benzyl(3-methoxypropyl)dimethylsilane | 145675-44-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl(3-methoxypropyl)dimethylsilane
• 英文别名: Benzyl-(3-methoxypropyl)-dimethylsilane；benzyl-(3-methoxypropyl)-dimethylsilane
• CAS: 145675-44-1
• 化学式: C₁₃H₂₂OSi
• 分子量: 222.403
• InChiKey: WCZYVJVHJBSDJK-UHFFFAOYSA-N

物化性质

• 沸点：
  258.5±15.0 °C(Predicted)
• 密度：
  0.900±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.51
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  烯丙基甲基醚 、 苄基二甲基硅烷 在 bis(1,5-cyclooctadiene)diiridium(I) dichloride 作用下， 以 二氯甲烷 为溶剂， 以96%的产率得到benzyl(3-methoxypropyl)dimethylsilane
  参考文献：
  名称：

  Iridium-Catalyzed Hydrosilylation of Unactivated Alkenes: Scope and Application to Late-Stage Functionalization

  摘要：

  Highly efficient and general Ir-catalyzed hydrosilylation of unactivated alkenes with excellent anti-Markovnikov regioselectivity was described. A broad scope of hydrosilylated products were synthesized economically and conveniently from commercially or naturally available compounds, which provides versatile valuable precursors for organic and medicinal studies.

  DOI：

  10.1021/acs.joc.8b02838

文献信息

• Generation of anionic intermediates by intramolecular nucleophilic attack at silicon
  作者：Paul F. Hudrlik、Yousef M. Abdallah、Anne M. Hudrlik

  DOI：10.1016/s0040-4039(00)61766-5

  日期：1992.11

  Benzyl and allyl anion equivalents can be generated from benzyl- and allylsilanes by intramolecular alkoxide attack.

  苄基和烯丙基阴离子可通过分子内醇盐的攻击从苄基和烯丙基硅烷中生成。
• Iridium-Catalyzed Hydrosilylation of Unactivated Alkenes: Scope and Application to Late-Stage Functionalization
  作者：Xingze Xie、Xueyan Zhang、Haoyu Yang、Xin Ji、Jianing Li、Shengtao Ding

  DOI：10.1021/acs.joc.8b02838

  日期：2019.1.18

  Highly efficient and general Ir-catalyzed hydrosilylation of unactivated alkenes with excellent anti-Markovnikov regioselectivity was described. A broad scope of hydrosilylated products were synthesized economically and conveniently from commercially or naturally available compounds, which provides versatile valuable precursors for organic and medicinal studies.