<1-18F>HFC 227ea

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氟化物
• 英文名称: <1-18F>HFC 227ea
• 英文别名: [1-18F]HFC 227ea；1-(18F)fluoranyl-1,1,2,3,3,3-hexafluoropropane
• 化学式: C₃HF₇
• 分子量: 169.031
• InChiKey: YFMFNYKEUDLDTL-SFIIULIVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  七氟丙烷 在 Kryptofix222[18F]钾盐 作用下， 以 乙腈 为溶剂， 反应 0.5h， 生成 六氟丙烯 、 <1-18F>HFC 227ea
  参考文献：
  名称：

  Labelling of the CFC-alternative, 2H-heptafluoropropane (HFC 227ea), with fluorine-18

  摘要：

  Various reactions of no-carrier-added K+-aminopolyether 2.2.2-[F-18]fluoride were examined for labelling the CFC-altemative, 2H-heptafluoropropane (HFC 227ea), with the positron-emitting radioisotope, fluorine-18 (t(1/2) = 109.7 min). Reaction with 2H-hexafluoroisopropyl tosylate incorporated less than 2% of the radioactivity into [2-F-18] HFC 227ea and about 12% into three other volatile products. Reaction with hexafluoropropene led to a high incorporation of fluorine-18 (80%) into four radioactive products, namely the desired [1-F-18] HFC 227ea, [F-18] hexafluoropropene, [F-18] perfluoro-isohex-2-ene and an unknown, in a molar ratio of 5:4:38:3, respectively. Although reaction with 1-iodo-2H-hexafluoropropane gave [1-F-18]HFC 227ea in a much higher radiochemical yield (50% decay-corrected), the best radiochemical yield (80% decay-corrected) was obtained by exchange with HFC 227ea. The mechanistic bases of the results are discussed. An efficient fully shielded and automated procedure was devised for labelling HFC 227ea with fluorine-18 in high radioactivity, based on the successful exchange reaction and GC purification. [1-F-18] HFC 227ea was obtained in high radiochemical purity ( > 99%) and high chemical purity ( > 98.4%) at 80 min from the start of radiosynthesis. This product is suitable for studies of the disposition of HFC 227ea in vivo.

  DOI：

  10.1016/0022-1139(95)03306-x

文献信息

• Labelling of the CFC-alternative, 2H-heptafluoropropane (HFC 227ea), with fluorine-18
  作者：Franklin I. Aigbirhio、Victor W. Pike

  DOI：10.1016/0022-1139(95)03306-x

  日期：1995.11

  Various reactions of no-carrier-added K+-aminopolyether 2.2.2-[F-18]fluoride were examined for labelling the CFC-altemative, 2H-heptafluoropropane (HFC 227ea), with the positron-emitting radioisotope, fluorine-18 (t(1/2) = 109.7 min). Reaction with 2H-hexafluoroisopropyl tosylate incorporated less than 2% of the radioactivity into [2-F-18] HFC 227ea and about 12% into three other volatile products. Reaction with hexafluoropropene led to a high incorporation of fluorine-18 (80%) into four radioactive products, namely the desired [1-F-18] HFC 227ea, [F-18] hexafluoropropene, [F-18] perfluoro-isohex-2-ene and an unknown, in a molar ratio of 5:4:38:3, respectively. Although reaction with 1-iodo-2H-hexafluoropropane gave [1-F-18]HFC 227ea in a much higher radiochemical yield (50% decay-corrected), the best radiochemical yield (80% decay-corrected) was obtained by exchange with HFC 227ea. The mechanistic bases of the results are discussed. An efficient fully shielded and automated procedure was devised for labelling HFC 227ea with fluorine-18 in high radioactivity, based on the successful exchange reaction and GC purification. [1-F-18] HFC 227ea was obtained in high radiochemical purity ( > 99%) and high chemical purity ( > 98.4%) at 80 min from the start of radiosynthesis. This product is suitable for studies of the disposition of HFC 227ea in vivo.