N-(α-cyanobenzylidene)methylamine | 21864-88-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(α-cyanobenzylidene)methylamine
• 英文别名: (methylimino)phenylacetonitrile；methylimino-phenyl-acetonitrile；α-Methylimino-phenylessigsaeurenitril；Methylimino-phenyl-acetonitril；α-Methylimino-phenylacetonitril；α-Cyanobenzylidenmethylamin；N-methylbenzenecarboximidoyl cyanide
• CAS: 21864-88-0
• 化学式: C₉H₈N₂
• 分子量: 144.176
• InChiKey: BSAIGPISPNGPDN-UHFFFAOYSA-N

物化性质

• 熔点：
  38-39 °C
• 沸点：
  94 °C(Press: 13 Torr)
• 密度：
  0.96±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  36.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(α-cyanobenzylidene)methylamine 在 氢氧化钾 作用下， 以 甲醇 、 水 为溶剂， 反应 2.0h， 以3.1 g的产率得到4,5-diphenyl-1-methyl-1H-imidazole
  参考文献：
  名称：

  Cawkill, Eric; Clark, Nigel G., Journal of the Chemical Society. Perkin transactions I, 1980, p. 244 - 248

  摘要：

  DOI：
• 作为产物：
  描述：

  N-methyl-α-phenylnitrone 在 zinc(II) iodide 、 lithium diisopropyl amide 作用下， 生成 N-(α-cyanobenzylidene)methylamine
  参考文献：
  名称：

  氰基-O-甲硅烷基羟胺作为硝酮保护基团

  摘要：

  三甲基氰硅烷到加法ñ -烷基- Ç -phenylnitrones得到氰基ö -silylhydroxylamines; 这些物质与氟化银的反应以定量收率再生了硝酮，从而提供了有用的硝酮保护基团。

  DOI：

  10.1039/c39860000789

文献信息

• [EN] COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE<br/>[FR] COMPOSÉS UTILES COMME INHIBITEURS DE LA KINASE ATR
  申请人：VERTEX PHARMA

  公开号：WO2011143426A1

  公开（公告）日：2011-11-17

  The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I wherein the variables are as defined herein.

  本发明涉及可用于作为ATR蛋白激酶抑制剂的吡嗪和吡啶化合物。本发明还涉及包含本发明化合物的药用可接受组合物；使用本发明化合物治疗各种疾病、障碍和状况的方法；制备本发明化合物的方法；制备本发明化合物的中间体；以及使用化合物进行体外应用的方法，例如研究生物和病理现象中的激酶；研究由这类激酶介导的细胞内信号转导途径；以及比较评估新的激酶抑制剂。本发明的化合物具有式I，其中变量如所定义。
• RuO4-mediated oxidation of secondary amines: Part 1. Are hydroxylamines main intermediates?
  作者：Cristina Florea、Horia Petride

  DOI：10.2298/jsc151215029f

  日期：——

  The RuO4-catalyzed oxidation of secondary amines Bn-NH-CH2R (1a-b; R=H, Me) gave mainly amides, but minute amounts of nitrones PhCH=N(O)-CH2R (9a-b) and traces of Bn-N(OH)-CH2R (R=H, 4a) were also detected. In the presence of cyanide, up to 22 reaction products were identified, but mainly ?-aminonitriles. Comparison of the oxidation products of 1a-b with those of 4a-b, 9a-b, and Bn-N(O)=CHR (10a-b) showed that 4a-b cannot be main reaction intermediates formed from 1a-b.

  RuO4 催化氧化仲胺 Bn-NH-CH2R (1a-b; R=H, Me) 主要生成酰胺，但也有微量的亚硝基 PhCH=N(O)-CH2R (9a-b) 和微量的 Bn-N(OH)-CH2R (R=H, Me) 还检测到微量的 Bn-N（OH）-CH2R（R=H，4a）。在存在 氰化物存在时，可鉴定出多达 22 种反应产物，但主要是 ......氨基腈。将 1a-b 的氧化产物与 4a-b、9a-b 和 Bn-N(O)=CHR (10a-b) 的氧化产物进行比较，发现 4a-b 不可能是由 1a-b 生成的主要反应中间产物。 1a-b 形成的主要反应中间产物。
• Lithographic printing plate precursor and lithographic printing method
  申请人：Fuji Photo Film Co., Ltd.

  公开号：EP1754614A1

  公开（公告）日：2007-02-21

  The invention is directed to a lithographic printing plate precursor comprising a support and an image-recording layer, wherein the image-recording layer comprises (1) an infrared absorber and (2) a photochromic compound. The invention is also directed to a method of plate making and a lithographic printing method, each method using the lithographic printing plate precursor.

  本发明涉及一种平版印刷板前体，包括一个支撑物和一个图像记录层，其中图像记录层包括(1)红外线吸收剂和(2)光致变色化合物。本发明还涉及一种制版方法和一种平版印刷方法，每种方法都使用平版印刷板前体。
• INKJET PRINTER AND IMAGE-FORMING METHOD
  申请人：Konica Minolta Medical & Graphic, Inc.

  公开号：EP2030792A1

  公开（公告）日：2009-03-04

  Disclosed is an ink-jet printer which uses an actinic ray-curable ink-jet ink containing a cationic-polymerizable compound and is capable of performing stable image recording with inhibiting formation of precipitates within the printer and an image forming method by use thereof. The ink-jet printer ejecting an ink comprising a cationic-polymerizable compound onto a recording medium, characterized in that the ink-jet printer comprises ink-contact members which constitute an ink tank retaining the ink and an ink supply passage of from the ink tank to a recording head ejecting the ink and the ink-contact members are each comprised of a material which does substantially not undergo electron transfer with the ink.

  本发明公开了一种喷墨打印机，该打印机使用含有阳离子可聚合化合物的放 射线固化喷墨墨水，能够在抑制打印机内沉淀物形成的同时进行稳定的图像记录， 并公开了使用该打印机的图像形成方法。将含有阳离子可聚合化合物的墨水喷射到记录介质上的喷墨打印机，其特征在于，喷墨打印机包括墨水接触部件，这些部件构成一个墨水槽，用于保存墨水，以及一个从墨水槽到喷射墨水的记录头的供墨通道，墨水接触部件均由基本上不与墨水发生电子转移的材料构成。
• POLYCARBONATE RESIN AND COATING SOLUTION CONTAINING SAME, AND MOLDED ARTICLE PRODUCED BY MOLDING SAID COATING SOLUTION
  申请人：Idemitsu Kosan Co., Ltd

  公开号：EP2746314A1

  公开（公告）日：2014-06-25

  A molded article produced by molding a coating solution that contains a polycarbonate resin represented by the following formula (1) has excellent transparency, good water repellency and oil repellency, a lower friction coefficient and excellent surface lubricity, having a capability of improving abrasion resistance. In the formula (1), Rf represents a perfluoroalkyl group having 5 or more carbon atoms and 11 or more fluorine atoms or a perfluoroalkyl group having a specific structure; and W represents a divalent group including therein a specific structural unit.

  通过模塑含有下式（1）表示的聚碳酸酯树脂的涂层溶液而生产的模塑制品具有优异的透明度、良好的防水性和防油性、较低的摩擦系数和优异的表面润滑性，并具有改善耐磨性的能力。在式 (1) 中，Rf 代表具有 5 个或更多碳原子和 11 个或更多氟原子的全氟烷基或具有特定结构的全氟烷基；W 代表其中包括特定结构单元的二价基团。