2,4,6-triphenylthiopyrylium ion | 18342-83-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫吡喃类
• 英文名称: 2,4,6-triphenylthiopyrylium ion
• 英文别名: 2,4,6-Triphenyl-thiopyrylium；2,4,6-Triphenylthiopyrylium
• CAS: 18342-83-1
• 化学式: C₂₃H₁₇S
• 分子量: 325.454
• InChiKey: WNWXXQTUESDFIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.03
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  2,4,6-triphenylthiopyrylium ion 在 甲醇 、 sodium methylate 作用下， 以81%的产率得到2-Methoxy-2,4,6-triphenyl-2H-thiopyran
  参考文献：
  名称：

  Fischer, Gerhard W.; Zimmermann, Thomas, Zeitschrift fur Chemie, 1983, vol. 23, # 9, p. 333 - 334

  摘要：

  DOI：
• 作为产物：
  描述：

  2-Methoxy-2,4,6-triphenyl-2H-thiopyran 在 氢气 作用下， 生成 2,4,6-triphenylthiopyrylium ion
  参考文献：
  名称：

  Fischer, Gerhard W.; Zimmermann, Thomas, Zeitschrift fur Chemie, 1983, vol. 23, # 9, p. 333 - 334

  摘要：

  DOI：
• 作为试剂：
  描述：

  trans-4-methyl-2,2,3-triphenylthietane 、 茴香烯 在 2,4,6-triphenylthiopyrylium ion 作用下， 以 乙腈 为溶剂， 反应 0.5h， 以38%的产率得到(1R,3R,4S)-3-methyl-1,4-diphenyl-3,4-dihydro-1H-isothiochromene
  参考文献：
  名称：

  Photoinduced Electron-Transfer Cycloreversion of Thietanes: The Role of Ion−Molecule Complexes

  摘要：

  Cycloreversion (CR) of thietane radical cations leads to formation of thiobenzophenone and the corresponding alkenes, eventually followed by secondary [4 + 2] cycloaddition. Final product distribution depends on the ability of fragments to escape from ion molecule complexes (IMCs).

  DOI：

  10.1021/ol100520m

文献信息

• Photosensitive lithographic printing plate
  申请人：NIPPON OIL AND FATS COMPANY, LIMITED

  公开号：EP0196561A1

  公开（公告）日：1986-10-08

  A photosensitive lithographic printing plate is provided. The printing plate contains a supporting substrate and a photosensitive layer carried on the substrate. The photosensitive layer contains a polymer having an acid number of not more than 200, an addition polymerizable compound having at least one ethylenically unsaturated double bond, an organic peroxide and a compound absorbind visible light.

  提供一种感光平版印刷板。印版包含一个支撑基板和一个承载在基板上的感光层。感光层包含酸数不超过 200 的聚合物、至少有一个乙烯不饱和双键的可加成聚合化合物、有机过氧化物和可吸收可见光的化合物。
• Thiapyrylium dyes useful as anti-cancer agents
  申请人：DANA FARBER CANCER INSTITUTE

  公开号：EP0294921A2

  公开（公告）日：1988-12-14

  There are described an anti-cancer composition and a method of manufacture of a medicament for treating differentiated carcinomas or melanoma, featuring the combination of a suitable carrier and particular 2,4,6-tri(aryl or heteroaryl) thiapyrylium dyes.

  本文介绍了一种抗癌组合物和一种治疗分化癌或黑色素瘤的药物制造方法，其特点是将合适的载体与特定的 2,4,6-三（芳基或杂芳基）硫apyrylium 染料相结合。
• Pharmaceutical compositions containing pyrylium compounds, pyrylium salts and process for manufacturing a medicament containing the aforesaid compounds
  申请人：CANON KABUSHIKI KAISHA

  公开号：EP0659407A1

  公开（公告）日：1995-06-28

  The present invention provides pharmaceutical compositions containing a pyrylium compound, a thiopyrylium compound, a selenopyrylium compound or a telluropyrylium compound or a salt of any of the aforesaid compounds as active ingredient. The compounds are selectively absorbed by cancer cells or similar growths in the human or animal body and can be used to bring about distruction of the unwanted growth on irradiation with light of wavelength 600nm to 1000nm. The invention also provides a method for the treatment of the human or animal body which comprises administering the compound to a human or animal and irradiating a locus in said animal where the compound is absorbed in order to kill cells at that locus. It further comprises the use of the aforesaid compound for the making of a medicament for use in the treatment of cancer in humans and animals.

