N-methyl-N-(2-(methylthio)phenyl)acetamide | 91799-47-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-methyl-N-(2-(methylthio)phenyl)acetamide
• 英文别名: N-methyl-N-(2-methylsulfanylphenyl)acetamide
• CAS: 91799-47-2
• 化学式: C₁₀H₁₃NOS
• 分子量: 195.285
• InChiKey: VHEKQQHDBGJKCU-UHFFFAOYSA-N

物化性质

• 沸点：
  316.2±25.0 °C(Predicted)
• 密度：
  1.12±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  45.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-methyl-N-(2-(methylthio)phenyl)acetamide 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 24.0h， 以60%的产率得到N-methyl-2-(methylthio)aniline
  参考文献：
  名称：

  碘促进亚甲基二甲基苯并噻唑的开环甲基化

  摘要：

  在碱的存在下，使用亚硫酸二甲酯作为甲基化试剂，已经开发了苯并噻唑的卤素键促进的开环甲基化。这种方法代表了N-甲基-N-（邻-甲硫基）苯基酰胺的一种简单有效的合成方法，其特点是通过容易制备的苯并噻唑的分解，在一个反应​​中直接构建N-Me和S-Me键。 。

  DOI：

  10.1039/d0cc08096a
• 作为产物：
  描述：

  3-甲基-2(3H)-苯并噻唑硫酮 在 氢氧化钾 作用下， 生成 N-methyl-N-(2-(methylthio)phenyl)acetamide
  参考文献：
  名称：

  Kiprianow; Pasenko, Zhurnal Obshchei Khimii, 1949, vol. 19, p. 1521

  摘要：

  DOI：

文献信息

• The copper-catalyzed aerobic oxidative amidation of tertiary amines
  作者：Hui-Cheng Cheng、Wen-Jun Hou、Zeng-Wen Li、Ming-Yu Liu、Bing-Tao Guan

  DOI：10.1039/c5cc07454a

  日期：——

  A general and efficient method for the tertiary amide synthesis has been developed via copper-catalyzed aerobic oxidative amidation of tertiary amines. Due to the use of O2 oxidant, various functional...

  通过铜催化的叔胺的好氧氧化酰胺化反应，已经开发出一种通用而有效的叔酰胺合成方法。由于使用了O2氧化剂，各种功能...
• Competitive Reaction Pathways for <i>o</i>-Anilide Aryl Radicals: 1,5- or 1,6-Hydrogen Transfer versus Nucleophilic Coupling Reactions. A Novel Rearrangement to Afford an Amidyl Radical
  作者：Valentina Rey、Adriana B. Pierini、Alicia B. Peñéñory

  DOI：10.1021/jo801892c

  日期：2009.2.6

  Together with this last rearranged product, the ipso substitution derivative was also observed. Similar results were obtained in the PET reactions of 4d (R = t-Bu) with anions 2 and 3 under entrainment conditions with the enolate anion from cyclohexenone (5) or the tert-butoxide anion (6). From this novel rearrangement, and only under reductive conditions by PET reaction with anion 5, iodide 4d (R

  的光致反应Ô -iodoanilides（ø -IC 6 ħ 4 N（Me）的COR，4A - d）与亲核试剂硫如硫脲阴离子（1，- SCNH（NH 2）），硫代乙酸酯阴离子（2，MeCOS - ），和硫化物阴离子（3，S 2-）遵循不同的反应通道，通过自由基亲核取代产生硫化物，或通过氢原子转移途径产生脱卤产物。在从1到碘化物4的初始光致电子转移（PET）之后，o产生-酰胺基芳基12。这些芳基基团12根据α-羰基部分的结构提供替代的反应途径：（a）12b（R ＝ Me）加成1以通过在照射后用MeI淬灭硫醇盐阴离子中间体而得到甲硫基取代的化合物；（b）12c（R ＝ -CH 2 Ph）在1，5-氢转移之后得到稳定的α-羰基自由基（17）；（c）12d（R = t -Bu）进行1,6-氢转移，然后进行1,4-芳基迁移以提供一个yl基（20），该基团被还原为N-苄基-N，2-二甲基丙酰胺（10）
• ADHESIVE COMPOSITION FOR OPTICAL FILTER, OPTICAL FILTER AND DISPLAY DEVICE
  申请人：Hiwatashi Yuka

  公开号：US20090116132A1

  公开（公告）日：2009-05-07

  An optical filter including an adhesive layer attaining, in a single layer, both adhesiveness and desired optical filter function and hardly undergoing the change in spectral characteristic attributable to deterioration of a light absorbing agent, even after long-time use, particularly at high temperature under high humidity. The optical filter includes: (A) an acrylic copolymer containing (meth)acrylate having a hydroxyl group as a constituent, not containing a monomer having a carboxyl group and a monomer having an amide group as constituents, and substantially not containing a carboxyl group residue; (B) an isocyanate compound; and (C) one or more light absorbing agents each having light absorption in a predetermined wavelength range.
• TOPOISOMERASE INHIBITORS
  申请人：LaVoie Edmond J.

  公开号：US20120237531A1

  公开（公告）日：2012-09-20

  The invention provides compounds of formula I: (I) wherein A, B, W, Y, Z, R 1 , R 3 and R 4 have any of the meanings defined in the specification and their salts as well as additional compounds and their salts. The invention also provides pharmaceutical compositions comprising a compound of the invention, processes for preparing compounds of the invention, intermediates useful for preparing compounds of the invention, and therapeutic methods for treating cancer, a bacterial infection or a fungal infection using compounds of the invention.
• US9321781B2
  申请人：——

  公开号：US9321781B2

  公开（公告）日：2016-04-26