N-carbobenzyloxyurea | 49679-15-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-carbobenzyloxyurea
• 英文别名: benzyl alophanate；allophanic acid benzyl ester；Allophansaeure-benzylester；α-Allophanoyloxy-toluol；Benzyl-allophanat；Kohlensaeure-benzylester-ureid；Allophanic acid, benzyl ester；benzyl N-carbamoylcarbamate
• CAS: 49679-15-4
• 化学式: C₉H₁₀N₂O₃
• 分子量: 194.19
• InChiKey: OPNZKSWUAFBELV-UHFFFAOYSA-N

物化性质

• 熔点：
  185 °C
• 密度：
  1.278±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  81.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-carbobenzyloxyurea 生成 氰尿酸 、 苯甲醇
  参考文献：
  名称：

  Grandiere, Bulletin de la Societe Chimique de France, 1924, vol. <4> 35, p. 191

  摘要：

  DOI：
• 作为产物：
  描述：

  氨基甲酸苄酯 生成 N-carbobenzyloxyurea
  参考文献：
  名称：

  Metayer, Bulletin de la Societe Chimique de France, 1951, p. 802,805

  摘要：

  DOI：

文献信息

• A Simple, Efficient, Catalyst-Free and Solvent-Less Microwave-Assisted Process for N-Cbz Protection of Several Amines
  作者：Aouf, Zineb、Mansouri, Rachida、Lakrout, Salah、Berredjem, Malika、Aouf, Nour-Eddine

  DOI：10.5012/jkcs.2017.61.4.151

  日期：——

  A simple, green and chemo-selective method for the N-benzyloxycarbonylation of amines, $\beta}$-amino alcohols, $\alpha}$-amino esters and sulfonamides has been developed under microwave irradiation. Good to excellent yields of the N-benzyloxycarbamates compounds were obtained in short times without any side products.

  一种简单、绿色且选择性强的氨基、β-氨基醇、α-氨基酯和磺酰胺的N-苄氧羰基化方法已在微波辐射下开发。该方法在短时间内获得了良好到优秀的N-苄氧羰基氨基酸酯化合物产率，并且没有任何副产物。
• [EN] PROTEASE INHIBITORS<br/>[FR] INHIBITEURS DE PROTEASES
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2000038687A1

  公开（公告）日：2000-07-06

  The present invention provides 4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, novel intermediates of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting said bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.

  本发明提供了4-氨基-氮杂丙烷-3-酮蛋白酶抑制剂及其药学上可接受的盐、水合物和溶剂化物，其能够抑制蛋白酶，包括卡他普西蛋白酶K，还提供了这些化合物的制药组合物、这些化合物的新中间体以及用于治疗过度骨质流失或软骨或基质降解等疾病的方法，包括骨质疏松症；牙龈疾病，包括牙龈炎和牙周炎；关节炎，更具体地说是骨关节炎和类风湿性关节炎；帕吉特病；恶性高钙血症；以及代谢性骨病，通过向需要的患者施用本发明化合物来抑制骨质流失或过度软骨或基质降解。
• Process and intermediates for sorbinil
  申请人：PFIZER INC.

  公开号：EP0173522A2

  公开（公告）日：1986-03-05

  Chiral sorbinil intermediates of the formula wherein R is hydrogen or benzyloxycarbonyl and Y is hydroxy or amino, processes therefor, and processes forthe conversion thereof to sorbinil.

  式中 R 为氢或苄氧羰基，Y 为羟基或氨基的手性山梨醇中间体，以及将其转化为山梨醇的工艺。 式中 R 为氢或苄氧羰基，Y 为羟基或氨基的手性山梨醇中间体、其工艺以及将其转化为山梨醇的工艺。
• LUBRICATING OIL ADDITIVE AND LUBRICATING OIL COMPOSITION
  申请人：Nippon Oil Corporation

  公开号：EP1686167A1

  公开（公告）日：2006-08-02

  Lubricating oil compositions have low friction properties and anti-wear properties and are excellent in long drain capability. The lubricating oil compositions are particularly suitable for use as a fuel efficient type lubricating oil for internal combustion engines. The lubricating oil compositions contain a lubricating oil additive comprising one or more compounds selected from a specific nitrogen-containing compound, an acid-modified derivative thereof, and an oil soluble metal complex obtained by mixing the nitrogen-containing compound and/or acid-modified derivative thereof with an organic metal salt and/or organic metal complex.

  润滑油组合物具有低摩擦特性和抗磨损特性，并且具有出色的长换油期能力。润滑油组合物特别适合用作内燃机的节油型润滑油。润滑油组合物含有一种润滑油添加剂，该添加剂由一种或多种化合物组成，这些化合物选自特定的含氮化合物、其酸性改性衍生物以及通过将含氮化合物和/或其酸性改性衍生物与有机金属盐和/或有机金属复合物混合而获得的油溶性金属复合物。
• Lubricating oil additive and lubricating oil composition
  申请人：Nippon Oil Corporation

  公开号：EP2343354A1

  公开（公告）日：2011-07-13

  Lubricating oil compositions have low friction properties and anti-wear properties and are excellent in long drain capability. The lubricating oil compositions are particularly suitable for use as a fuel efficient type lubricating oil for internal combustion engines. The lubricating oil compositions contain a lubricating oil additive comprising one or more compounds selected from a specific nitrogen-containing compound, an acid-modified derivative thereof, and an oil soluble metal complex obtained by mixing the nitrogen-containing compound and/or acid-modified derivative thereof with an organic metal salt and/or organic metal complex.

  润滑油组合物具有低摩擦特性和抗磨损特性，并且具有出色的长换油期能力。润滑油组合物特别适合用作内燃机的节油型润滑油。润滑油组合物含有一种润滑油添加剂，该添加剂由一种或多种化合物组成，这些化合物选自特定的含氮化合物、其酸性改性衍生物以及通过将含氮化合物和/或其酸性改性衍生物与有机金属盐和/或有机金属复合物混合而获得的油溶性金属复合物。