虫螨磷II | 21923-23-9

• 物质功能分类: 化学农药原药 - 杀虫剂 - 有机氯杀虫剂
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫代磷酸及其衍生物
• 中文名称: 虫螨磷II
• 中文别名: 氯甲硫磷；O-(2,5-二氯-4-甲硫基苯基)-O,O-二乙基硫代磷酸酯；O-(2,5-二氯-4-甲硫基苯基)硫代磷酸二乙酯；氯甲硫磷Chlorthiophos
• 英文名称: chlorthiophos
• 英文别名: (2,5-dichloro-4-methylsulfanylphenoxy)-diethoxy-sulfanylidene-λ5-phosphane
• CAS: 21923-23-9；60238-56-4
• 化学式: C₁₁H₁₅Cl₂O₃PS₂
• 分子量: 361.25
• InChiKey: JAZJVWLGNLCNDD-UHFFFAOYSA-N

物化性质

• 溶解度：
  可溶于氯仿（少许）、甲醇（少许）
• 物理描述：
  Chlorthiophos is a yellow-brown liquid which tends to crystallize at less than 77F. Used as an insecticide and acaricide. (EPA, 1998)
• 颜色/状态：
  Brown liquid with crystals at low temp
• 沸点：
  150 °C at 0.001 mm Hg
• 密度：
  1.345 at 68 °F (EPA, 1998)
• 蒸汽压力：
  0.0004 mm Hg at 77 °F (EPA, 1998)
• 保留指数：
  2242

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  85.1
• 氢给体数：
  0
• 氢受体数：
  5

ADMET

代谢

动物和植物中的降解是迅速的，包括.sulfoxide和 sulfone在内的代谢物。

Degradation in animal and plant is rapid with metabolites incl the sulfoxide and sulfone.

来源:Hazardous Substances Data Bank (HSDB)

代谢

血浆和组织酶负责将有机磷化合物水解成相应的磷酸和磷onic酸。然而，氧化酶也参与一些有机磷化合物的代谢。抗胆碱酯酶剂

Plasma and tissue enzymes are responsible for hydrolysis /of organophosphorus compounds/ to the corresponding phosphoric and phosphonic acids. However, oxidative enzymes are also involved in the metabolism of some organophosphorus compounds. /Anticholinesterase agents/

来源:Hazardous Substances Data Bank (HSDB)

代谢

有机磷抗胆碱酯酶剂在体内被一组称为A-酯酶或对氧磷酶的酶水解。这些酶存在于血浆和肝脏中，能够水解大量的有机磷化合物...通过断裂磷酯键、酐键、P-F键或P-CN键。/抗胆碱酯酶剂/

The organophosphorus anticholinesterase agents are hydrolyzed in the body by a group of enzymes known as A-esterases or paraoxonases. These enzymes are found in the plasma and liver and hydrolyze a large number of organophosphorus compounds ... by cleaving the phosphoester, anhydride, P-F, or P-CN bonds. /Anticholinesterase agents/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 副作用

其他毒物 - 有机磷

Other Poison - Organophosphate

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 相互作用

一些吩噻嗪类药物可能拮抗，而另一些可能增强有机磷杀虫剂的毒性抗胆碱酯酶效果。/有机磷胆碱酯酶抑制剂/

Some phenothiazines may antagonize & some may potentiate the toxic anticholinesterase effects of ... /organophosphorus insecticides/. /Organophosphate cholinesterase inhibitors/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

在长期治疗中，肾上腺皮质激素对抗抗胆碱酯酶的抗青光眼作用（增加眼内压）。... 抗胆碱药对抗抗胆碱酯酶在自主神经和中央神经系统上的缩瞳（抗青光眼）和其他毒蕈碱作用。三环类抗抑郁药（抗胆碱能作用）对抗抗胆碱酯酶在青光眼中的抗青光眼（缩瞳）作用。... 具有抗胆碱能作用的抗组胺药对抗抗胆碱酯酶的缩瞳（抗青光眼）和中央神经系统作用。抗胆碱酯酶增强由抗组胺药引起的镇静和行为改变。抗胆碱酯酶药物在自主效应细胞上的作用，以及在某种程度上对中枢神经系统的作用，可被阿托品这种首选解毒剂所拮抗。巴比妥类药物的作用可被抗胆碱酯酶增强。... 二泛醇增强抗胆碱酯酶的效果。氟磷酸盐杀虫剂增强其他抗胆碱酯酶的效果。/抗胆碱酯酶/

