8-(dimethylamino)-N,N,N-trimethylnaphthalen-1-aminium trifluoromethanesulfonate | 1469537-99-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 8-(dimethylamino)-N,N,N-trimethylnaphthalen-1-aminium trifluoromethanesulfonate
• CAS: 1469537-99-2
• 化学式: CF₃O₃S*C₁₅H₂₁N₂
• 分子量: 378.416
• InChiKey: GKKBPJRROZDCIN-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  3.15
• 重原子数：
  25.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  60.44
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  溴丁基-镁 、 8-(dimethylamino)-N,N,N-trimethylnaphthalen-1-aminium trifluoromethanesulfonate 在 iron(III)-acetylacetonate 作用下， 以 四氢呋喃 、 N-甲基吡咯烷酮 为溶剂， 反应 0.17h， 以55%的产率得到8-butyl-N,N-dimethylnaphthalen-1-amine
  参考文献：
  名称：

  Iron-catalyzed cross-coupling of aryltrimethylammonium triflates and alkyl Grignard reagents

  摘要：

  Fe(acac)(3) effectively catalyzes reaction of aryltrimethylammonium triflates with beta-hydrogen-containing primary or secondary alkyl Grignard reagents in a mixed solvent of THF and NMP at room temperature. A series of functional groups are tolerated under the reaction conditions. (c) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.09.039
• 作为产物：
  描述：

  1,8-双二甲氨基萘 、 三氟甲烷磺酸甲酯 以 二氯甲烷 为溶剂， 反应 4.0h， 以70%的产率得到8-(dimethylamino)-N,N,N-trimethylnaphthalen-1-aminium trifluoromethanesulfonate
  参考文献：
  名称：

  Iron-catalyzed cross-coupling of aryltrimethylammonium triflates and alkyl Grignard reagents

  摘要：

  Fe(acac)(3) effectively catalyzes reaction of aryltrimethylammonium triflates with beta-hydrogen-containing primary or secondary alkyl Grignard reagents in a mixed solvent of THF and NMP at room temperature. A series of functional groups are tolerated under the reaction conditions. (c) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.09.039

文献信息

• Nickel-catalyzed cross-coupling of aryl or 2-menaphthyl quaternary ammonium triflates with organoaluminum reagents
  作者：Fang He、Zhong-Xia Wang

  DOI：10.1016/j.tet.2017.06.004

  日期：2017.7

  The cross-coupling of aryltrimethylammonium triflates with AlMe3 and β-H-containing trialkylaluminums was performed in dioxane at 110 °C under catalysis of (dppp)NiCl2 to afford alkylated arenes. The cross-coupling of 2-menaphthyltrimethylammonium triflate with trialkylaluminums and 1-naphthyltrimethylammonium triflate with triarylaluminums was also carried out respectively under the same conditions

  芳基三甲基铵三氟甲磺酸酯与AlMe 3和含β-H的三烷基铝的交叉偶联是在二恶烷中，在（dppp）NiCl 2的催化下，在110°C下进行的，从而得到烷基化的芳烃。三氟甲磺酸2-萘基三甲基铵与三烷基铝的交叉偶联和三氟甲磺酸1-萘基三甲基铵与三芳基铝的交叉偶联也分别进行。