[2-methyl-3-(2-methylphenyl)-4(3H)-quinazolinon-8-yloxy]acetohydrazide | 1319735-77-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: [2-methyl-3-(2-methylphenyl)-4(3H)-quinazolinon-8-yloxy]acetohydrazide
• 英文别名: 2-[3,4-dihydro-2-methyl-3-(2-methylphenyl)-4-oxoquinazolin-8-yloxy]acetic acid hydrazide；2-[2-methyl-3-(2-methylphenyl)-4-oxoquinazolin-8-yl]oxyacetohydrazide
• CAS: 1319735-77-7
• 化学式: C₁₈H₁₈N₄O₃
• 分子量: 338.366
• InChiKey: XVFPPZNQIGXCJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  97
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  [2-methyl-3-(2-methylphenyl)-4(3H)-quinazolinon-8-yloxy]acetohydrazide 在 吡啶 、 一水合肼 作用下， 以 乙醇 为溶剂， 反应 16.0h， 生成 N’-(hydrazinecarbonyl)-2-[(2-methyl-3-(2-methylphenyl)-4(3H)-quinazolin-8-yloxy)]acetohydrazide
  参考文献：
  名称：

  Synthesis and anticonvulsant evaluation of some new 2,3,8-trisubstituted-4(3H)-quinazoline derivatives

  摘要：

  A new series of 2,3,8-trisubstituted-4(3H)-quinazoline derivatives were synthesized, evaluated for their anticonvulsant activity against electrically (MES) and chemically (PTZ, picrotoxin and Strychnine) induced seizures and compared with the standard drugs methaqualone and sodium valproate. Compounds 3, 17 and 22 proved to be the most potent compounds of this series with relatively low neurotoxicity and low toxicity in the median lethal dose test as compared with the reference drugs. The obtained results showed that the most active compounds could be useful as a template for future design, modification and investigation to produce more active analogs. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.11.007
• 作为产物：
  描述：

  8-acetyloxy-2-methyl-4H-3,1-benzoxazin-4-one 在 potassium carbonate 、 一水合肼 作用下， 以 吡啶 、 甲醇 、 乙醇 、 丙酮 为溶剂， 反应 28.0h， 生成 [2-methyl-3-(2-methylphenyl)-4(3H)-quinazolinon-8-yloxy]acetohydrazide
  参考文献：
  名称：

  Synthesis and anticonvulsant evaluation of some novel 4(3H)-quinazolinones

  摘要：

  A series of novel quinazoline derivatives, methaqualone analogs, were synthesized, evaluated for their anticonvulsant activity against electrically and chemically (pentylenetetrazole, picrotoxin, and strychnine) induced seizures and compared with the standard drugs methaqualone and sodium valproate. 3,4-Dihydro-2-methyl-3-(2-methylphenyl)-4-oxoquinazolin-8-yl propanoate, benzenesulfonate, and 4-nitrobenzenesulfonate as well as 2-methyl-3-(2-methylphenyl)-8-methoxy-4(3H)-quinazolinone and 2-[3,4-dihydro-2-methyl-3-(2-methylphenyl)-4-oxoquinazolin-8-yloxy]acetic acid hydrazide were found to be the most potent compounds of this series accompanied with relatively low neurotoxicity and low toxicity in the median lethal dose test as compared with the reference drugs.

  DOI：

  10.1007/s00706-011-0525-3

文献信息

• Design, synthesis and anticonvulsant evaluation of novel 8-substituted-4(3H)-quinazolines
  作者：Adel S. El-Azab、Kamal E. H. ElTahir

  DOI：10.1007/s00044-011-9914-8

  日期：2012.11

  A new series of 8-substituted-4(3H)-quinazoline derivatives were synthesized, evaluated for their anticonvulsant activity against chemically (PTZ, picrotoxin and Strychnine) and electrically (MES) induced seizures and compared with the reference drugs valproate and methaqualone. Acid hydrazide, acetylhydrazine carboxylate and acetylhydrazinecarbodithioate were the most active compounds with relatively low neurotoxicity compared with the standard drugs. The obtained results proved that the mostly active compounds could be useful as a model for future design, adaptation and investigation to construct more active analogues.
• Synthesis and anticonvulsant evaluation of some novel 4(3H)-quinazolinones
  作者：Adel S. El-Azab、Kamal E. H. ElTahir、Sabry M. Attia

  DOI：10.1007/s00706-011-0525-3

  日期：2011.8

  A series of novel quinazoline derivatives, methaqualone analogs, were synthesized, evaluated for their anticonvulsant activity against electrically and chemically (pentylenetetrazole, picrotoxin, and strychnine) induced seizures and compared with the standard drugs methaqualone and sodium valproate. 3,4-Dihydro-2-methyl-3-(2-methylphenyl)-4-oxoquinazolin-8-yl propanoate, benzenesulfonate, and 4-nitrobenzenesulfonate as well as 2-methyl-3-(2-methylphenyl)-8-methoxy-4(3H)-quinazolinone and 2-[3,4-dihydro-2-methyl-3-(2-methylphenyl)-4-oxoquinazolin-8-yloxy]acetic acid hydrazide were found to be the most potent compounds of this series accompanied with relatively low neurotoxicity and low toxicity in the median lethal dose test as compared with the reference drugs.
• Synthesis and anticonvulsant evaluation of some new 2,3,8-trisubstituted-4(3H)-quinazoline derivatives
  作者：Adel S. El-Azab、Kamal E.H. ElTahir

  DOI：10.1016/j.bmcl.2011.11.007

  日期：2012.1

  A new series of 2,3,8-trisubstituted-4(3H)-quinazoline derivatives were synthesized, evaluated for their anticonvulsant activity against electrically (MES) and chemically (PTZ, picrotoxin and Strychnine) induced seizures and compared with the standard drugs methaqualone and sodium valproate. Compounds 3, 17 and 22 proved to be the most potent compounds of this series with relatively low neurotoxicity and low toxicity in the median lethal dose test as compared with the reference drugs. The obtained results showed that the most active compounds could be useful as a template for future design, modification and investigation to produce more active analogs. (C) 2011 Elsevier Ltd. All rights reserved.