1-((2-(3-氯-4-乙氧基苯基)-2-甲基丙氧基)甲基)-3-苯氧基-苯 | 80853-81-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-((2-(3-氯-4-乙氧基苯基)-2-甲基丙氧基)甲基)-3-苯氧基-苯
• 中文别名: 2-氯-4-{1,1-二甲基-2-[(3-苯氧基苯甲基)氧代]乙基}-1-乙氧基苯
• 英文名称: 3-phenoxybenzyl 2-(3-chloro-4-ethoxyphenyl)-2-methylpropyl ether
• 英文别名: 4-ethoxy-3-chloroneophyl m-phenoxybenzyl ether；2-chloro-1-ethoxy-4-[2-methyl-1-[(3-phenoxyphenyl)methoxy]propan-2-yl]benzene
• CAS: 80853-81-2
• 化学式: C₂₅H₂₇ClO₃
• 分子量: 410.941
• InChiKey: PLGYQISBTYZBSZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-((2-(3-氯-4-乙氧基苯基)-2-甲基丙氧基)甲基)-3-苯氧基-苯 生成 3-phenoxybenzyl 2-(3-chloro-4-hydroxyphenyl)-2-methylpropyl ether
  参考文献：
  名称：

  NUMATA, SATOSHI;KITAJIMA, KOUJI;KODAKA, KENJI;FUKUSHI, YUKIHARU;SHIRAISHI+

  摘要：

  DOI：
• 作为产物：
  描述：

  3-phenoxybenzyl 2-(3-chloro-4-hydroxyphenyl)-2-methylpropyl ether 、 硫酸二乙酯 生成 1-((2-(3-氯-4-乙氧基苯基)-2-甲基丙氧基)甲基)-3-苯氧基-苯
  参考文献：
  名称：

  UMEMOTO, MITSUMASA;ASANO, TAMOTSU;NAGATA, TERUYUKI;NUMATA, SATOSHI

  摘要：

  DOI：

文献信息

• Insecticidal resin coating film
  申请人：Mitsui Toatsu Chemicals, Inc.

  公开号：US04818525A1

  公开（公告）日：1989-04-04

  An insecticidal resin coating film comprising a combination of an acrylonitrile and/or methacrylonitrile copolymer resin and an insecticidal component selected from the group consisting of specified compounds exhibits an insecticidal effect, since the compound is kept on the surface of the coating film in a state capable of exhibiting its insecticidal effect for a long period of time.

  一种含有丙烯腈和/或甲基丙烯腈共聚物树脂和从指定化合物组成的昆虫杀虫成分中选择的组合的杀虫树脂涂膜，由于该化合物被保持在涂膜表面上，能够长时间展现其杀虫效果。
• Process for producing p-hydroxyneophyl m-phenoxybenzyl ether
  申请人：Mitsui Toatsu Chemicals, Incorporated

  公开号：US05144083A1

  公开（公告）日：1992-09-01

  A process for producing a p-hydroxyneophyl m-phenoxybenzyl ether represented by the general formula (II) ##STR1## (X.sub.1 and X.sub.2 are independently a hydrogen atom or a halogen atom) by subjecting a corresponding p-alkoxyneophyl m-phenoxybenzyl ether represented by the general formula (I) ##STR2## (R represents a lower alkyl group, and X.sub.1 and X.sub.2 have the same definitions as above) to ether cleavage, in which process the ether cleavage reaction is effected in an aprotic polar solvent, using a lower alkoxide of an alkali metal or an alkaline earth metal or using a metal hydroxide in the presence of a lower alcohol.

  通过在无水极性溶剂中使用碱金属或碱土金属的较低烷氧化物，或在存在较低醇的情况下使用金属氢氧化物，将由通用式（I）表示的相应的p-烷氧基新亚基m-苯氧基苄醚（R代表较低烷基，X.sub.1和X.sub.2具有与上述相同的定义）进行醚解离，从而制备由通用式（II）表示的p-羟基新亚基m-苯氧基苄醚（X.sub.1和X.sub.2独立地为氢原子或卤原子）的方法。
• Difluorobromomethoxyphenyl derivative and miticide comprising said
  申请人：Mitsui Toatsu Chemicals, Inc.

  公开号：US04782094A1

  公开（公告）日：1988-11-01

  A difluorobromomethyoxyphenyl derivative of the general formula ##STR1## wherein A represents an oxygen atom or a methylene group, and Y represents a hydrogen or fluorine atom. A miticide comprising the above derivative as an active ingredient is also provided.

  提供一种通式为##STR1##的二氟溴甲氧基苯衍生物，其中A代表氧原子或亚甲基基团，Y代表氢原子或氟原子。还提供了一种以上述衍生物为活性成分的杀螨剂。
• Process for producing 3-phenoxybenzyl 2-(4-alkoxyphenyl)-2-methylpropyl
  申请人：Mitsui Toatsu Chemicals, Inc.

