2-allyl-4-(4-chlorobenzyl)phthalazin-1(2H)-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-allyl-4-(4-chlorobenzyl)phthalazin-1(2H)-one
• 英文别名: 4-(4-chlorobenzyl)-2-allylphthalazin-1(2H)-one；4-[(4-chlorophenyl)methyl]-2-prop-2-enylphthalazin-1-one
• 化学式: C₁₈H₁₅ClN₂O
• 分子量: 310.783
• InChiKey: OHEWOPKEAKDVRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  32.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  对氯苯乙酸 在 sodium acetate 、 potassium carbonate 、 一水合肼 作用下， 以 甲苯 、 乙腈 为溶剂， 反应 25.0h， 生成 2-allyl-4-(4-chlorobenzyl)phthalazin-1(2H)-one
  参考文献：
  名称：

  作为抗真菌剂的取代的 Phthalazin-1(2H)-ones 的合成、生物评价和结构研究

  摘要：

  合成了 25 种多取代的酞嗪酮衍生物，并测试了它们对一组致病性和临床上重要的酵母菌和丝状真菌的抗真菌活性。其中，化合物 4-(4-chlorobenzyl)-2-methylphthalazin-1(2H)-one (5) 对皮肤癣菌和新型隐球菌的标准化菌株以及一些临床分离株表现出显着的抗真菌活性。对化合物 5 进行的物理化学研究揭示了其构象和电子特性，为我们未来设计新型相关抗真菌类似物提供了有用的数据。

  DOI：

  10.3390/molecules18033479

文献信息

• Anti-HIV activity of stilbene-related heterocyclic compounds
  作者：Luis M. Bedoya、Esther del Olmo、Rocío Sancho、Bianca Barboza、Manuela Beltrán、Ana E. García-Cadenas、Sonsoles Sánchez-Palomino、José L. López-Pérez、Eduardo Muñoz、Arturo San Feliciano、José Alcamí

  DOI：10.1016/j.bmcl.2006.04.087

  日期：2006.8

  Viral transcription has not been routinely targeted in the development of new antiviral drugs. This crucial step of the viral cycle depends on the concerted action of cellular and viral proteins such as NF-kappa B and Tat. In the present study, stilbene-related heterocyclic compounds including benzalphthalide, phthalazinone, imidazoindole and pyrimidoisoindole derivatives are tested for their anti-HIV activity. Original assays based on recombinant viruses were used to evaluate HIV replication inhibition and stably transfected cell lines were used to evaluate inhibition of Tat and NF-kappa B proteins. Some of the stilbene-related heterocyclic compounds analysed displayed anti-HIV activity through interference with NF-kappa B and Tat function. Moreover, compounds inhibiting both targets displayed a stronger activity on viral replication. (c) 2006 Elsevier Ltd. All rights reserved.
• Vasorelaxant activity of phthalazinones and related compounds
  作者：Esther del Olmo、Bianca Barboza、Ma Inés Ybarra、José Luis López-Pérez、Rosalía Carrón、Ma Angeles Sevilla、Cinthia Boselli、Arturo San Feliciano

  DOI：10.1016/j.bmcl.2006.02.003

  日期：2006.5

  Several series of dihydrostilbenamide, imidazo[2,1-a]isoindole, pyrimido[2,1-a]isoindole and phthalazinone derivatives were obtained and their vasorelaxant activity was measured on isolated rat aorta rings pre-contracted with phenylephrine (10(-5) M). Some phthalazinones attained, practically, the total relaxation of the organ at micromolar concentrations. For the most potent compound 9h (EC50 = 0.43 mu M) the affinities for alpha(1A), alpha(1B) and alpha(1D) adrenergic sub-receptors were determined. (C) 2006 Elsevier Ltd. All rights reserved.
• Synthesis, Bioevaluation and Structural Study of Substituted Phthalazin-1(2H)-ones Acting as Antifungal Agents
  作者：Marcos Derita、Esther del Olmo、Bianca Barboza、Ana García-Cadenas、José López-Pérez、Sebastián Andújar、Daniel Enriz、Susana Zacchino、Arturo San Feliciano

  DOI：10.3390/molecules18033479

  日期：——

  important yeasts and filamentous fungi. Among them, the compound 4-(4-chlorobenzyl)-2-methylphthalazin-1(2H)-one (5) exhibited a remarkable antifungal activity against standardised strains of dermatophytes and Cryptococcus neoformans, as well as against some clinical isolates. A physicochemical study performed on compound 5 revealed its conformational and electronic characteristics, providing us with useful

  合成了 25 种多取代的酞嗪酮衍生物，并测试了它们对一组致病性和临床上重要的酵母菌和丝状真菌的抗真菌活性。其中，化合物 4-(4-chlorobenzyl)-2-methylphthalazin-1(2H)-one (5) 对皮肤癣菌和新型隐球菌的标准化菌株以及一些临床分离株表现出显着的抗真菌活性。对化合物 5 进行的物理化学研究揭示了其构象和电子特性，为我们未来设计新型相关抗真菌类似物提供了有用的数据。