N,N-Dimethylformamide Hydrochloride - CAS号 3397-76-0

物化性质

熔点：

38-40 °C
沸点：

55-56 °C (12 mmHg)
稳定性/保质期：

在常温常压下稳定，但对水敏感。应避免与不相容材料、热源、火源、湿空气和水接触。它可能与潮湿空气、水、还原剂、酸、碱金属、卤化剂、硝酸盐、金属氧化物及氯代甲酸酯发生反应。

计算性质

辛醇/水分配系数(LogP)：

-3.55
重原子数：

6
可旋转键数：

0
环数：

0.0
sp3杂化的碳原子比例：

0.666
拓扑面积：

23.2
氢给体数：

1
氢受体数：

2

安全信息

危险品标志：

T
安全说明：

S26,S45,S53
危险类别码：

R20/21,R36/37/38,R61
储存条件：

应密封储存于阴凉、干燥的库房，并远离火源。

SDS

SDS：c1eee9bbce0967d6d2ca2e33d0a16e53

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Name:	Dimethylformamide Hydrogen Chloride Complex DMF-HCl 2:1 Mol. Ratio Material Safety Data Sheet
Synonym:	None known
CAS:	3397-76-0

Section 1 - Chemical Product MSDS Name:Dimethylformamide Hydrogen Chloride Complex DMF-HCl 2:1 Mol. Ratio Material Safety Data Sheet
Synonym:None known

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
3397-76-0	Dimethylformamide Hydrogen Chloride	ca 100	unlisted

Hazard Symbols: XI
Risk Phrases: 36/37/38

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.Hygroscopic (absorbs moisture from the air).Moisture sensitive.The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
Causes eye irritation. May cause chemical conjunctivitis.
Skin:
Causes skin irritation.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated.
Inhalation:
Causes respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Can produce delayed pulmonary edema.
Chronic:
Effects may be delayed.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Containers may explode when heated.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Do NOT get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Provide ventilation. Do not get water inside containers.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Do not allow contact with water. Keep from contact with moist air and steam.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 3397-76-0: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Liquid
Color: clear slightly yellow
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 55.0 - 56.0 deg C @ 12.00mmHg
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: 150 deg C ( 302.00 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: 150 deg C
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C3H8ONCl
Molecular Weight: 109.55

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials, moisture, excess heat, strong oxidants, exposure to moist air or water.
Incompatibilities with Other Materials:
Moisture.
Hazardous Decomposition Products:
Hydrogen chloride, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 3397-76-0 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
Dimethylformamide Hydrogen Chloride - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 7/8 Keep container tightly closed and dry.
S 24/25 Avoid contact with skin and eyes.
S 28A After contact with skin, wash immediately with
plenty of water.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 3397-76-0: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 3397-76-0 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 3397-76-0 is not listed on the TSCA inventory.
It is for research and development use only.

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

作为反应物：

描述：

胆固醇、 N,N-Dimethylformamide Hydrochloride 反应 2.0h，以48%的产率得到胆甾烯基甲酸酯

参考文献：

名称：

DMF·HCl as a versatile and straightforwardN- andO-formylating agent

摘要：

Inspired by the serendipitous isolation of N-formylpiperazines when we attempted the synthesis of a series of piperazines, we have developed a straightforward methodology for the N- and O- formylation of secondary cyclic amines, anilines and steroids, respectively. Such approach is based on the hitherto non-reported use of DMF center dot HCl complex, as a versatile and easily-available formylating system that can be stored without apparent loss of activity.

DOI：

10.1080/00397911.2020.1844901
作为产物：

描述：

N,N-二甲基甲酰胺在盐酸作用下，以水为溶剂，反应 3.0h，生成 N,N-Dimethylformamide Hydrochloride

参考文献：

名称：

[HDMF]Cl-based DES as highly efficient extractants and catalysts for oxidative desulfurization of model oil

摘要：

[HDMF]Cl/XMCln表现出高脱硫活性。同时，使用N，N-二甲基甲酰胺可以节省很多DES，保护环境。

DOI：

10.1039/c8ra10554e
作为试剂：

描述：

2-环己烯-1-酮在 N,N-Dimethylformamide Hydrochloride 、间氯过氧苯甲酸作用下，反应 0.5h，以51%的产率得到2-chlorocyclohex-2-en-1-one

参考文献：

名称：

EP3889156

摘要：

公开号：

点击查看最新优质反应信息

文献信息

Halonitriles, their preparation and use to make halopyridines

申请人：The Dow Chemical Company

公开号：US04562009A1

公开（公告）日：1985-12-31

Novel halonitriles, e.g., 2,4-dichloro-2-fluoro-5,5-dimethoxy-4-methylpentanenitrile, method of preparation and use to make halopyridines, some of which are novel, e.g., 2-chloro-3-fluoro-5-methylpyridine. These compounds are intermediates in the preparation of pharmaceutical and agricultural products.

新型卤代腈化合物，例如2,4-二氯-2-氟-5,5-二甲氧基-4-甲基戊腈，其制备方法及用于制备卤代吡啶，其中一些是新型的，例如2-氯-3-氟-5-甲基吡啶。这些化合物是制备药物和农业产品的中间体。
Method for purifying acid chlorides

申请人：BASF Aktiengesellschaft

公开号：US06727384B1

公开（公告）日：2004-04-27

Process for the purification of carbonyl chlorides which have been prepared by reacting carboxylic acids with phosgene or thionyl chloride in the presence of a catalyst adduct, in which the carbonyl chlorides are treated with a hydrohalide of carboxamides of the formula (I) in which R1 is hydrogen or C1- to C3-alkyl; R2 and R3 independently of one another are C1- to C4-alkyl, or R2 and R3 together are a C4- or C5-alkylene chain, and the carbonyl chloride purified in this way is isolated by separation off from the carboxamide hydrohalide phase.

