3-ethyl-5,5-dimethyl-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid | 910635-45-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 3-ethyl-5,5-dimethyl-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid
• 英文别名: 3-ethyl-5,5-dimethyl-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid；3-ethyl-5,5-dimethyl-6,7-dihydro-4H-2-benzothiophene-1-carboxylic acid
• CAS: 910635-45-9
• 化学式: C₁₃H₁₈O₂S
• 分子量: 238.351
• InChiKey: ZKDQRNBEGSPNQJ-UHFFFAOYSA-N

物化性质

• 沸点：
  360.0±42.0 °C(Predicted)
• 密度：
  1.137±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  65.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-ethyl-5,5-dimethyl-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid 在 盐酸 、 palladium 10% on activated carbon 、 氢气 作用下， 以 四氢呋喃 、 乙醚 、 乙醇 、 异丙醇 为溶剂， 20.0~26.0 ℃ 、150.0 kPa 条件下， 反应 6.92h， 生成 1-(3-ethyl-5,5-dimethyl-4,5,6,7-tetrahydro-benzo[c]thiophen-1-yl)-3-(4-hydroxy-3,5-dimethyl-phenyl)-propan-1-one
  参考文献：
  名称：

  Novel S1P₁ Receptor Agonists - Part 2: From Bicyclo[3.1.0]hexane-Fused Thiophenes to Isobutyl Substituted Thiophenes

  摘要：

  Previously, we reported on the discovery of a novel series of bicyclo[3.1.0]hexane fused thiophene derivatives that serve as potent and selective S1P(1), receptor agonists. Here, we discuss our efforts to simplify the bicyclohexane fused thiophene head. In a first step the bicyclohexane moiety could be replaced by a simpler, less rigid cyclohexane ring without compromising the SIP receptor affinity profile of these novel compounds. In a second step, the thiophene head was simplified even further by replacing the cyclohexane ring with an isobutyl group attached either to position 4 or position S of the thiophene. These structurally much simpler headgroups again furnished potent and selective S1P(1) agonists (e.g., 87), which efficiently and dose dependently reduced the number of circulating lymphocytes upon oral administration to male Wistar rats. For several compounds discussed in this report lymphatic transport is an important route of absorption that may offer opportunities for a tissue targeted approach with minimal plasma exposure.

  DOI：

  10.1021/jm401456d
• 作为产物：
  描述：

  4,4-二甲基环己酮 在 草酰氯 、 乙醇 、 potassium tert-butylate 、 水 、 叔丁基锂 、 sodium 、 lithium hydroxide 作用下， 以 四氢呋喃 、 乙醇 、 氯仿 、 叔丁醇 、 正戊烷 为溶剂， 反应 6.75h， 生成 3-ethyl-5,5-dimethyl-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid
  参考文献：
  名称：

  Novel S1P₁ Receptor Agonists - Part 2: From Bicyclo[3.1.0]hexane-Fused Thiophenes to Isobutyl Substituted Thiophenes

  摘要：

  Previously, we reported on the discovery of a novel series of bicyclo[3.1.0]hexane fused thiophene derivatives that serve as potent and selective S1P(1), receptor agonists. Here, we discuss our efforts to simplify the bicyclohexane fused thiophene head. In a first step the bicyclohexane moiety could be replaced by a simpler, less rigid cyclohexane ring without compromising the SIP receptor affinity profile of these novel compounds. In a second step, the thiophene head was simplified even further by replacing the cyclohexane ring with an isobutyl group attached either to position 4 or position S of the thiophene. These structurally much simpler headgroups again furnished potent and selective S1P(1) agonists (e.g., 87), which efficiently and dose dependently reduced the number of circulating lymphocytes upon oral administration to male Wistar rats. For several compounds discussed in this report lymphatic transport is an important route of absorption that may offer opportunities for a tissue targeted approach with minimal plasma exposure.

  DOI：

  10.1021/jm401456d

文献信息

• Hydrogenated Benzo (C) Thiophene Derivatives as Immunomodulators
  申请人：Bolli Martin

  公开号：US20080176926A1

  公开（公告）日：2008-07-24

  The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.

  该发明涉及新型噻吩衍生物，其制备以及其作为药用活性化合物的用途。这些化合物特别作为免疫抑制剂。
• Novel Pyridine Derivatives
  申请人：Bolli Martin

  公开号：US20090005421A1

  公开（公告）日：2009-01-01

  The invention relates to novel pyridine derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.

  这项发明涉及新型吡啶衍生物，它们的制备以及它们作为药用活性化合物的用途。这些化合物特别作为免疫抑制剂。
• Novel Thiophene Derivatives
  申请人：Bolli Martin

  公开号：US20080300294A1

  公开（公告）日：2008-12-04

  The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.

  本发明涉及新型噻吩衍生物，其制备和用作药物活性化合物。所述化合物特别作为免疫抑制剂。
• HYDROGENATED BENZO (C) THIOPHENE DERIVATIVES AS IMMUNOMODULATORS
  申请人：Bolli Martin

  公开号：US20100204198A1

  公开（公告）日：2010-08-12

  The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.

  该发明涉及新型噻吩衍生物，其制备及其作为药物活性化合物的用途。所述化合物特别作为免疫抑制剂。
• Thiophene derivatives
  申请人：Actelion Pharmaceuticals Ltd.

  公开号：US07981924B2

  公开（公告）日：2011-07-19

  The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.

  本发明涉及新型噻吩衍生物，其制备方法以及作为药物活性化合物的用途。所述化合物特别作为免疫抑制剂。