氟雷拉纳中间体 | 864731-37-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 氟雷拉纳中间体
• 英文名称: (4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylbenzoyl)glycine
• 英文别名: N-[4-[5-(3,5-Dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methylbenzoyl]glycine；2-[[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-2-methylbenzoyl]amino]acetic acid
• CAS: 864731-37-3
• 化学式: C₂₀H₁₅Cl₂F₃N₂O₄
• 分子量: 475.251
• InChiKey: FLSLJCITJHGBRN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  88
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  氟雷拉纳中间体 、 2,2,2-三氟乙基胺 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 以75.5%的产率得到氟雷拉纳
  参考文献：
  名称：

  [EN] PROCESS FOR PREPARING FLURALANER
  [FR] PROCÉDÉ DE PRÉPARATION DE FLURALANER

  摘要：

  本发明涉及一种以高效和经济的方式合成Fluralaner的改进方法。

  公开号：

  WO2021122356A1
• 作为产物：
  描述：

  2-(4-acetyl-2-methylbenzamide)acetic acid 在 盐酸羟胺 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 1,4-二氧六环 、 水 、 甲苯 为溶剂， 反应 8.0h， 生成 氟雷拉纳中间体
  参考文献：
  名称：

  [EN] A PROCESS FOR THE PREPARATION OF CARBAMOYL BENZAMIDE PHENYL ISOXAZOLINE CLASS DRUG/S AND ITS INTERMEDIATES
  [FR] PROCÉDÉ POUR PRÉPARER DES MÉDICAMENTS DE CLASSE D'ISOXAZOLINE PHÉNYL-BENZAMIDE ET DE SES INTERMÉDIAIRES

  摘要：

  The present invention provides a process for the preparation of a compound of Formula I, wherein, # indicates the attachment to isoxazoline ring and * indicates the attachment to the carbonyl carbon, The present invention particularly provides the process for the preparation of Fluralaner, Afoxolaner or Lotilaner, which is high yielding, which gives high purity, and which is environment-friendly.

  公开号：

  WO2023012821A1

文献信息

• [EN] ISOXAZOLINE SOLUTION CONTAINING VITAMIN E FOR USE WITH SANITIZED DRINKING WATER<br/>[FR] SOLUTION D'ISOXAZOLINE CONTENANT DE LA VITAMINE E POUR UNE UTILISATION AVEC DE L'EAU POTABLE DÉSINFECTÉE
  申请人：INTERVET INT BV

  公开号：WO2016207234A1

  公开（公告）日：2016-12-29

  For the prevention of parasite infestation of animals, an isoxazoline can be administered by drinking water route. However the inventors have found that when the drinking water is sanitized, for instance by using hypochlorite, the isoxazoline becomes degraded. Surprisingly, the isoxazoline can be protected from degradation by the use of a vitamin E. A pharmaceutical composition can now be prepared containing a concentrated solution of the isoxazoline in a solvent and co-solvent, with vitamin E. The composition can be diluted in drinking water, even when sanitized, to prepare medicated drinking water for animals. This way an anti-parasitic treatment can be mass-administered, leading to a highly effective reduction of the parasite infestation of an animal, and its surroundings.

  为了预防动物寄生虫感染，可以通过饮用水途径给予异噁唑啉。然而，发明者发现当饮用水被消毒，例如使用次氯酸盐时，异噁唑啉会被降解。令人惊讶的是，维生素E的使用可以保护异噁唑啉免受降解。现在可以制备一种含有异噁唑啉浓缩溶液和溶剂、共溶剂以及维生素E的药物组合物。即使经过消毒，该组合物也可以被稀释在饮用水中，以制备用于动物的药物饮用水。通过这种方式，可以进行抗寄生虫治疗的大规模给药，从而高效地减少动物及其周围环境中寄生虫的感染。
• Isoxazoline-substituted benzamide compound and pesticide
  申请人：Mita Takeshi

  公开号：US20070066617A1

  公开（公告）日：2007-03-22

  An isoxazoline-substituted benzamide compound of formula (1) or a salt thereof: wherein A 1 , A 2 and A 3 independently of one another are carbon atom or nitrogen atom, G is benzene ring, etc., X is halogen atom, C 1 -C 6 haloalkyl, etc., Y is halogen atm, C 1 -C 6 alkyl, etc., R 1 is C 1 -C 12 alkyl arbitrarily substituted with R 16 , C 3 -C 2 alkenyl, arbitrarily substituted with R 16 is oxygen atom or sulfur atom, —N(R 20 )R 19 , etc., R 2 is hydrogen atom, C 1 -C 4 alkoxy C 1 -C 6 alkyl, etc., R 3 is C 1 -C 6 haloalkyl, etc., R 16 is halogen atom, cyano, phenyl substituted with (Z) p1 , D-1 to D-60, E-1 to E-49, etc., R 19 is phenyl, phenyl substituted with (Z) p1 , etc., R 20 is hydrogen atom, C 1 -C 6 alkyl, etc., Z is halogen atom, nitro, C 1 -C 4 alkoxy, etc., D-1 to D-60 are 5- or 6-membered aromatic heterocyclic rings, E-1 to E-49 are 5- or 6-membered saturated heterocyclic rings, m is an integer of 0 to 5, n is an integer of 0 to 4, p1 is an integer of 1 to 5. The pesticide containing these compounds.

