cholesteryl iso-amyl ether | 74996-30-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: cholesteryl iso-amyl ether
• 英文别名: O-isopentyl-cholesterol；O-Isopentyl-cholesterin；3β-Isopentyloxy-cholesten-(5)；Isopentyl-cholesteryl-aether；(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-3-(3-methylbutoxy)-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene
• CAS: 74996-30-8
• 化学式: C₃₂H₅₆O
• 分子量: 456.796
• InChiKey: ANAJYEZUWQRKRT-RWFZIKKDSA-N

物化性质

• 沸点：
  516.6±29.0 °C(Predicted)
• 密度：
  0.94±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  10.8
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 储存条件：
  -20°C

制备方法与用途

胆固醇异戊醚是一种生物化学试剂，可用于生物材料或有机化合物的研究，在生命科学领域具有重要作用。

反应信息

• 作为产物：
  描述：

  异戊醇 、 cholesterol 在 Fuller's Earth 、 xylene 作用下， 生成 cholesteryl iso-amyl ether
  参考文献：
  名称：

  Relationship between Body Mass Index and the Use of Healthcare Services in Australia

  摘要：

  AbstractObjective: To examine the relationship between body mass index (BMI) and the use of medical and preventive health services.Research Methods and Procedures: This study involved secondary analysis of weighted data from the Australian 1995 National Health Survey. The study was a population survey designed to obtain national benchmark information about a range of health‐related issues. Data were available from 17,033 men and 17,174 women, ≥20 years or age. BMI, based on self‐reported weight and height, was analyzed in relation to the use of medical services and preventive health services.Results: A positive relationship was found between BMI and medical service use, such as medication use, visits to hospital accident and emergency departments (for women only); doctor visits, visits to a hospital outpatient clinics; and visits to other health professionals (for women only). A negative relationship was found in women between BMI and preventive health services. Underweight women were found to be significantly less likely to have Papanicolaou smear tests, breast examinations, and mammograms.Discussion: This research shows that people who fall outside the healthy weight range are more likely to use a range of medical services. Given that the BMI of industrialized populations appears to be increasing, this has important ramifications for health service planning and reinforces the need for obesity prevention strategies at a population level.

  DOI：

  10.1038/oby.2002.71

文献信息

• The synthesis of cholesteryl alkyl ethers
  作者：G. Halperin、S. Gatt

  DOI：10.1016/0039-128x(80)90109-9

  日期：1980.1

  Seventeen cholesteryl alkyl ethers were synthesized through alcoholysis of cholesterol p-toluenesulfonate. This method was found superior to the etherification of sodium or potassium cholesterylate with alkyl halides or methanesulfonates, especially for the preparation of long-chain unsaturated aklyl ethers of [7(m)-3H]cholesterol of high specific activity.

  通过胆固醇对甲苯磺酸的醇解合成了十七种胆固醇烷基醚。发现该方法优于胆甾醇钠或胆甾醇钾与烷基卤化物或甲磺酸盐的醚化，特别是用于制备高比活性的 [7(m)-3H] 胆固醇的长链不饱和烷基醚。
• LIPID-BASED PLATINUM COMPOUNDS AND NANOPARTICLES
  申请人：INVICTUS ONCOLOGY PVT. LTD.

  公开号：US20160145284A1

  公开（公告）日：2016-05-26

  The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to platinum based compounds comprising platinum moiety, linker moiety and lipid moiety and corresponding nanoparticles thereof. The disclosure further relates to synthesis of said platinum based compounds, nanoparticles and compositions comprising said platinum based compounds/nanoparticles. The disclosure also relates to methods of managing cancer by employing aforesaid carbene compounds, platinum based compounds, nanoparticles and compositions thereof.

  本公开涉及纳米技术和癌症治疗领域。特别地，本公开涉及包含铂基团、链接基团和脂质基团的铂基化合物及其相应的纳米粒子。本公开还涉及所述铂基化合物、纳米粒子的合成和包含所述铂基化合物/纳米粒子的组合物。本公开还涉及使用上述卡宾化合物、铂基化合物、纳米粒子和其组合物治疗癌症的方法。
• Relationship between Body Mass Index and the Use of Healthcare Services in Australia
  作者：Daniel D. Reidpath、David Crawford、Linda Tilgner、Carl Gibbons

  DOI：10.1038/oby.2002.71

  日期：2002.6

  AbstractObjective: To examine the relationship between body mass index (BMI) and the use of medical and preventive health services.Research Methods and Procedures: This study involved secondary analysis of weighted data from the Australian 1995 National Health Survey. The study was a population survey designed to obtain national benchmark information about a range of health‐related issues. Data were available from 17,033 men and 17,174 women, ≥20 years or age. BMI, based on self‐reported weight and height, was analyzed in relation to the use of medical services and preventive health services.Results: A positive relationship was found between BMI and medical service use, such as medication use, visits to hospital accident and emergency departments (for women only); doctor visits, visits to a hospital outpatient clinics; and visits to other health professionals (for women only). A negative relationship was found in women between BMI and preventive health services. Underweight women were found to be significantly less likely to have Papanicolaou smear tests, breast examinations, and mammograms.Discussion: This research shows that people who fall outside the healthy weight range are more likely to use a range of medical services. Given that the BMI of industrialized populations appears to be increasing, this has important ramifications for health service planning and reinforces the need for obesity prevention strategies at a population level.