N-((1R,2R)-1,3-bis(diphenylphosphinooxy)-1-(4-nitrophenyl)propan-2-yl)-2,2-dichloroacetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-((1R,2R)-1,3-bis(diphenylphosphinooxy)-1-(4-nitrophenyl)propan-2-yl)-2,2-dichloroacetamide
• 英文别名: N-[(1R,2R)-1,3-bis(diphenylphosphanyloxy)-1-(4-nitrophenyl)propan-2-yl]-2,2-dichloroacetamide
• 化学式: C₃₅H₃₀Cl₂N₂O₅P₂
• 分子量: 691.487
• InChiKey: XDVJJYNLNPQDDN-CZNDPXEESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.1
• 重原子数：
  46
• 可旋转键数：
  13
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  93.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  氯霉素 、 二苯基氯化膦 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 15.0h， 以51%的产率得到N-((1R,2R)-1,3-bis(diphenylphosphinooxy)-1-(4-nitrophenyl)propan-2-yl)-2,2-dichloroacetamide
  参考文献：
  名称：

  Asymmetric allylation of aldehydes with chiral platinum phosphinite complexes

  摘要：

  Platinum phosphinite complexes made from chiral diols catalyze the enantioselective allylation of cinnamaldehyde. This reaction proceeds with better yields at shorter reaction times in the presence of acetic acid. Enantiomeric excesses were greater when reactions were carried out with phosphinite ligands having hydrogen bond donors or acceptors. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2007.09.027

文献信息

• Asymmetric allylation of aldehydes with chiral platinum phosphinite complexes
  作者：Rakesh K. Sharma、Ashoka G. Samuelson

  DOI：10.1016/j.tetasy.2007.09.027

  日期：2007.10

  Platinum phosphinite complexes made from chiral diols catalyze the enantioselective allylation of cinnamaldehyde. This reaction proceeds with better yields at shorter reaction times in the presence of acetic acid. Enantiomeric excesses were greater when reactions were carried out with phosphinite ligands having hydrogen bond donors or acceptors. (c) 2007 Elsevier Ltd. All rights reserved.