N,N,8-trimethylnaphthalen-1-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N,N,8-trimethylnaphthalen-1-amine
• 化学式: C₁₃H₁₅N
• 分子量: 185.269
• InChiKey: DRRZUSOYDGPVIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N,N,8-trimethylnaphthalen-1-amine 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 四氢呋喃 为溶剂， 以84 %的产率得到2,4-dibromo-N,N,8-trimethylnaphthalen-1-amine
  参考文献：
  名称：

  邻溴-N,N-二甲基苯胺及相关萘中卤素-锂交换的“支撑效应”

  摘要：

  介绍了“支撑效应”的表现——第三基团的存在导致两个取代基之间的间接相互作用——及其对溴-锂交换的容易性和选择性以及所形成的芳基锂的反应性的影响。在带有两个溴的萘底物中，证明了对反应区域选择性的影响。

  DOI：

  10.1002/chem.202303956
• 作为产物：
  描述：

  8-(dimethylamino)-N,N,N-trimethylnaphthalen-1-aminium trifluoromethanesulfonate 、 三甲基铝 在 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) 作用下， 以 1,4-二氧六环 为溶剂， 反应 24.0h， 以40%的产率得到N,N,8-trimethylnaphthalen-1-amine
  参考文献：
  名称：

  镍催化的有机铝试剂与芳基或2-萘基季铵盐三氟甲磺酸酯的交叉偶联

  摘要：

  芳基三甲基铵三氟甲磺酸酯与AlMe 3和含β-H的三烷基铝的交叉偶联是在二恶烷中，在（dppp）NiCl 2的催化下，在110°C下进行的，从而得到烷基化的芳烃。三氟甲磺酸2-萘基三甲基铵与三烷基铝的交叉偶联和三氟甲磺酸1-萘基三甲基铵与三芳基铝的交叉偶联也分别进行。

  DOI：

  10.1016/j.tet.2017.06.004

文献信息

• METHODS OF PREPARING INDAZOLE COMPOUNDS
  申请人：Ewanicki Leigh Brigitte

  公开号：US20070203196A1

  公开（公告）日：2007-08-30

  The present invention relates to methods for preparing indazole compounds of formula I, which are useful as modulators and/or inhibitors of protein kinases. The present invention also relates to intermediate compounds useful in the preparation of compounds of formula I.

  本发明涉及制备式I的吲唑化合物的方法，该化合物可用作蛋白激酶的调节剂和/或抑制剂。本发明还涉及在制备式I化合物中有用的中间体化合物。
• SPIROPIPERIDINES FOR USE AS TRYPTASE INHIBITORS
  申请人：Costanzo Michael J.

  公开号：US20120165327A1

  公开（公告）日：2012-06-28

  The present invention is directed to a compound of Formula (I): or a form thereof, wherein X 1 , X 2 , X 3 , X 4 , R 1 , R 2 and R 3 are as defined herein, useful as tryptase inhibitors.

  本发明涉及一个公式(I)的化合物或其形式，其中X1，X2，X3，X4，R1，R2和R3如本文所定义，可用作组胺酶抑制剂。
• Epothilone Compounds, Preparation Method and Use Thereof
  申请人：Tang Li

  公开号：US20120322838A1

  公开（公告）日：2012-12-20

  Epothilone compounds represented by formula (I), their preparation methods and their use for preparing medicines are disclosed. The epothilone compounds are prepared by bioconversion and chemosynthesis or chemical modifications using epothilones or their derivatives as starting materials. Said epothilone compounds can be sued to treat proliferative diseases.
• USE OF SUPPORTED IONIC LIQUID PHASE (SILP) CATALYST SYSTEMS IN THE HYDROFORMYLATION OF OLEFIN-CONTAINING MIXTURES TO ALDEHYDE MIXTURES WITH A HIGH CONTENT OF ALDEHYDES UNBRANCHED IN THE 2 POSITION
  申请人：Franke Robert

  公开号：US20130289313A1

  公开（公告）日：2013-10-31

  The present invention provides a composition comprising: a) an inert porous support material, b) an ionic liquid, c) a metal selected from group 9 of the Periodic Table of the Elements, d) a phosphorus-containing organic ligand, e) at least one organic amine. The present invention further provides a process for hydroformylating olefin-containing hydrocarbon mixtures to aldehydes with addition of the inventive composition as a catalytically active composition, wherein: a) the water content of the olefin-containing hydrocarbon mixture is adjusted to not more than 20 ppm, b) the content of polyunsaturated compounds in the olefin-containing hydrocarbon mixture is adjusted to not more than 3000 ppm, c) a molar ratio of organic amines according to claims 10 - 13 to phosphorus-containing organic ligands according to claims 8 - 9 of at least 4:1 is established, d) a molar ratio of phosphorus-containing organic ligands according to claims 8 - 9 to rhodium of at least 10:1 is established.
• US7183411B2
  申请人：——

  公开号：US7183411B2

  公开（公告）日：2007-02-27