N,N'-diphenylmethylenediamine | 622-14-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N'-diphenylmethylenediamine
• 英文别名: N,N'-bisphenylmethanediamine；N,N'-diphenylmethanediamine；N,N-methylene diphenylamine；N,N'-diphenylaminomethane；N-anilinomethylaniline；dianilinomethane
• CAS: 622-14-0
• 化学式: C₁₃H₁₄N₂
• 分子量: 198.268
• InChiKey: OHQOKJPHNPUMLN-UHFFFAOYSA-N

物化性质

• 熔点：
  64-65 °C
• 沸点：
  401.2±28.0 °C(Predicted)
• 密度：
  1.147±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N'-diphenylmethylenediamine 在 potassium permanganate 、 硫酸 作用下， 生成 亚硝基苯
  参考文献：
  名称：

  Bamberger; Tschirner, Chemische Berichte, 1899, vol. 32, p. 342

  摘要：

  DOI：
• 作为产物：
  描述：

  聚合甲醛 、 N-苯基甲酰胺 在 乙醇 作用下， 生成 N,N'-diphenylmethylenediamine
  参考文献：
  名称：

  Eberhardt; Welter, Chemische Berichte, 1894, vol. 27, p. 1806

  摘要：

  DOI：

文献信息

• Npy antagonists, preparation and uses
  申请人：Botez Iuliana

  公开号：US20090233910A1

  公开（公告）日：2009-09-17

  The present invention concerns novel compounds, their preparation and their uses, therapeutic uses in particular. More specifically it concerns derivative compounds having at least two aromatic cycles, their preparation and their uses, in particular in the area of human or animal health. These compounds have an affinity for the biological receptors of neuropeptide Y, NPY, present in the central and peripheral nervous systems. The compounds of the invention are preferably NPY antagonists, and more particularly antagonists of sub-type NPY Y1, and can therefore be used for the therapeutic or prophylactic treatment of any disorder involving NPY. The present invention also concerns pharmaceutical compositions containing said compounds, their preparation and their uses, as well as treatment methods using said compounds.

  本发明涉及新颖化合物，它们的制备和用途，特别是在治疗方面的用途。更具体地说，它涉及至少具有两个芳香环的衍生化合物，它们的制备和用途，特别是在人类或动物健康领域。这些化合物对存在于中枢和外周神经系统中的神经肽Y（NPY）的生物受体具有亲和力。本发明的化合物优选为NPY拮抗剂，更具体地说是NPY Y1亚型的拮抗剂，因此可用于治疗或预防涉及NPY的任何疾病。本发明还涉及含有所述化合物的药物组合物，其制备和用途，以及使用所述化合物的治疗方法。
• Bis(aniline) compounds containing multiple substituents with carbon-carbon triple-bonded groups
  申请人：Government of the United States, as represented by the Secretary of the Air Force

  公开号：US10988437B1

  公开（公告）日：2021-04-27

  The invention relates to bis(aniline) compounds containing multiple arylethynyl, alkylethynyl, ethynyl groups or their combinations, processes of making such compounds and materials comprising such compounds. Such, bis(aniline) compounds preferably comprise multiple phenylethynyl (PE) groups, i.e. 2-4 PE moieties. Such compounds are useful monomers for the preparation of polyimides, polyamides and poly(amide-imides) whose post-fabrication crosslinking chemistry (i.e. reaction temperature) can be controlled by the number of PE per repeat unit as well as finding utility in thermosetting matrix resins, 3D printable resins, and as high-carbon-content precursors to carbon-carbon composites.

  本发明涉及包含多个芳基乙炔基、烷基乙炔基、乙炔基团或其组合的二(苯胺)化合物，制造此类化合物的过程以及包含此类化合物的材料。这样的二(苯胺)化合物优选包含多个苯乙炔基(PE)团，即2-4个PE基团。这类化合物是有用的单体，用于制备聚酰亚胺、聚酰胺和聚(酰胺-亚胺)，其制品后的交联化学（即反应温度）可以通过每个重复单元中的PE数量来控制，并且还用于热固性基体树脂、3D打印树脂，以及作为高碳含量碳-碳复合材料的预聚物。
• METHOD FOR PRODUCING ISOCYANATES
  申请人：Knoesche Carsten

  公开号：US20090281350A1

  公开（公告）日：2009-11-12

  The invention provides a process for preparing isocyanates by reacting amines with phosgene, wherein the amine or a mixture of amine and a solvent is mixed in the form of an aerosol with gaseous phosgene and the amine is subsequently reacted with phosgene.

  该发明提供了一种通过将胺与光气反应来制备异氰酸酯的方法，其中胺或胺和溶剂的混合物以气溶胶形式与气态光气混合，然后胺与光气反应。
• INHIBITION OF P38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS
  申请人：Dumas Jacques

  公开号：US20120046290A1

  公开（公告）日：2012-02-23

  This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases, other than cancer and proteolytic enzyme mediated diseases, other than cancer, and pharmaceutical compositions for use in such therapy.

  本发明涉及一组芳香脲在治疗细胞因子介导的疾病（除癌症外）和蛋白水解酶介导的疾病（除癌症外）中的用途，以及用于此类治疗的药物组合物。
• Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas
  申请人：Miller Scott

  公开号：US20080269265A1

  公开（公告）日：2008-10-30

  This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.

  这项发明涉及使用一组芳基脲类化合物治疗raf介导的疾病，以及用于该疗法的药物组合物。