cholesterol m-nitrobenzoate | 40998-96-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: cholesterol m-nitrobenzoate
• 英文别名: 3β-(3-nitro-benzoyloxy)-cholestene-(5)；3β-(3-Nitro-benzoyloxy)-cholesten-(5)；[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] 3-nitrobenzoate
• CAS: 40998-96-7
• 化学式: C₃₄H₄₉NO₄
• 分子量: 535.767
• InChiKey: HWWNKOPGLSAYEI-AESKLMAPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.6
• 重原子数：
  39
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  二硫化碳 、 cholesterol m-nitrobenzoate 、 溴 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  The value of knee arthroscopy in patients with severe radiological osteoarthritis

  摘要：

  Background: This study was performed to assess the value of knee arthroscopy in patients with radiological signs of severe osteoarthritis. Methods: A total of 104 patients (50 men, 54 women, average age 60 years) with radiological knee osteoarthritis grade III/IV were followed up after knee arthroscopy between May 1989 and November 1996. The average follow-up time was 5.4 years after surgery. Results: A significant (p<0.01) increase in the Lysholm score was found, ranging from 40 points before arthroscopy to 69 points at the assessment. A total of 84 patients (81%) reported an increase in their activities of daily living, 44 patients (43%) were still without any complaints. The total outcome was rated very good or good by 67 patients (65%). Only 21 patients (20%) required further surgery before the assessment. Conclusions: Knee arthroscopy is a valuable treatment for patients with pain, swelling, and radiological signs of severe osteoarthritis. It improves the patients' activities of daily living and helps to postpone further surgery.

  DOI：

  10.1007/s00402-002-0425-4
• 作为产物：
  描述：

  cholesterol 、 间硝基苯甲酰氯 生成 cholesterol m-nitrobenzoate
  参考文献：
  名称：

  The value of knee arthroscopy in patients with severe radiological osteoarthritis

  摘要：

  Background: This study was performed to assess the value of knee arthroscopy in patients with radiological signs of severe osteoarthritis. Methods: A total of 104 patients (50 men, 54 women, average age 60 years) with radiological knee osteoarthritis grade III/IV were followed up after knee arthroscopy between May 1989 and November 1996. The average follow-up time was 5.4 years after surgery. Results: A significant (p<0.01) increase in the Lysholm score was found, ranging from 40 points before arthroscopy to 69 points at the assessment. A total of 84 patients (81%) reported an increase in their activities of daily living, 44 patients (43%) were still without any complaints. The total outcome was rated very good or good by 67 patients (65%). Only 21 patients (20%) required further surgery before the assessment. Conclusions: Knee arthroscopy is a valuable treatment for patients with pain, swelling, and radiological signs of severe osteoarthritis. It improves the patients' activities of daily living and helps to postpone further surgery.

  DOI：

  10.1007/s00402-002-0425-4

文献信息

• Sandqvist; Gorton, Chemische Berichte, 1930, vol. 63, p. 1759
  作者：Sandqvist、Gorton

  DOI：——

  日期：——
• US3975288A
  申请人：——

  公开号：US3975288A

  公开（公告）日：1976-08-17
• The value of knee arthroscopy in patients with severe radiological osteoarthritis
  作者：Michael Bohnsack、Wolfram Lipka、Oliver Rühmann、Gabriela Peters、Stefan Schmolke、Carl Wirth

  DOI：10.1007/s00402-002-0425-4

  日期：2002.11

  Background: This study was performed to assess the value of knee arthroscopy in patients with radiological signs of severe osteoarthritis. Methods: A total of 104 patients (50 men, 54 women, average age 60 years) with radiological knee osteoarthritis grade III/IV were followed up after knee arthroscopy between May 1989 and November 1996. The average follow-up time was 5.4 years after surgery. Results: A significant (p<0.01) increase in the Lysholm score was found, ranging from 40 points before arthroscopy to 69 points at the assessment. A total of 84 patients (81%) reported an increase in their activities of daily living, 44 patients (43%) were still without any complaints. The total outcome was rated very good or good by 67 patients (65%). Only 21 patients (20%) required further surgery before the assessment. Conclusions: Knee arthroscopy is a valuable treatment for patients with pain, swelling, and radiological signs of severe osteoarthritis. It improves the patients' activities of daily living and helps to postpone further surgery.