4-chloro-N-isopropyl-N-methylaniline

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-chloro-N-isopropyl-N-methylaniline
• 英文别名: 4-chloro-N-methyl-N-propan-2-ylaniline
• 化学式: C₁₀H₁₄ClN
• 分子量: 183.681
• InChiKey: ZABSADPYOZOTDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  四氢吡喃 、 4-chloro-N-isopropyl-N-methylaniline 在 叔丁基过氧化氢 、 水 、 copper(II) bis(trifluoromethanesulfonate) 作用下， 以 neat (no solvent) 为溶剂， 反应 36.0h， 以61%的产率得到9-chloro-6-isopropyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline
  参考文献：
  名称：

  Cu-catalyzed oxidative Povarov reactions between N-alkyl N-methylanilines and saturated oxa- and thiacycles

  摘要：

  Cu催化的氧化Povarov反应介于N,N-二烷基苯胺和饱和的氧杂环或硫杂环之间，使用叔丁基过氧化氢(TBHP)。

  DOI：

  10.1039/c5cc01287b
• 作为产物：
  描述：

  4-氯-N-甲基苯胺 、 丙酮 在 三乙胺-硼烷 作用下， 以 neat (no solvent) 为溶剂， 60.0 ℃ 、101.33 kPa 条件下， 反应 24.0h， 以52%的产率得到4-chloro-N-isopropyl-N-methylaniline
  参考文献：
  名称：

  使用 BH3N(C2H5)3 作为还原剂对酮/醛与胺进行还原胺化

  摘要：

  在此，我们报告了使用 BH 3 N(C 2 H 5 ) 3作为催化剂和还原剂在温和条件下用胺有效还原胺化酮/醛的第一个例子，以优异的产率提供各种叔胺和仲胺。机理研究表明，BH 3 N(C 2 H 5 ) 3具有促进亚胺和亚胺形成以及在还原胺化中作为还原剂的双重作用。

  DOI：

  10.1039/d1cc02618f

文献信息

• INHIBITORS OF ION CHANNELS
  申请人：Wang Xiaodong

  公开号：US20070135493A1

  公开（公告）日：2007-06-14

  Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.

  本发明提供了在治疗疾病中有用的化合物、组合物和方法，通过抑制电压门控钠通道中的钠离子通量。更具体地，本发明提供了取代芳基磺酰胺、包含这些化合物的组合物以及使用这些化合物或组合物治疗中枢或外周神经系统疾病，尤其是疼痛和慢性疼痛的方法，通过阻断与所示条件的发生或复发相关的钠通道。本发明的化合物、组合物和方法特别适用于通过抑制电压门控钠通道中的离子通量来治疗神经病理性或炎性疼痛。
• 2-substituted-4-heteroaryl-pyrimidines useful for the treatment of proliferative disorders
  申请人：Wang Shudong

  公开号：US20090137572A1

  公开（公告）日：2009-05-28

  The present invention relates to selected substituted pyrimidines their preparation, pharmaceutical compositions containing them and their use as inhibitors of one or more protein kinases, and hence their use in the treatment of proliferative disorders, viral disorders and/or other disorders.

  本发明涉及选定的取代嘧啶及其制备方法，含有它们的制药组合物以及它们作为一种或多种蛋白激酶抑制剂的用途，因此可用于治疗增殖性疾病、病毒性疾病和/或其他疾病。
• Compositions and methods for inhibiting influenza RNA polymerase PA endonuclease
  申请人：The Regents of the University of California

  公开号：US10889556B2

  公开（公告）日：2021-01-12

  There are provided inter alia metalloenzyme inhibitors, such as inhibitors of influenza A RNA dependent RNA polymerase PA subunit endonuclease, and methods of synthesis and use of the same.

  除其他外，还提供了金属酶抑制剂，例如甲型流感 RNA 依赖性 RNA 聚合酶 PA 亚基内切酶抑制剂，以及合成和使用这些抑制剂的方法。
• Antiparkinsonian Action of Phenylisopropylamines
  申请人：Caron G. Marc

  公开号：US20070027208A1

  公开（公告）日：2007-02-01

  A method of treating a subject for Parkinson's disease comprises administering said subject a phenylisopropylamine in an amount effective to treat said Parkinson's disease. In some embodiments the method is used to treat at least a motor symptom of Parkinson's disease; in some embodiments the method is used to treat at least a non-motor symptom of Parkinson's disease.
• Inhibitors of post-proline cleaving proteases
  申请人：Evans David M.

  公开号：US20080255126A1

  公开（公告）日：2008-10-16

  Novel compounds that are inhibitors of one or most post-proline cleaving proteases, e.g. dipeptidyl peptidase IV, according to general formula (1). R 1 is H or CN, X 1 is O, S, CH 2 , CHF, CF 2 , CH(CH 3 ), C(CH 3 ) 2 or CH(CN), and b is 1 or 2. G 1 is H or a group according to the formula —CH 2 —X 2 —(CH 2 ) a -G 3 and G 2 is H or a group according to the formula —CH 2 —(CH 2 9 a -G 3 , provided that one of G 1 and G 2 is H and the other is not H. X 2 is O, S, or CH 2 , and a is 0, 1 or 2, provided that when a is 1 then X 2 is CH 2 . G 3 is a group according to one of general formulae 2-4, where the variables have meaning given in the description. The compounds are useful in the treatment of i.a. type 2 diabetes and impaired glucose tolerance.