甲基1059粉剂 | 8022-00-2

• 物质功能分类: 化学农药原药 - 杀虫剂 - 有机磷杀虫剂
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫代磷酸及其衍生物
• 中文名称: 甲基1059粉剂
• 中文别名: 甲基内吸磷
• 英文名称: Methyl demeton
• 英文别名: 1-dimethoxyphosphorylsulfanyl-2-ethylsulfanylethane;2-ethylsulfanylethoxy-dimethoxy-sulfanylidene-λ5-phosphane
• CAS: 8022-00-2
• 化学式: C12H30O6P2S4
• 分子量: 460.6
• InChiKey: KPNPDRFFWQBXGT-UHFFFAOYSA-N

物化性质

• 密度：
  1.1900
• 物理描述：
  Methyl demeton is an oily colorless to pale yellow liquid with an unpleasant odor. Slightly water soluble.
• 沸点：
  Decomposes (NIOSH, 2016)
• 溶解度：
  Solubility in water, g/100ml at 20 °C: 2.2
• 蒸汽压力：
  Vapor pressure, Pa at 20 °C: 0.04
• 保留指数：
  1597.7;1608.7

计算性质

• 辛醇/水分配系数(LogP)：
  5.15
• 重原子数：
  24
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  171
• 氢给体数：
  0
• 氢受体数：
  10

ADMET

毒理性

• 暴露途径

这种物质可以通过吸入、皮肤接触和摄入被身体吸收。

The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 暴露途径

吸入，皮肤吸收，吞食，皮肤和/或眼睛接触

inhalation, skin absorption, ingestion, skin and/or eye contact

来源:The National Institute for Occupational Safety and Health (NIOSH)

毒理性

• 症状

眼睛刺激，皮肤刺激；眼睛疼痛，流鼻涕（稀薄的鼻粘液排出）；恶心，头痛，头晕，呕吐

irritation eyes, skin; ache eyes, rhinorrhea (discharge of thin nasal mucus); nausea, headache, dizziness, vomiting

来源:The National Institute for Occupational Safety and Health (NIOSH)

毒理性

• 吸入症状

抽搐。眩晕。呼吸困难。恶心。瞳孔缩小，肌肉痉挛，过度流涎。出汗。昏迷。

Convulsions. Dizziness. Laboured breathing. Nausea. Pupillary constriction, muscle cramp, excessive salivation. Sweating. Unconsciousness.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 皮肤症状

可能会被吸收！请参见吸入部分。

MAY BE ABSORBED! See Inhalation.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

安全信息

• 职业暴露等级：
  C
• 职业暴露限值：
  TWA: 0.5 mg/m3 [skin]
• 危险等级：
  6.1(a)
• 包装等级：
  II
• 危险类别：
  6.1(a)

制备方法与用途

类别：农药
毒性分级：剧毒
急性毒性：口服-大鼠 LD50: 26 毫克/公斤
可燃性危险特性：明火可燃；受热分解产生有毒的氧化磷和氧化硫气体
储运特性：库房应通风、低温干燥，并与食品原料分开储运
灭火剂：砂土、干粉、泡沫
职业标准：时间加权平均容许浓度（TWA）0.5 毫克/立方米

文献信息

• Pathogen control with an oxalate (oxalic acid)
  申请人：Zaghmout M. Ousama

  公开号：US20060014641A1

  公开（公告）日：2006-01-19

  This invention relates to a method of controlling pathogens, by use of oxalate-producing enzyme, alone or in combination with toxic protein may be applied directly to the plant or produced thereon by microorganisms or by genetically modifying the plant to produce the enzyme, and to genes, microorganisms, and plants useful in that method. In one aspect this invention relates to a method of controlling insects, including lepidopterans and boll weevils, by use of oxalate-producing enzyme, alone or in combination with a crystal protein from Bacillus thuringiensis or cholesterol oxidase which may be applied directly to the plant or produced thereon by microorganisms or by genetically modifying the plant to produce the enzyme, and to genes, microorganisms, and plants useful in that method.

  本发明涉及一种控制病原体的方法，该方法通过使用产生草酸盐的酶，单独或与可直接施用到植物上或由微生物在植物上产生或通过基因修饰植物以产生该酶的有毒蛋白质相结合，并涉及该方法中有用的基因、微生物和植物。本发明的一个方面涉及一种控制昆虫（包括鳞翅目和棉铃象鼻虫）的方法，该方法通过使用产草酸盐的酶，单独或与来自苏云金芽孢杆菌（Bacillus thuringiensis）的晶体蛋白结合使用来控制昆虫。 苏云金芽孢杆菌 或胆固醇氧化酶（该酶可直接作用于植物或由微生物产生或通过基因修饰植物以产生该酶），以及该方法中有用的基因、微生物和植物。
• Methods and compositions for increasing the efficacy of biologically-active ingredients
  申请人：Windsor Brian J.

  公开号：US20060276339A1

  公开（公告）日：2006-12-07

  The invention provides methods and compositions for modulating the sensitivity of cells to cytotoxic compounds and other active agents. In accordance with the invention, compositions are provided comprising combinations of ectophosphatase inhibitors and active agents. Active agents include antibiotics, fungicides, herbicides, insecticides, chemotherapeutic agents, and plant growth regulators. By increasing the efficacy of active agents, the invention allows use of compositions with lowered concentrations of active ingredients.
• [EN] METHOD FOR MANAGING RESISTANCE TO INSECTICIDAL TRAITS AND CHEMICALS USING PHEROMONES<br/>[FR] PROCÉDÉ DE GESTION DE LA RÉSISTANCE AUX GÈNES DE RÉSISTANCE AUX INSECTES ET AUX PRODUITS CHIMIQUES INSECTICIDES UTILISANT DES PHÉROMONES
  申请人：PROVIVI INC

  公开号：WO2017112887A1

  公开（公告）日：2017-06-29

  Systems and methods for managing resistance to insecticidal traits and chemicals are provided. In one aspect, systems and methods are provided that: 1) delay the development of resistance to transgenic insecticidal crops and/or chemical insecticides (preemptive strategies), and 2) rescue one or more pests' susceptibility to transgenic insecticidal crops and/or chemical insecticides once pest resistance has developed (responsive strategies).