通过将用催化剂加合物在催化剂的存在下与光气或亚砜氯反应制备的羰基氯化物进行处理，以提纯羰基氯化物的方法，其中羰基氯化物与具有以下式（I）中R1为氢或C1至C3烷基的羧酰胺的氢卤酸盐反应；R2和R3彼此独立地为C1至C4烷基，或R2和R3一起为C4或C5烷基链，通过这种方式提纯的羰基氯化物通过与羧酰胺氢卤酸盐相分离而被分离出来。
Reversible Switching of the Coordination Modes of a Pyridine-Functionalized Quinonoid Zwitterion; Its Di- and Tetranuclear Palladium Complexes

作者：Alessio Ghisolfi、Audrey Waldvogel、Lucie Routaboul、Pierre Braunstein

DOI：10.1021/ic500194y

日期：2014.6.2

shift of the Pd(II) centers from the NPy sites to the N,O donor sites of the zwitterion core has occurred, resulting in a N2O2 tetradentate behavior of ligand L. Reaction of 4 with HCl regenerates 3 quantitatively. Chloride abstraction from 3 with AgOTf (OTf = trifluoromethanesulfonate) resulted in loss of one of the two dmba ligands and formation of an unusual tetranuclear Pd(II) complex, [Pd(dmba)}(μ-L)Pd]2(OTf)2

新型功能性醌类两性离子（E）-3-氧代-4-（（2-（吡啶-2-基）乙基）氨基）-6-（（2-2-吡啶-2-基）乙基）的配位化学在Pd（II）化学中，研究了CH 2 CH 2间隔基连接醌型核的N取代基和吡啶基的亚氨基）环己-1,4-二壬酸酯（2，H 2 L）。根据实验条件和试剂，观察到了不同的配位模式。H 2 L与[Pd（μ-Cl）（dmba）] 2（dmba = o -C 6 H 4 CH 2 NMe 2 - C，N的反应））得到双核络合物[PdCl（dmba）} 2（H 2 L）]（3），其中H 2 L充当N Py，N Py二齿配体。该复合物与NaH的去质子化导致形成双核复合物[Pd（dmba）} 2（μ-L）]（4），其中Pd（II）的中心从N Py位向N转移。，两性离子核的O供体位点已经出现，导致了配体L的N 2 O 2四齿行为。4与HCl的反应定量地再生了3。氯化物从3提取用AgOTf（OTf
[EN] PROCESS FOR PREPARATION OF LUTEOLIN<br/>[FR] PROCÉDÉ DE PRÉPARATION DE LUTÉOLINE

申请人：LAURUS LABS PRIVATE LTD

公开号：WO2013111148A1

公开（公告）日：2013-08-01

The present invention provides a process for preparation of Luteolin by deprotection of the corresponding ethers using Lewis acid mediated Ionic complexes, and to compositions containing the same.

本发明提供了一种通过使用Lewis酸介导的离子复合物去保护相应醚的方法，制备黄酮素的方法，并提供含有该物质的组合物。
Process for the preparation of 2-halogeno-5-cyano pyridines

申请人：Bayer Aktiengesellschaft

公开号：US05459273A1

公开（公告）日：1995-10-17

The title compounds of the formula ##STR1## can be prepared by reacting methylene-glutaconic acid dinitriles of the formula R.sup.1 --CH.dbd.C(CN)--CH'CH--CN (II) with hydrogen halide of the formula HX (III) In these formulae, X denotes fluorine, chlorine, bromine or iodine and R.sup.1 denotes --OR.sup.2 or --N(R.sup.2, R.sup.3), in which R.sup.2 and R.sup.3, independently of one another, represent straight-chain or branched C.sub.1 -C.sub.8 -alkyl, C.sub.3 -C.sub.8 -alkenyl, C.sub.2 -C.sub.8 -alkoxyalkyl, C.sub.4 -C.sub.8 -alkoxyalkenyl, C.sub.3 -C.sub.8 -cycloalkyl, C.sub.6 -C.sub.12 -aryl, C.sub.7 -C.sub.10 -aralkyl or a 5- to 8-membered saturated or unsaturated heterocyclic ring containing 1 or 2 heteroatoms from the group comprising N, O and S, where R.sup.2 and R.sup.3, with the N atom on which they are substituents, may also form a 5- to 8-membered ring which may contain a further heteroatom from the group comprising N, O and S.

公式 ##STR1## 的标题化合物可以通过将公式R.sup.1 --CH.dbd.C(CN)--CH'CH--CN (II) 的亚甲基戊二酸二腈与公式HX (III) 的氢卤酸反应制备。在这些公式中，X表示氟、氯、溴或碘，R.sup.1表示--OR.sup.2或--N(R.sup.2，R.sup.3)，其中R.sup.2和R.sup.3独立地表示直链或支链C.sub.1-C.sub.8烷基，C.sub.3-C.sub.8烯基，C.sub.2-C.sub.8烷氧基烷基，C.sub.4-C.sub.8烷氧基烯基，C.sub.3-C.sub.8环烷基，C.sub.6-C.sub.12芳基，C.sub.7-C.sub.10芳基烷基或含有1或2个来自N、O和S的杂原子的5-至8元饱和或不饱和杂环，其中R.sup.2和R.sup.3与它们所取代的N原子一起，也可以形成一个含有来自N、O和S的进一步杂原子的5-至8元环，

N,N-Dimethylformamide Hydrochloride | 3397-76-0

分子结构分类

物化性质

计算性质

安全信息

SDS

反应信息

文献信息

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