  本发明提供了含有吡镱化合物、硫吡镱化合物、硒吡镱化合物或碲吡镱化合物或上述任一化合物的盐作为活性成分的药物组合物。这些化合物可被人或动物体内的癌细胞或类似的生长物选择性吸收，在波长为 600nm 至 1000nm 的光照射下，可用于破坏不需要的生长物。 本发明还提供了一种治疗人体或动物体的方法，该方法包括给人或动物施用该化合物，并照射动物体内吸收该化合物的部位，以杀死该部位的细胞。该方法还包括使用上述化合物制造用于治疗人类和动物癌症的药物。
• METHOD FOR PREPARING ENANTIOMER OF SULFOXIDE COMPOUND, AND SYSTEM FOR PREPARING ENANTIOMER
  申请人：Tokyo University of Science Foundation

  公开号：EP4015044A1

  公开（公告）日：2022-06-22

  Provided is an enantiomer preparation method in which one enantiomer of a sulfoxide compound is selectively prepared, the sulfoxide compound having a sulfur atom of a sulfoxide group as an asymmetric center, and the method comprising: a step A for optically resolving an enantiomer mixture of a sulfoxide compound into one enantiomer and the other enantiomer; a step B for irradiating with light the other enantiomer obtained in step A or step C to racemize the enantiomer; and step C for optically resolving the enantiomer mixture of the sulfoxide compound obtained in step B into one enantiomer and the other enantiomer. Also provided is a system for preparing an enantiomer, the system being used in the enantiomer preparation method.

  提供了一种对映体制备方法，其中选择性地制备了一种亚砜化合物的一种对映体，该亚砜化合物具有一个亚砜基团的硫原子作为不对称中心，该方法包括：A 步，将氧化硫化合物的对映体混合物光学解析为一种对映体和另一种对映体； B 步，用光照射步骤 A 或步骤 C 中得到的另一种对映体，使该对映体消旋化；以及 C 步，将步骤 B 中得到的氧化硫化合物的对映体混合物光学解析为一种对映体和另一种对映体。还提供了一种制备对映体的系统，该系统用于对映体制备方法。
• On the Nature of Solvent Effects on Redox Properties
  作者：Heidi Svith、Henrik Jensen、Johan Almstedt、Paula Andersson、Thomas Lundbäck、Kim Daasbjerg、Mats Jonsson

  DOI：10.1021/jp031268q

  日期：2004.5.1

  The one-electron reduction potentials of six radical cations, four cations, and four neutral radicals in tetrahydrofuran, dichloromethane, dimethyl sulfoxide, N-methyl-2-pyrrolidinone, N,N-dimethylformamide, acetonitrile, methanol, ethanol, 2-propanol, acetone, formamide, and 1,1,1,3,3,3-hexafluoropropan-2-ol have been measured by cyclic voltammetry. For 10 of the redox couples, the redox process was reversible in all solvents. These results have been used to evaluate solvent effects by means of the Kamlet-Taft relationship. The relative importance of the solvent parameters alpha, beta, pi*, and delta(H) is 54.9, 9.6, 15.5 and 20.0%, respectively, for the radical cation displaying the strongest solvent dependence. In addition, we have studied the entropy contribution to some of the observed solvent effects by measuring the redox potentials as a function of temperature. The absolute value of the entropy appears to increase with increasing hydrogen bond donor ability of the solvent. The variation in entropy indicates that specific solvation is of main importance when considering solvent effects on redox properties.