辛二亚氨酸二甲酯二盐酸盐

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 甲亚胺酸及其衍生物
• 中文名称: 辛二亚氨酸二甲酯二盐酸盐
• 中文别名: 辛二亚氨酸二甲酯.二盐酸盐；二甲基辛二硝酸二盐酸酯；二甲基辛二亚氨酸酯二盐酸盐
• 英文名称: (8-Azaniumylidene-1,8-dimethoxyoctylidene)azanium;dichloride
• 英文别名: (8-azaniumylidene-1,8-dimethoxyoctylidene)azanium;dichloride
• 化学式: C10H22Cl2N2O2
• 分子量: 273.2
• InChiKey: ILKCDNKCNSNFMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.42
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  66.2
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• Cobalamin conjugates for anti-tumor therapy
  申请人：Weinshenker M. Ned

  公开号：US20050054607A1

  公开（公告）日：2005-03-10

  The present invention provides a cobalamin-drug conjugate suitable for the treatment of tumor related diseases. Cobalamin is indirectly covalently bound to an anti-tumor drug via a cleavable linker and one or more optional spacers. Cobalamin is covalently bound to a first spacer or the cleavable linker via the 5′-OH of the cobalamin ribose ring. The drug is bound to a second spacer of the cleavable linker via an existing or added functional group on the drug. After administration, the conjugate forms a complex with transcobalamin (any of its isoforms). The complex then binds to a receptor on a cell membrane and is taken up into the cell. Once in the cell, an intracellular enzyme cleaves the conjugate thereby releasing the drug. Depending upon the structure of the conjugate, a particular class or type of intracellular enzyme affects the cleavage. Due to the high demand for cobalamin in growing cells, tumor cells typically take up a higher percentage of the conjugate than do normal non-growing cells. The conjugate of the invention advantageously provides a reduced systemic toxicity and enhanced efficacy as compared to a corresponding free drug.

  本发明提供了一种适用于治疗肿瘤相关疾病的钴胺素-药物结合物。钴胺素通过可切割的连接剂间接共价结合到抗肿瘤药物上，还可以通过一个或多个可选的间隔物。钴胺素通过其核糖环的5'-OH与第一间隔物或可切割连接剂共价结合。药物通过其现有或添加的功能基团与可切割连接剂的第二间隔物结合。在给药后，结合物与转钴胺素（其任何同工异构体）形成复合物。然后，该复合物结合到细胞膜上的受体并被细胞摄取。一旦进入细胞，细胞内酶将切割结合物，从而释放药物。根据结合物的结构，特定类别或类型的细胞内酶影响切割。由于生长细胞对钴胺素的需求量较高，肿瘤细胞通常摄取结合物的比例高于正常非生长细胞。本发明的结合物与相应的游离药物相比，具有较低的全身毒性和增强的疗效。
• Cobalamin mediated delivery of nucleic acids, analogs and derivatives thereof
  申请人：Collins A. Douglas

  公开号：US20060074034A1

  公开（公告）日：2006-04-06

  This invention is in the area of cobalamin-mediated delivery of nucleic acids and analogs and derivatives thereof to a host to affect gene expression.

  这项发明涉及钴胺素介导的核酸及其类似物和衍生物的传递到宿主以影响基因表达。
• [EN] FAST-DISSOLVE DOSAGE FORMS OF 5-HT2C AGONISTS<br/>[FR] FORMES POSOLOGIQUES À DISSOLUTION RAPIDE D'AGONISTES DE 5-HT2C
  申请人：ARENA PHARM INC

  公开号：WO2012030951A1

  公开（公告）日：2012-03-08

  Salts of the 5-HT2C-receptor agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, and dosage forms comprising them that are useful for, inter alia, weight management.

  ( R ) -8-氯-1-甲基-2,3,4,5-四氢-1H-3-苯并哌啶的5-HT2C受体激动剂盐，以及包含它们的剂型，可用于体重管理等用途。
• STIMULI-RESPONSIVE HYDROGEL
  申请人：Weber Wilfried

  公开号：US20110151006A1

  公开（公告）日：2011-06-23

  The present invention relates to a hydrogel comprising a polymer, a first polypeptide and a polypeptide binding partner, wherein the polypeptide binding partner is a second polypeptide, a nucleic acid or a small molecule, and wherein the interaction between the first polypeptide and the polypeptide binding partner stabilizes the hydrogel and is modulated by the addition of a modulating compound. A drug may be physically entrapped in the hydrogel, bound to the polymer forming the hydrogel structure, or bound to the first polypeptide or the polypeptide binding partner, and then be set free on addition of the modulating compound. Such a hydrogel comprising a drug may be injected into a patient, and drug release modulated by orally administering the modulating compound.

  本发明涉及一种水凝胶，其包含聚合物、第一多肽和多肽结合伴侣，其中多肽结合伴侣是第二多肽、核酸或小分子，并且第一多肽和多肽结合伴侣之间的相互作用稳定了水凝胶，并且可以通过添加调节化合物来调节。药物可以被物理地包裹在水凝胶中，结合在形成水凝胶结构的聚合物上，或结合在第一多肽或多肽结合伴侣上，并在添加调节化合物后释放。这样的含药水凝胶可以注射到患者体内，并通过口服调节化合物来调节药物释放。
• Immunoassays utilizing covalent conjugates of polymerized enzyme and antibody
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0175560A2

  公开（公告）日：1986-03-26

  An enzyme is cross-linked to form a polymerized enzyme which is covalently coupled to an antibody or antibody fragment. The use of the antibody-polymeric enzyme conjugate in immunoassays provides enhanced signal generation and, therefore, short assay time and high sensitivity.

  在免疫测定中使用抗体-聚合酶结合物可增强信号生成，从而缩短检测时间并提高灵敏度。

表征谱图