O,O-二丙基硫代磷酰肼 | 59895-97-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫代磷酸及其衍生物
• 中文名称: O,O-二丙基硫代磷酰肼
• 英文名称: O,O-dipropyl thiophosphorohydrazide
• 英文别名: thiophosphorohydrazidic acid O,O'-dipropyl ester；hydrazidothiophosphoric acid O,O'-dipropyl ester；Hydrazidothiophosphorsaeure-O,O'-dipropylester；O,O'-Dipropyl-hydrazidothiphosphat；Dipropoxyphosphinothioylhydrazine
• CAS: 59895-97-5
• 化学式: C₆H₁₇N₂O₂PS
• 分子量: 212.253
• InChiKey: OWXVCSCNXYYZGD-UHFFFAOYSA-N

物化性质

• 沸点：
  76-80 °C(Press: 0.04 Torr)
• 密度：
  1.1031 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  88.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  O,O-二丙基硫代磷酰肼 、 二乙酰一肟 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 生成 (2-hydroxyimino-1-methyl-propylidene)-thiophosphorohydrazidic acid O,O'-dipropyl ester
  参考文献：
  名称：

  Phosphorus-nitrogen compounds. 20. Thiophosphorus hydrazones

  摘要：

  Six pyridine-2-carboxaldehyde, one pyridine N-oxide 2-carboxaldehyde, and five diketone thiophosphoric hydrazones, three thiophosphoric hydrazides, and two cupric chelates were synthesized. The chelates and nine of the hydrazones were tested against Ehrlich ascites carcinoma. Seven of these latter agents were administered concurrently with either cupric and/or ferrous salts to mice bearing this tumor. The greatest activity was found with the chelate, cimethyl pyridine-2-carboxyaldehyde phosphorothioic hydrazone-copper (1:1). The hydrazone portion of this chelate also formed a ligand-copper (2:1) complex. Although all of the hydrazones but one were inactive when evaluated alone, the concurrent injection of cupric ion increased survival times by an avoli alkaline phosphatase was found to be inhibited by two thiosemicarbazones in a manner similar to that previously reported by these agents against alkaline phosphatase derived from Sarcoma 180-6-thiopurine resistant ascites cells. None of the 14 hydrazides or hydrazones tested against E. coli enzyme displayed significant inhibition.

  DOI：

  10.1021/jm00231a010
• 作为产物：
  描述：

  氯-二丙氧基-巯基膦烷 在 肼 作用下， 生成 O,O-二丙基硫代磷酰肼
  参考文献：
  名称：

  Melnikow; Senkewitsch, Zhurnal Obshchei Khimii, 1955, vol. 25, p. 828,829;engl.Ausg.S.793

  摘要：

  DOI：

文献信息

• An efficient synthesis of O,O- Di Propyl (E)-2-[1-methyl 2-oxopropylidene]phosphorohydrazidothiolate (E) Oxime and Its Analogues: A Potential Marine Toxin
  作者：Arvind K. Gupta、D. K. Dubey、B. D. Parashar、M. P. Kaushik

  DOI：10.1080/10426500701796249

  日期：2008.7.4

  An efficient method for the synthesis of Ptychodiscus brevis toxin O,O- di n-propyl (E)-2-[1-methyl 2-oxopropylidene]phosphorohydrazidothiolate (E) oxime (TG-1) and its analogues has been developed using thermally stable and recyclable silica gel and Na2SO4 as a condensing agent and water scavenger, respectively. The compounds were evaluated against fish Rasbora daniconius by determining the LC50 and LC90 values. The results of biological evaluation showed that these compounds have high degree of toxicity.
• Kaushik, Mahabir P.; Parashar, Brahma D.; Vaidyanathaswamy, Ramamoorthy, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1988, vol. 27, # 1-12, p. 1150 - 1151
  作者：Kaushik, Mahabir P.、Parashar, Brahma D.、Vaidyanathaswamy, Ramamoorthy

  DOI：——

  日期：——
• KAUSHIK, MAHABIR P.;PARASHAR, BRAHMA D.;VAIDYANATHASWAMY, RAMAMOORTHY, INDIAN J. CHEM. B , 27B,(1988) N2, C. 1150-1151
  作者：KAUSHIK, MAHABIR P.、PARASHAR, BRAHMA D.、VAIDYANATHASWAMY, RAMAMOORTHY

  DOI：——

  日期：——
• KONECNY V.; KOVAC S., CHEM. PAP., 40,(1986) N 5, 679-684
  作者：KONECNY V.、 KOVAC S.

  DOI：——

  日期：——
• KONECNY V.; KOVAC S., CHEM. PAP., 40,(1986) N 6, 813-818
  作者：KONECNY V.、 KOVAC S.

  DOI：——

  日期：——