superoxide

• 分子结构分类: 无机化合物 - 均质非金属化合物 - 其他非金属有机物
• 英文名称: superoxide
• 英文别名: O2(-)；Oxoniumhydroxyd；oxidanium;hydroxide
• 化学式: O₂
• 分子量: 31.9988
• InChiKey: JEGUKCSWCFPDGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.65
• 重原子数：
  2
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  superoxide 、 americium nitride 以 neat (no solvent) 为溶剂， 生成 americium(IV) oxide
  参考文献：
  名称：

  NMR Evidence for the 8.5 K Phase Transition in Americium Dioxide

  摘要：

  We report here the first NMR study of americium dioxide (AmO2). More than 30 years ago, a phase transition was suggested to occur in this compound at 8.5K based on magnetic susceptibility data, while no evidence had been obtained from microscopic measurements. We have prepared a powder sample of (AmO2)-Am-243 containing 90 at. % O-17 and have performed O-17 NMR at temperatures ranging from 1.5 to 200 K. After a sudden drop of the O-17 NMR signal intensity below 8.5 K, at 1.5 K we have observed an extremely broad spectrum covering a range of similar to 14 kOe in applied field. These data provide the first microscopic evidence for a phase transition as a bulk property in this system. In addition, the O-17 NMR spectrum has been found to split into two peaks in the paramagnetic state, an effect which has not been reported for actinide dioxides studied up to now. We suggest that the splitting is induced by self-radiation damage from the alpha decay of Am-243.

  DOI：

  10.1143/jpsj.79.053705
• 作为产物：
  描述：

  氧气 以 gas 为溶剂， 生成 superoxide
  参考文献：
  名称：

  Rate constants for the reaction of O2+ with NO from 300 to 1400 K

  摘要：

  The rate constants for the charge transfer reaction of O2+ with NO have been measured from 300 to 1400 K using a high temperature flowing afterglow. The current results agree well with the previous flowing afterglow studies made at temperatures up to 900 K. The rate constants have no significant temperature dependence over the entire temperature range. The rate constants are in good agreement with the previous flow drift tube measurements at the same translational temperatures. Any dependence of the rate constant on internal energy is therefore small.

  DOI：

  10.1063/1.479017
• 作为试剂：
  描述：

  1,2-二氯六氟环戊烯 、 对硝基苯酚 、 氢氧化钾 、 水 在 superoxide 、 sodium hydroxide 、 水 、 Sodium sulfate-III 作用下， 以 N,N-二甲基甲酰胺 、 二氯甲烷 为溶剂， 反应 20.0h， 生成 1,2-Bis-(4-nitrophenoxy)-3,3,4,4,5,5-hexafluorocyclopent-1-ene
  参考文献：
  名称：

  Fluorinated bisaryloxy-substituted alkenes, process for their

  摘要：

  新的含氟双芳氧基取代烯烃通过取代的酚与全卤代烷烃反应制备而成，可用作电绝缘剂。

  公开号：

  US04990633A1

文献信息

• Negative Ion Chemistry of Ozone in the Gas Phase
  作者：Skip Williams、Meghann F. Campos、Anthony J. Midey、Susan T. Arnold、Robert A. Morris、Albert A. Viggiano

  DOI：10.1021/jp012929r

  日期：2002.2.1

  was developed to study the negative ion chemistry of ozone in the gas phase. Rate constants and product ion branching fractions are reported for 17 negative ion-molecule reactions involving ozone (O 3 ). This is the most comprehensive set of O 3 reactions with negative ions to date. The reactions proceed primarily through charge transfer and O atom transfer. The reaction rate constants for O - , O

