1-Benzofuran-2-yl)phenyl]imidazole | 1373220-83-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: 1-[4-(1-Benzofuran-2-yl)phenyl]imidazole
• CAS: 1373220-83-7
• 化学式: C₁₇H₁₂N₂O
• 分子量: 260.295
• InChiKey: BSNSZOIRZDHVDG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  31
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-[4-(1-Benzofuran-2-yl)phenyl]imidazole 、 2-溴溴苄 以 甲苯 为溶剂， 以86%的产率得到1-[4-(1-Benzofuran-2-yl)phenyl]-3-[(2-bromophenyl)methyl]imidazol-3-ium;bromide
  参考文献：
  名称：

  Design, synthesis and cytotoxic activities of novel hybrid compounds between 2-phenylbenzofuran and imidazole

  摘要：

  A series of novel hybrid compounds between 2-phenylbenzofuran and imidazole have been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that substitution of the imidazolyl-3-position with a naphthylacyl or bromophenacyl group, were vital for modulating cytotoxic activity. In particular, hybrid compound 15 was found to be the most potent compound against 4 strains human tumor cell lines and more active than cisplatin (DDP), and exhibited cytotoxic activity selectively against liver carcinoma (SMMC-7721). (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.02.094
• 作为产物：
  描述：

  2-(4-nitrophenyl)-1-benzofurane 在 氨 、 tin(ll) chloride 作用下， 以 甲醇 、 乙醇 、 水 为溶剂， 反应 20.0h， 生成 1-[4-(1-Benzofuran-2-yl)phenyl]imidazole
  参考文献：
  名称：

  Design, synthesis and cytotoxic activities of novel hybrid compounds between 2-phenylbenzofuran and imidazole

  摘要：

  A series of novel hybrid compounds between 2-phenylbenzofuran and imidazole have been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that substitution of the imidazolyl-3-position with a naphthylacyl or bromophenacyl group, were vital for modulating cytotoxic activity. In particular, hybrid compound 15 was found to be the most potent compound against 4 strains human tumor cell lines and more active than cisplatin (DDP), and exhibited cytotoxic activity selectively against liver carcinoma (SMMC-7721). (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.02.094

文献信息

• Design, synthesis and cytotoxic activities of novel hybrid compounds between 2-phenylbenzofuran and imidazole
  作者：Xiao-Dong Yang、Wei-Chao Wan、Xiao-Yan Deng、Yan Li、Li-Juan Yang、Liang Li、Hong-Bin Zhang

  DOI：10.1016/j.bmcl.2012.02.094

  日期：2012.4

  A series of novel hybrid compounds between 2-phenylbenzofuran and imidazole have been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that substitution of the imidazolyl-3-position with a naphthylacyl or bromophenacyl group, were vital for modulating cytotoxic activity. In particular, hybrid compound 15 was found to be the most potent compound against 4 strains human tumor cell lines and more active than cisplatin (DDP), and exhibited cytotoxic activity selectively against liver carcinoma (SMMC-7721). (C) 2012 Elsevier Ltd. All rights reserved.