dicholesteryl phthalate | 24951-79-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: dicholesteryl phthalate
• 英文别名: bis(3β-cholest-5-en-3-yl) benzene-1,2-dicarboxylate；Bis-(cholesten-(5)-yl-(3β))-phthalat；Dicholesterylphthalat；cholesteryl 3-phthalate；bis[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] benzene-1,2-dicarboxylate
• CAS: 24951-79-9
• 化学式: C₆₂H₉₄O₄
• 分子量: 903.426
• InChiKey: VZHRNOZZUUXMGO-YJHYSYSZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  19.6
• 重原子数：
  66
• 可旋转键数：
  16
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  dicholesteryl phthalate 在 溴 、 溶剂黄146 作用下， 以 乙醚 为溶剂， 生成 Bis-(5α,6β-dibrom-cholestanyl-(3β))-phthalat
  参考文献：
  名称：

  Maas,S.P.J. et al., Bulletin des Societes Chimiques Belges, 1963, vol. 72, p. 239 - 254

  摘要：

  DOI：
• 作为产物：
  描述：

  苯酐 、 cholesterol 生成 dicholesteryl phthalate
  参考文献：
  名称：

  硫修饰核苷、核苷酸和寡核苷酸的合成、化学修饰和生物应用的最新进展

  摘要：

  介绍 ....... 。………………………………………… …………………………………… …………………… …………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………… .. .. .. .. .. .. 29 1. 杂环基的修改 ..................................... ...................................... 29 1. 含有核苷、核苷酸的硫代碱基 ..................... ………………………………………………………………………………………………………………………………………………………… ................. 29 2. 含寡核苷酸的硫基碱基、光化学探针和工具

  DOI：

  10.1080/00304940209355745

文献信息

• CARBOXYLIC ACID-TYPE LIPID, AND LIPID PARTICLE AND LIPID MEMBRANE EACH COMPRISING CARBOXYLIC ACID-TYPE LIPID
  申请人：Toray Industries, Inc.

  公开号：US20210387943A1

  公开（公告）日：2021-12-16

  A carboxylic acid-type lipid can accelerate adhesion or aggregation of platelets even if the carboxylic acid-type lipid does not carry a protein involved in adhesion or aggregation of platelets or a peptide corresponding to an active site of the protein; a lipid particle and a lipid membrane each include the carboxylic acid-type lipid; and a platelet aggregation accelerating agent, a platelet adhesion accelerating agent, a hemostatic agent and a platelet substitute each include the carboxylic acid-type lipid, the lipid particle or the lipid membrane. A carboxylic acid-type lipid is selected from carboxylic acid-type lipids represented by formulas (I) to (VI), a lipid particle includes the carboxylic acid-type lipid, a lipid membrane includes the carboxylic acid-type lipid, and a platelet aggregation accelerating agent, a platelet adhesion accelerating agent, a hemostatic agent and a platelet substitute each include the carboxylic acid-type lipid, the lipid particle or the lipid membrane.

  一种羧酸型脂质即使不携带与血小板粘附或聚集有关的蛋白质或相应的蛋白质活性位点对血小板的粘附或聚集也能加速，脂质颗粒和脂质膜均包括该羧酸型脂质；血小板聚集加速剂、血小板粘附加速剂、止血剂和血小板替代物均包括该羧酸型脂质、脂质颗粒或脂质膜。所述羧酸型脂质选自公式（I）到（VI）所表示的羧酸型脂质，脂质颗粒包括该羧酸型脂质，脂质膜包括该羧酸型脂质，血小板聚集加速剂、血小板粘附加速剂、止血剂和血小板替代物均包括该羧酸型脂质、脂质颗粒或脂质膜。
• New non-phospholipid lipid vesicles (npLV) and their use in cosmetic, therapeutic and prophylactic applications
  申请人：Wallach, Donald F. H.

  公开号：EP1304103A1

  公开（公告）日：2003-04-23

  The present invention concerns new lipid vesicles wherein all said lipids are non phospholipid lipids, methods of preparation thereof as well as their use as vehicle particularly in therapeutic applications such as prevention of AIDS.

  本发明涉及所有所述脂质均为非磷脂类脂质的新型脂质囊泡及其制备方法，以及它们作为载体的用途，特别是在预防艾滋病等治疗应用中的用途。
• IMMUNOLIPOSOME INDUCING APOPTOSIS INTO CELL EXPRESSING DEATH DOMAIN-CONTAINING RECEPTOR
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP2177230A1

  公开（公告）日：2010-04-21

  The present invention relates to an immunoliposome preparation having a therapeutic effect on cancer, autoimmune disease, or inflammatory disease. Specifically, the present invention relates to an immunoliposome comprising, as a constituent, an antibody capable of inducing the apoptosis of cells expressing a death domain-containing receptor.

  本发明涉及一种对癌症、自身免疫性疾病或炎症性疾病具有治疗作用的免疫脂质体制剂。具体而言，本发明涉及一种免疫脂质体，其成分包括一种能够诱导表达含死亡结构域受体的细胞凋亡的抗体。
• ANTIBODY MODIFIED WITH HYDROPHOBIC MOLECULE
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP2184355A1

  公开（公告）日：2010-05-12

  The present invention relates to an immunoliposome preparation or a hydrophobic molecule-modified antibody having a therapeutic effect on cancer, autoimmune disease, or inflammatory disease. Specifically, the present invention relates to an immunoliposome or a hydrophobic molecule-modified antibody comprising, as a constituent, an antibody capable of inducing the apoptosis of cells expressing a death domain-containing receptor.

  本发明涉及一种对癌症、自身免疫性疾病或炎症性疾病具有治疗作用的免疫脂质体制剂或疏水分子修饰的抗体。具体而言，本发明涉及一种免疫脂质体或疏水分子修饰的抗体，其成分包括一种能够诱导表达含死亡结构域受体的细胞凋亡的抗体。
• AMPHIPHILIC COMPOUND, AND RESIN COMPOSITION FOR MEDICAL USE AND DRUG ADDITIVE EACH USING SAME
  申请人：Nippon Shokubai Co., Ltd.

  公开号：EP3950735A1

  公开（公告）日：2022-02-09

  Provided is means capable of reducing the adsorptivity to plastics while suppressing a decrease in intracellular uptake efficiency in an amphiphilic compound that can be applied to long-term blood-retaining liposomes or the like as a drug carrier. The above problem can be solved by an amphiphilic compound comprising a moiety (I) including a constitutional unit (A) derived from a monomer (a) having two or more hydroxyl groups and having 2 to 10 carbon atoms constituting the side chain among the carbon atoms of the constitutional unit, and a hydrocarbon group having 8 or more carbon atoms.

  本发明提供了一种方法，能够降低两亲化合物对塑料的吸附性，同时抑制细胞内吸收效率的降低，这种两亲化合物可用作长期留血脂质体或类似药物载体。 上述问题可以通过一种两亲化合物来解决，该化合物包含一个分子（I），该分子（I）包括一个由单体（a）衍生的构型单元（A），该单体（a）具有两个或两个以上羟基，在构型单元的碳原子中具有 2 至 10 个碳原子构成侧链，以及一个具有 8 个或 8 个以上碳原子的烃基。