24β_F-methyl-cholestatrien-(4.7.22t)-ol-(3α) | 6538-05-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 24β_F-methyl-cholestatrien-(4.7.22t)-ol-(3α)
• 英文别名: 3α-Hydroxy-10.13-dimethyl-17β-((1R:4R)-1.4.5-trimethyl-hexen-(2t)-yl)-gonadien-(4.7)；(10R)-3t-Hydroxy-10r.13c-dimethyl-17c-((1R:4R)-1.4.5-trimethyl-hexen-(2t)-yl)-(9tH.14tH)-Δ^4.7-dodecahydro-1H-cyclopenta[a]phenanthren；(24R)-24-Methyl-cholestatrien-(4.7.22t)-ol-(3α)；Ergost-4,7,22-trien-3alpha-ol；(3R,9S,10R,13R,14R,17R)-17-[(E,2R,5R)-5,6-dimethylhept-3-en-2-yl]-10,13-dimethyl-2,3,6,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol
• CAS: 6538-05-2
• 化学式: C₂₈H₄₄O
• 分子量: 396.657
• InChiKey: ZAILCZQBNDZEPC-AWYZMFRDSA-N

物化性质

• 沸点：
  502.6±49.0 °C(Predicted)
• 密度：
  1.00±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  麦角固醇 、 24β_F-methyl-cholestatrien-(4.7.22t)-ol-(3α) 生成 ergosterol; compound with ergostatrien-(4.7.22t)-ol-(3α)
  参考文献：
  名称：

  Windaus; Buchholz, Chemische Berichte, 1939, vol. 72, p. 597,599

  摘要：

  DOI：
• 作为产物：
  描述：

  (22E,24R)-ergosta-4,7,22-triene-3-one 在 aluminum isopropoxide 、 异丙醇 作用下， 生成 24β_F-methyl-cholestatrien-(4.7.22t)-ol-(3α)
  参考文献：
  名称：

  Sterols. XIX. epi-Ergosterol and epi-α-Ergostenol

  摘要：

  DOI：

  10.1021/ja01289a017

文献信息

• Barnett et al., Journal of the Chemical Society, 1940, p. 1390,1392
  作者：Barnett et al.

  DOI：——

  日期：——
• Heilbron et al., Journal of the Chemical Society, 1938, p. 869,874
  作者：Heilbron et al.

  DOI：——

  日期：——
• Climate Change and Trend Detection in Selected Rivers within the Asia-Pacific Region
  作者：Daniel Cluis、Claude Laberge

  DOI：10.1080/02508060108686933

  日期：2001.9

  Global climate change is currently an issue of great concern. This phenomenon was studied using the runoff of large rivers, which can be considered a regional integrator of the local precipitation occurring in their basins. The long-term stationarity and the possibility of trends in streamflow records stored in the databank of the Global Runoff Data Center (GRDC) at the Federal Institute of Hydrology in Koblenz (Germany) were studied. Runoff records originating from. 78 rivers with long monthly runoff series that are geographically distributed throughout the whole Asia-Pacific region were selected for study. For each of the selected rivers, three time series were constructed and analyzed: the mean yearly, and the maximum and minimum monthly discharges. These series were submitted to a two-tier analysis. First, a segmentation procedure developed by Hubert was applied to assess their stationarity. Then the segmented series were submitted to a specialized trend detection software. The results show that about two-thirds of the series have remained stationary and that the monthly minimum runoff exhibited more changing levels (37/78) than the mean (26/78) and maximum (18/78) runoff. Most of the detected changes occurred during the 1960s and 1970s, a period of rapid demographic expansion and urbanization in Asia, when irrigation and other water uses were developed, especially in tropical areas. During the same period and within the area studied, a number of large dams and reservoirs were completed. Since these anthropic interventions could be at the origin of the changes in runoff, there is no regionally consistent evidence supporting global climate change.
• An i-Steroid Hydrocarbon from Ergosterol¹
  作者：Mary Fieser、William E. Rosen、Louis F. Fieser

  DOI：10.1021/ja01141a052

  日期：1952.11
• Water Use and Protection in Rural Communities of the Peruvian Amazon Basin
  作者：Michael E. McClain、Luis Miguel Aparicio、Carlos A. Llerena

  DOI：10.1080/02508060108686932

  日期：2001.9

  Inhabitants of the Peruvian Amazon enjoy plentiful water and other aquatic resources that enhance their well-being in many ways. However, the intimate and generally unbuffered connection between the region's inhabitants and their water resources leads to complex negative feedbacks when these resources are mismanaged. Due to severe water problems in other, more populated, parts of the country the Peruvian government currently devotes little attention to water management in the Amazon. Thus, organized management is mainly left to individual communities and households. This study reports on the results of 351 interviews of households in the Pachitea Basin of the central Peruvian Amazon. Our aim is to quantify the use of water and other aquatic resources among different social groups and within different geographical settings of the region, With these data, we evaluate and identify priorities for community-driven water management in the region. We found that 50 to 90 percent of households take their water directly from primary sources, 35 to 94 percent transport it manually to their homes, and 50 to 75 percent practice only the simplest form of treatment (boiling). Indigenous households tended to rely less on water infrastructure and water treatment. Fish and an assortment Of other aquatic and riparian resources were important inputs to all social groups and in all geographic settings. Disposal of wastes in nearby water bodies was also found to be widespread. We conclude that water management efforts in the Pachitea Basin should focus on the protection of water quality in rivers and streams through careful disposal of wastes away from water bodies and the Preservation of natural water purification features such as riparian forests and wetlands. We also recommend developing a basin-wide master plan, which empowers end-users and integrates more detailed plans developed at community and association levels.