2-乙基-2,3-二氢-1-苯并噻吩 | 14422-09-4

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 中文名称: 2-乙基-2,3-二氢-1-苯并噻吩
• 英文名称: 2-Aethyl-2,3-dihydrobenzothiophen
• 英文别名: 2-Ethyl-2,3-dihydro-1-benzothiophene
• CAS: 14422-09-4
• 化学式: C₁₀H₁₂S
• 分子量: 164.271
• InChiKey: HKYGJTRLMKDUQT-UHFFFAOYSA-N

物化性质

• 沸点：
  138-141 °C(Press: 26 Torr)
• 密度：
  1.055±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (E)-but-2-en-1-yl phenyl sulfide 生成 2-乙基-2,3-二氢-1-苯并噻吩
  参考文献：
  名称：

  ABDIN T.; DANILOVA T. A.; VIKTOROVA E. A., ORGAN. SOEDIN. SERY. T. 2, RIGA, 1980, 460-463

  摘要：

  DOI：

文献信息

• 4'-O- substituted isoindoline derivatives and compositions comprising and methods of using the same
  申请人：Ruchelman Alexander L.

  公开号：US20090004209A1

  公开（公告）日：2009-01-01

  Provided are 4′-O substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.

  提供了4'-O取代的异吲哚啉化合物及其药学上可接受的盐、溶剂化合物、笼合物、立体异构体和前药。公开了这些化合物的使用方法和制药组合物。
• FAP inhibitors
  申请人：EVANS David Michael

  公开号：US20100081701A1

  公开（公告）日：2010-04-01

  The present invention concerns compounds, according to general formula (I), which find utility preferably for the treatment of cancer.

  本发明涉及一般式（I）的化合物，其主要用于癌症治疗。
• Nitrogen-containing bicyclic compounds useful as antibacterial agents
  申请人：Toyama Chemical Co., Ltd.

  公开号：EP2468743A1

  公开（公告）日：2012-06-27

  A nitrogen-containing heterocyclic compound represented by the general formula: wherein the dashed line represents a single bond or a double bond; R1, R2, R3, R4 and R5 independently represent a hydrogen atom, halogen atom, a lower alkyl, aryl, lower alkoxy or monocyclic heterocyclic group which may be substituted or the like; R6 represents a lower alkyl, aryl, monocyclic heterocyclic, bicyclic heterocyclic or tricyclic heterocyclic group which may be substituted; X1 represents a lower alkylene group or the like; X2 represents a lower alkylene, lower alkenylene or lower alkynylene group which may be substituted; X3 represents an oxygen atom, sulfur atom, a sulfinyl group, sulfonyl group or the like; Y1 represents a bivalent cyclic group, containing a nitrogen, which may be substituted or the like; and Z1 represents a nitrogen atom, a carbon atom which may be substituted or the like, or a salt thereof. The compound or salt has a potent antibacterial activity and a high safety, and is therefore useful as an excellent antibacterial agent.

  一种由通式表示的含氮杂环化合物：其中虚线代表单键或双键；R1、R2、R3、R4和R5独立地代表氢原子、卤素原子、低级烷基、芳基、低级烷氧基或可被取代的单环杂环基团或类似基团；R6代表可被取代的低级烷基、芳基、单环杂环基团、双环杂环基团或三环杂环基团；X1代表低级亚烷基或类似基团；X2 代表可被取代的低级亚烷基、低级亚烯基或低级亚炔基； X3 代表氧原子、硫原子、亚砜基、磺酰基或类似物； Y1 代表可被取代的含氮的二价环基或类似物； Z1 代表氮原子、可被取代的碳原子或类似物，或其盐。该化合物或其盐具有很强的抗菌活性和很高的安全性，因此可用作优良的抗菌剂。
• PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
  申请人：Amgen, Inc

  公开号：EP3483143A1

  公开（公告）日：2019-05-15

  The present invention provides MDM2 inhibitor compounds of Formula IE, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

  本发明提供了式 IE 的 MDM2 抑制剂化合物、 该化合物可用作治疗剂，特别是用于治疗癌症。本发明还涉及含有 MDM2 抑制剂的药物组合物。
• The Action of Heat on S-Crotylthiosalicylic Acid and Related Compounds
  作者：J. C. Petropoulos、M. A. McCall、D. S. Tarbell

  DOI：10.1021/ja01101a037

  日期：1953.3