12-propyloxyimino-1,15-pentadecanlactam | 1186485-66-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: 12-propyloxyimino-1,15-pentadecanlactam
• 英文别名: 13-Propoxyimino-azacyclohexadecan-2-one；13-propoxyimino-azacyclohexadecan-2-one
• CAS: 1186485-66-4
• 化学式: C₁₈H₃₄N₂O₂
• 分子量: 310.48
• InChiKey: RIDILXJDPSBBQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  50.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-氯丙烷 、 12-oxo-1,15-pentadecanlactam 在 盐酸羟胺 作用下， 生成 12-propyloxyimino-1,15-pentadecanlactam
  参考文献：
  名称：

  Primary Study on Mode of Action for Macrocyclic Fungicide Candidates (7B3, D1) against Rhizoctonia solani Kühn

  摘要：

  A novel macrolactam fungicide candidate (7B3) and a novel aza-macrolactone fungicide candidate (D1) were designed and synthesized, and the bioassay showed that both displayed excellent fungicidal activity against Rhizoctonia solani Kuhn. To elucidate the biochemical mode of action of the two compounds against R. solani and illustrate the similarities and differences of action mechanism resulting from subtle differences in structure of the two compounds, the effects of the two compounds on the ultrastructure of hyphae, electrolyte leakage, and respiration of mycelia cell suspension caused by 7B3 or D1 were studied. The results showed that the two compounds had very similar modes of action. Both induced irregular swelling of hyphae, vacuolation of cytoplasm, and thickening of cell wall. The conductivity of mycelia cell suspension increased in the presence of 7B3 or D1, which indicated that the two compounds had a similar effect on cell membrane permeability. In addition, both 7B3 and D1 were insufficient in inhibiting the respiration of mycelia.

  DOI：

  10.1021/jf9037369