  开发了一种新型臭氧源来研究臭氧在气相中的负离子化学。报告了 17 个涉及臭氧 (O 3 ) 的负离子分子反应的速率常数和产物离子支化分数。这是迄今为止最全面的与负离子的 O 3 反应。反应主要通过电荷转移和O原子转移进行。O - 、O 2 - 和 OH- 的反应速率常数很大，大约等于基于平均偶极子取向理论的 Su-Chesnavich 方程给出的热能捕获速率常数。负离子 NO 2 - 、CO 4 - 、SF 6 - 和 PO 2 - 的反应性稍差，以大约 20-50% 的热捕获率反应。氢氟烃离子 CF 3 - 和 C 2 F 5 - 以 80% 的热捕获率反应，F- 是形成的主要产物离子。发现 NO 3 - 、CO 3 - 、PO 3 - 、CF 3 O - 、F - 、Cl- 和 Br- 在速率常数 < 5 × 10 - 1 2 cm 3 s - 1 时不发生反应，即目前我们使用这种臭氧源的设备的检测限。观察到
• Temperature dependence of ternary rate coefficients for the (CO)n−1++2CO⇌(CO)n++CO reaction, and the role of isomers for the growth of larger (CO)n+ clusters
  作者：S. Schlemmer、A. Luca、J. Glosik、D. Gerlich

  DOI：10.1063/1.1451247

  日期：2002.3.15

  Ternary rate coefficients for the title reaction have been measured using a rf 22-pole ion trap in the temperature range 65–300 K. For the formation of dimers, the ternary rate coefficient, k3, follows the power law 2.3×10−28 cm6/s×(300 K/T)m, with m=1.6±0.2 over the full temperature range of the experiment. This result is in good agreement with previous measurements at higher temperatures and also

  标题反应的三元速率系数已使用 22 极射频离子阱在 65–300 K 温度范围内测量。对于二聚体的形成，三元速率系数 k3 遵循幂律 2.3×10-28 cm6 /s×(300 K/T)m，在整个实验温度范围内，m=1.6±0.2。该结果与先前在较高温度下的测量以及理论预测非常一致。三聚体的形成用k3=1.3×10-29 cm6/s×(300 K/T)m表示，m=3.2±0.3。将先前在更高温度下测量的数据纳入评估，会导致更陡峭的温度依赖性。这些发现初步解释为 (CO)2+ 是一种具有低位振动模式的非线性分子。四聚体的形成，(CO)4+，非常慢并且显示出正的或接近零的温度依赖性。这种行为可以通过两种异构体的存在来解释。为了通过这个瓶颈，达到（CO）5+及更大的CL...
• Substituted Bicyclic Aromatic Carboxamide and Urea Compounds as Vanilloid Receptor Ligands
  申请人：FRANK Robert

  公开号：US20130029995A1

  公开（公告）日：2013-01-31

  Substituted bicyclic aromatic carboxamide and urea compounds as vanilloid receptor ligands, pharmaceutical compositions containing these compounds, and a method of using these compounds in the treatment and/or inhibition of pain and further diseases and/or disorders mediated at least in part via the vanilloid receptor 1 (VR1/TRPV1).

  取代的双环芳香基甲酰胺和脲类化合物作为vanilloid受体配体，含有这些化合物的制药组合物，以及使用这些化合物治疗和/或抑制通过vanilloid受体1（VR1 / TRPV1）至少部分介导的疼痛和其他疾病和/或紊乱的方法。
• COMBINATION OF A IMIDAZOPYRIDAZINE DERIVATIVE AND A MITOTIC AGENT FOR THE TREATMENT OF CANCER
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20160175306A1

  公开（公告）日：2016-06-23

  The present invention relates to a combination comprising an Mps-1 kinase inhibitor and a mitotic inhibitor. The present invention also relates to the use of said combination for the treatment of cancer, in particular of pancreatic cancer, glioblastoma, ovarian cancer, non-small cell lung carcinoma, breast cancer and/or gastric cancer.

  本发明涉及一种包含Mps-1激酶抑制剂和有丝分裂抑制剂的组合物。本发明还涉及使用该组合物治疗癌症，特别是胰腺癌、胶质母细胞瘤、卵巢癌、非小细胞肺癌、乳腺癌和/或胃癌的用途。
• SUBSTITUTED IMIDAZOPYRIDAZINES
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20160016959A1

  公开（公告）日：2016-01-21

  The present invention relates to substituted imidazopyridazine compounds, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

  本发明涉及取代咪唑吡啶烷化合物，制备该化合物的方法，包含该化合物的制药组合物和组合物，以及使用该化合物制造用于治疗或预防疾病的制药组合物，特别是用作唯一活性成分或与其他活性成分组合治疗增生和/或血管生成障碍的疾病。