  一种公式（1）所示的异噁唑基取代的苯甲酰胺化合物或其盐： 其中A1，A2和A3独立地为碳原子或氮原子，G为苯环等，X为卤素原子，C1-C6卤代烷基等，Y为卤素原子，C1-C6烷基等，R1是任意取代的C1-C12烷基，或者任意取代的C3-C2烯基，取代基为R16，R16是卤素原子，氰基，苯基取代的（Z）p1，D-1至D-60，E-1至E-49等，R2为氢原子，C1-C4烷氧基C1-C6烷基等，R3为C1-C6卤代烷基等，R19为苯基，苯基取代的（Z）p1等，R20为氢原子，C1-C6烷基等，Z为卤素原子，硝基，C1-C4烷氧基等，D-1至D-60为5-或6-成员芳香杂环环，E-1至E-49为5-或6-成员饱和杂环，m为0至5的整数，n为0至4的整数，p1为1至5的整数。包含这些化合物的杀虫剂。
• ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE
  申请人：Mita Takeshi

  公开号：US20090312330A1

  公开（公告）日：2009-12-17

  An isoxazoline-substituted benzamide compound of formula (1) or a salt thereof: wherein A 1 , A 2 and A 3 independently of one another are carbon atom or nitrogen atom, G is benzene ring, etc., X is halogen atom, C 1 -C 6 haloalkyl, etc., Y is halogen atm, C 1 -C 6 alkyl, etc., R 1 is C 1 -C 12 alkyl arbitrarily substituted with R 16 , C 3 -C 12 alkenyl, arbitrarily substituted with R 16 is oxygen atom or sulfur atom, —N(R 20 )R 19 , etc., R 2 is hydrogen atom, C 1 -C 4 alkoxy C 1 -C 6 alkyl, etc., R 3 is C 1 -C 6 haloalkyl, etc., R 16 is halogen atom, cyano, phenyl substituted with (Z) p1 , D-1 to D-60, E-1 to E-49, etc., R 19 is phenyl, phenyl substituted with (Z) p1 , etc., R 20 is hydrogen atom, C 1 -C 6 alkyl, etc., Z is halogen atom, nitro, C 1 -C 4 alkoxy, etc., D-1 to D-60 are 5- or 6-membered aromatic heterocyclic rings, E-1 to E-49 are 5- or 6-membered saturated heterocyclic rings, m is an integer of 0 to 5, n is an integer of 0 to 4, p1 is an integer of 1 to 5. The pesticide containing these compounds.

  一种公式（1）的异氧杂环取代苯甲酰胺化合物或其盐： 其中，A1，A2和A3独立地是碳原子或氮原子，G是苯环等，X是卤素原子，C1-C6卤代烷基等，Y是卤素原子，C1-C6烷基等，R1是任意取代R16的C1-C12烷基，任意取代R16的C3-C12烯基，是氧原子或硫原子，-N（R20）R19等，R2是氢原子，C1-C4烷氧基C1-C6烷基等，R3是C1-C6卤代烷基等，R16是卤素原子，氰基，苯基，其上取代有（Z）p1，D-1至D-60，E-1至E-49等，R19是苯基，其上取代有（Z）p1等，R20是氢原子，C1-C6烷基等，Z是卤素原子，硝基，C1-C4烷氧基等，D-1至D-60是5-或6-成员芳香杂环，E-1至E-49是5-或6-成员饱和杂环，m是0至5的整数，n是0至4的整数，p1是1至5的整数。含有这些化合物的杀虫剂。
• 一种醛肟类化合物及其制备方法和应用
  申请人：四川青木制药有限公司

  公开号：CN114907236A

  公开（公告）日：2022-08-16

  本发明公开了一种如式Ⅳ化合物及其制备方法，以及所述化合物在制备氟雷拉纳药物中的应用。本发明带来的有益效果有：合成原料廉价易得，中间体制备条件温和，操作安全，对环境污染小，更适合工业化大规模生产。
• Isoxazoline solution containing vitamin E for use with sanitized drinking water
  申请人：Intervet Inc.

  公开号：US11179372B2

  公开（公告）日：2021-11-23

  For the prevention of parasite infestation of animals, an isoxazoline can be administered by drinking water route. However the inventors have found that when the drinking water is sanitized, for instance by using hypochlorite, the isoxazoline becomes degraded. Surprisingly, the isoxazoline can be protected from degradation by the use of a vitamin E. A pharmaceutical composition can now be prepared containing a concentrated solution of the isoxazoline in a solvent and co-solvent, with vitamin E. The composition can be diluted in drinking water, even when sanitized, to prepare medicated drinking water for animals. This way an anti-parasitic treatment can be mass-administered, leading to a highly effective reduction of the parasite infestation of an animal, and its surroundings.

  为预防动物寄生虫感染，可通过饮用水途径施用异噁唑啉。然而，发明者发现，当对饮用水进行消毒（例如使用次氯酸盐）时，异噁唑啉就会降解。现在可以制备出一种药物组合物，其中含有异噁唑啉在溶剂和辅助溶剂中的浓缩溶液以及维生素 E。这样就可以大规模地进行抗寄生虫治疗，从而非常有效地减少动物及其周围环境中的寄生虫感染。