  公开号：US04542243A1

  公开（公告）日：1985-09-17

  The present invention relates to a process for producing 3-phenoxybenzyl 2-(4-alkoxyphenyl)-2-methylpropyl ethers having excellent insecticidal and acaricidal activities which are represented by formula (IV): ##STR1## wherein R is a lower alkyl group and X.sub.1 and X.sub.2 are each a hydrogen or fluorine atom, which comprises reacting a 3-halogeno-4-alkoxyneophyl halide represented by the formula (I): ##STR2## wherein Y.sub.1 and Y.sub.2 are each a hydrogen, chlorine or bromine atom, at least one of them being a chlorine or bromine atom, R has the same meaning as above and X is a halogen atom, with a 3-phenoxybenzyl alcohol represented by the formula (II): ##STR3## wherein X.sub.1 and X.sub.2 have the same meaning as above, in the presence of a base to obtain a 3-phenoxybenzyl 2-(4-alkoxy-3-halogenophenyl)-2-methylpropyl ether represented by the formula (III): ##STR4## wherein Y.sub.1, Y.sub.2, R, X.sub.1 and X.sub.2 have the same meaning as above, and then subjecting the product to a hydrodehalogenation reaction, and relates to a process for producing a 3-halogeno-4-alkoxyneophyl halide represented by formula (I), which comprises reacting a 2-halogeno-1-alkoxybenzene represented by formula (V): ##STR5## wherein Y.sub.1 and Y.sub.2 are each a hydrogen, chlorine or bromine atom, at least one of them being a chlorine or bromine atom, and R represents a lower alkyl group, with a methallyl halide in the presence of an acid catalyst at -20.degree. to 50.degree. C.

  本发明涉及一种生产具有优异杀虫和杀螨活性的3-苯氧基苄基2-(4-烷氧基苯基)-2-甲基丙基醚的方法，其化学式为(IV)：##STR1## 其中，R为低碳基，X1和X2分别为氢或氟原子，其包括通过反应式(I)所表示的3-卤代-4-烷氧基新环烷卤化物：##STR2## 其中，Y1和Y2分别为氢、氯或溴原子，其中至少一个为氯或溴原子，R具有上述相同的含义，X为卤素原子，与式(II)所表示的3-苯氧基苄醇：##STR3## 其中，X1和X2具有上述相同的含义，在碱的存在下，获得式(III)所表示的3-苯氧基苄基2-(4-烷氧基-3-卤苯基)-2-甲基丙基醚：##STR4## 其中，Y1、Y2、R、X1和X2具有上述相同的含义，然后将产物进行脱卤反应，以及一种生产式(I)所表示的3-卤代-4-烷氧基新环烷卤化物的方法，其包括通过反应式(V)所表示的2-卤代-1-烷氧基苯与甲烯丙基卤化物在-20℃至50℃的酸催化剂存在下反应，其中，Y1和Y2分别为氢、氯或溴原子，其中至少一个为氯或溴原子，R表示低碳基。
• Process for preparation of 3-phenoxybenzyl
  申请人：Mitsui Toatsu Chemicals, Inc.

  公开号：US04873373A1

  公开（公告）日：1989-10-10

  Disclosed is a process for preparing 3-phenoxybenzyl 2-(4-alkoxyphenyl)-2-methylpropyl ethers represented by the following formula (I): ##STR1## wherein R stands for a lower alkyl group, and X.sub.1 and X.sub.2 stand for a hydrogen atom or fluorine atom, which comprises subjecting a 3-phenoxybenzyl 2-(4-alkoxy-3-halogenophenyl)-2-methylpropyl ether or 3-phenoxybenzyl-2-(4-alkoxy-3,5-dihalogenophenyl)-2-methylpropyl ether represented by the following formula (II): ##STR2## wherein R stands for a lower alkyl group, X.sub.1 and X.sub.2 stand for a hydrogen atom or fluorine atom, and Y.sub.1 and Y.sub.2 stand for a hydrogen atom, chlorine atom, bromine atom or iodine atom, with the proviso that at least one of Y.sub.1 and Y.sub.2 is a chlorine atom, bromine atom or iodine atom, to dechlorination, debromination or deiodination by hydrogenation, wherein the dechlorination, debromination or deiodination is carried out in the presence of a hydrogenation catalyst by using as a hydrogenative reducing agent a lower aliphatic alcohol and an alkali compound selected from the group comprising alkali metal hydroxides and alkaline earth metal hydroxides. According to this process, compounds of the formula (I) can be obtained in high yields with safety without using hydrogen.

  本发明公开了一种制备下式（I）所示的3-苯氧基苯基2-（4-烷氧基苯基）-2-甲基丙基醚的方法：##STR1## 其中R代表低碳基，X1和X2代表氢原子或氟原子，包括将下式（II）所示的3-苯氧基苯基2-（4-烷氧基-3-卤代苯基）-2-甲基丙基醚或3-苯氧基苯基2-（4-烷氧基-3,5-二卤代苯基）-2-甲基丙基醚：##STR2## 其中R代表低碳基，X1和X2代表氢原子或氟原子，Y1和Y2代表氢原子、氯原子、溴原子或碘原子，但至少其中之一为氯原子、溴原子或碘原子，经过脱氯、脱溴或脱碘反应制得。脱氯、脱溴或脱碘反应在氢化催化剂存在下进行，使用低碳基醇和碱金属羟化物或碱土金属羟化物作为氢化还原剂。根据该方法，可以在不使用氢气的情况下安全地高产得到式（I）化合物。