In long term therapy, adrenocorticoids antagonize the antiglaucoma effects of anticholinesterases (incr ocular pressure). ... Anticholinergics antagonize the miotic (antiglaucoma) & other muscarinic effects of anticholinesterases on the autonomic & central nervous systems. Tricyclic antidepressants (anticholinergic effects) antagonize the antiglaucoma (miotic) effects of anticholinesterases in glaucoma. ... Antihistamines with anticholinergic effects antagonize the miotic (antiglaucoma) & CNS effects of anticholinesterases. Anticholinesterases potentiate tranquilizing & behavioral changes induced by antihistamines. The actions of anticholinesterase agents on autonomic effector cells, & to some extent those on CNS, are antagonized by atropine, an antidote of choice. Barbiturates are potentiated by anticholinesterases. ... Dexpanthenol potentiates the effects of anticholinesterases. Fluorophosphate insecticides potentiate the effects of other anticholinesterases. /Anticholinesterases/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

巴比妥类药物会被抗胆碱酯酶增强效果。尽管巴比妥类药物在谨慎使用的情况下可以治疗癫痫，但在处理由于抗胆碱酯酶导致的中毒时，尤其是在有机磷农药中毒的情况下，需要极度小心。毒扁豆碱是一种用作缩瞳剂的抗胆碱酯酶抑制剂，它可以增强其他类似抑制剂的效果...用于其他目的（叠加效果）或可能的协同作用。那些暴露于有机磷杀虫剂的人必须采取严格预防措施。...有机磷杀虫剂：叠加的抗胆碱酯酶效果。危险。使用抗胆碱酯酶的病人（即使是局部使用，如眼药水）应避免去最近使用过有机磷杀虫剂的地方。/抗胆碱酯酶/

BARBITURATES ARE POTENTIATED BY ANTICHOLINESTERASES. ALTHOUGH BARBITURATES MAY BE USED CAUTIOUSLY IN TREATING CONVULSIONS, EXTREME CARE IS ESSENTIAL IN HANDLING POISONINGS DUE TO ANTICHOLINESTERASES, PARTICULARLY ORGANOPHOSPHORUS PESTICIDES. ECHOTHIOPHATE, A CHOLINESTERASE INHIBITOR USED AS MIOTIC, POTENTIATES OTHER SUCH INHIBITORS ... USED FOR OTHER PURPOSES (ADDITIVE EFFECTS) OR POSSIBLY SYNERGISTIC. THOSE EXPOSED TO ORGANOPHOSPHATE INSECTICIDES MUST TAKE STRICT PRECAUTIONS. ... ORGANOPHOSPHORUS INSECTICIDES: ADDITIVE ANTICHOLINESTERASE EFFECTS. HAZARDOUS. PATIENTS ON ANTICHOLINESTERASES (EVEN TOPICAL, SUCH AS EYE DROPS) SHOULD AVOID AREAS WHERE ORGANOPHOSPHORUS INSECTICIDES ... RECENTLY ... USED. /ANTICHOLINESTERASE/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

抗胆碱酯酶（有机磷）杀虫剂对抗极化肌肉松弛剂。吩噻嗪类/和硫杂蒽类/：...可能增强有机磷杀虫剂的有毒效果。/杀虫剂，有机磷/

ANTICHOLINESTERASE (ORGANOPHOSPHORUS) INSECTICIDES ANTAGONIZE POLARIZING MUSCLE RELAXANTS. PHENOTHIAZINES /AND THIOXANTHENES/: ... MAY ENHANCE TOXIC EFFECTS OF ORGANOPHOSPHORUS INSECTICIDES. /INSECTICIDES, ORGANOPHOSPHORUS/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

大多数有机磷化合物能够通过皮肤、结膜、胃肠道和肺部被吸收。/有机磷化合物/

Most organophosphate compounds are ... absorbed from skin, conjunctiva, gastrointestinal tract, & lung. /Organophosphate compounds/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

有机磷农药的皮肤吸收率可能会受到所使用溶剂的影响。

The rate of dermal absorption /of organophosphorus pesticides/ may be ... influenced by the solvent used. /Organophosphorus pesticides/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

许多有机磷杀虫剂会通过牛奶排出体外... /有机磷杀虫剂/

Many of the organophosphorus insecticides are excreted in the milk ... /Organophosphorus insecticides/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

有机磷化合物被吸收后，大部分以水解产物的形式几乎完全通过尿液排出。/抗胆碱酯酶剂/

Following their absorption, most organophosphorus cmpd are excreted almost entirely as hydrolysis products in the urine. /Anticholinesterase agents/

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险等级：
  6.1(a)
• 海关编码：
  2930909063

制备方法与用途

类别：农药

毒性分级：剧毒

急性毒性：

• 大鼠经口 LD50：7.8 毫克/公斤
• 小鼠经口 LD50：91.4 毫克/公斤

可燃性危险特性：

• 明火条件下可燃
• 受热时释放有毒氧化磷、氯化物及氧化硫气体

储运特性：

• 应存放在通风、低温和干燥的库房内
• 与食品原料分开储存和运输

灭火剂：砂土、干粉或泡沫

文献信息

• INHIBITORS OF POLYISOPRENYLATED METHYLATED PROTEIN METHYL ESTERASE
  申请人：Lamango Nazarius Saah

  公开号：US20090253640A1

  公开（公告）日：2009-10-08

  Inhibitors of the enzyme prenylated methylated protein methyl esterase (PMPMEase), the last step in the prenylation process for many eukaryotic proteins, having the general structure R 1 -X-A-B(R 2 )-Y or R 1 -X-A(R 2 )-B-Y, where R 1 is preferably a polyisoprenyl group, X is a linking group, Y is a group that promotes affinity interactions to the active site of PMPMEase and imparts hydrolysis resistance to the inhibitor, A and B are bridge atoms, and R 2 is a characteristic-providing substituent.

  抑制酶前醇基化蛋白甲基酯酶（PMPMEase）的化合物，这是许多真核蛋白质前醇化过程的最后一步，具有一般结构R1-X-A-B（R2）-Y或R1-X-A（R2）-B-Y，其中R1最好是多异戊烯基团，X是连接基团，Y是促进与PMPMEase活性位点的亲和作用并赋予抑制剂水解抗性的基团，A和B是桥接原子，R2是提供特征的取代基。
• A method of controlling harmful insects
  申请人：NIHON BAYER AGROCHEM K.K.

  公开号：EP0564945A1

  公开（公告）日：1993-10-13

  The present invention relates to a process for the treatment of individual plants with solid shaped plant treatment agents which are introduced into the sap conduction paths of the plants, new solid shaped plant treatment agents and their production.

  本发明涉及一种用固体形状植物处理剂处理单株植物的工艺，这种处理剂被引入植物的汁液传导路径、新型固体形状植物处理剂及其生产。
• Shaped bodies which release agrochemical active substances
  申请人：——

  公开号：US20010039248A1

  公开（公告）日：2001-11-08

  The present invention relates to shaped articles which release agrochemical active compounds, are used for treatment of woody plants and are employed in a hollow preformed in the woody plant, are of a volume which fills the volume of the hollow to the extent of 10 to 95%, are of a volume which does not increase during the period of use to the extent that the preformed hollow space is filled completely, comprise a) agrochemical active compounds, b) water-insoluble thermoplastically processable polymers, c) water-soluble polymers and d) if appropriate further auxiliaries.

  本发明涉及可释放农用化学活性化合物的异形物品，这些物品用于处理木本植物，并且 用于木本植物中预先形成的中空部分、 其体积可填充中空体积的 10%至 95%、 在使用期间，其体积不会增加到完全填满预制中空空间的程度、 a) 农用化学品活性化合物，b) 不溶于水的可热塑性加工聚合物，c) 水溶性聚合物，d) 适当的其他辅助剂。
• [DE] WIRKSTOFFFREISETZENDE POLYSACCHARIDETHERESTER<br/>[EN] POLYSACCHARIDE ETHER ESTERS WHICH RELEASE ACTIVE INGREDIENTS<br/>[FR] ETHERS ESTERS DE POLYSACCHARIDE LIBERANT UN PRINCIPE ACTIF
  申请人：BAYER AKTIENGESELLSCHAFT

  公开号：WO1997017847A1

  公开（公告）日：1997-05-22

  (DE) Die vorliegende Erfindung betrifft Systeme bestehend aus Polysaccharidetherestern und agrochemischen Wirkstoffen, die gegebenenfalls übliche Zusatzstoffe enthalten und biologisch abbaubar sind.(EN) The invention relates to systems comprising polysaccharide ether esters and agrochemical active ingredients which optionally contain common additives and are biodegradable.(FR) L'invention concerne des systèmes comprenant des éthers esters de polysaccharide et des principes actifs agrochimiques, qui contiennent éventuellement des additifs classiques et sont biodégradables.

  本发明涉及由聚合半乳糖苷酯和农业用活性成分组成的系统，可选地还含有通常添加的成分，可生物降解。
• WIRKSTOFFFREISETZENDE POLYSACCHARIDETHERESTER
  申请人：BAYER AG

  公开号：EP0861024A1

  公开（公告）日：1998-09-02