2-(tert-butyl)-5-phenylfuran

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(tert-butyl)-5-phenylfuran
• 英文别名: 2-Tert-butyl-5-phenylfuran
• 化学式: C₁₄H₁₆O
• 分子量: 200.28
• InChiKey: QUWXBQMKKZGUCC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  13.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  新戊酰基乙酸甲酯 在 盐酸 、 sodium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 反应 6.05h， 生成 2-(tert-butyl)-5-phenylfuran
  参考文献：
  名称：

  Microwave-Assisted Paal−Knorr Reaction. A Rapid Approach to Substituted Pyrroles and Furans

  摘要：

  An array of tetrasubstituted pyrroles (and trisubstituted furans) was obtained using a simple three-step procedure. Functional homologation of beta-ketoester with an aldehyde followed by oxidation gave a series of differently substituted 1,4-dicarbonyl compounds that can be rapidly cyclized with the Paal-Knorr procedure carried out under microwave irradiation.

  DOI：

  10.1021/ol0362820

文献信息

• Hepatitis C Virus Inhibitors
  申请人：Bristol-Myers Squibb Company

  公开号：US20130183269A1

  公开（公告）日：2013-07-18

  The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

  本公开涉及抗病毒化合物，更具体地涉及能够抑制丙型肝炎病毒（HCV）编码的NS5A蛋白功能的化合物组合，包括这种组合的组成物，以及抑制NS5A蛋白功能的方法。
• Flexible metathesis-based approaches to highly functionalised furans and pyrroles
  作者：Timothy J. Donohoe、Neil M. Kershaw、Allan J. Orr、Katherine M.P. Wheelhouse (nee Gosby)、Lisa P. Fishlock、Adam R. Lacy、Matilda Bingham、Panayiotis A. Procopiou

  DOI：10.1016/j.tet.2007.09.087

  日期：2008.1.28

  have been synthesised in short order by the judicious use of a ring-closing metathesis/aromatisation strategy. Two contrasting approaches are described exploiting a palladium-catalysed union of allylic alcohols and sulfonamides in one case, and a titanium mediated methylenation of homoallylic esters in another. A number of groups that are difficult to install via traditional methods were incorporated

  通过明智地使用闭环复分解/芳构化策略，已在短时间内合成了一系列功能不同的呋喃和吡咯。描述了两种对比方法，一种是利用钯催化的烯丙基醇和磺酰胺的结合，另一种是利用钛介导的均烯丙基酯的甲基化。通过传统方法难以安装的许多组已成功合并。
• An expedient route to substituted furans via olefin cross-metathesis
  作者：Timothy J. Donohoe、John F. Bower

  DOI：10.1073/pnas.0913466107

  日期：2010.2.23

  of highly substituted derivatives are essential to medicinal chemistry. Here we show that the olefin CM reaction, in combination with an acid cocatalyst or subsequent Heck arylation, provides a concise and flexible entry to 2,5-di- or 2,3,5-tri-substituted furans. These cascade processes portend further opportunities for the regiocontrolled preparation of other highly substituted aromatic and heteroaromatic

  烯烃交叉复分解 (CM) 反应广泛用于有机化学，是选择性合成差异取代烯烃产物的有效方法。令人惊讶的是，尚未报道将这一非凡的过程整合到芳香族和杂芳香族构建策略中的努力。这种结构代表了大多数小分子药物化合物的关键要素；高度取代衍生物的受控制备方法对于药物化学是必不可少的。在这里，我们展示了烯烃 CM 反应与酸助催化剂或随后的 Heck 芳基化相结合，为 2,5-二-或 2,3,5-三-取代呋喃提供了简洁而灵活的入口。
• Iron-Catalyzed Oxidative Decarbonylative α-Alkylation of Acyl-Substituted Furans with Aliphatic Aldehydes as the Alkylating Agents
  作者：Wenkun Luo、Yongjie Yang、Bo Liu、Biaolin Yin

  DOI：10.1021/acs.joc.0c01002

  日期：2020.7.17

  protocol for FeCl2-catalyzed oxidative decarbonylative α-alkylation of acyl furans using alkyl aldehydes as the alkylating agents has been developed. This protocol affords α-alkyl-α-acylfurans in moderate to good yields in a practical and sustainable fashion. Mechanistic studies suggest that the reaction proceeds via generation of an alkyl radical from the alkyl aldehyde, addition of the radical to

  已经开发出使用烷基醛作为烷基化剂的FeCl 2催化酰基呋喃的氧化脱羰基α-烷基化的方案。该方案以实用和可持续的方式提供中等至良好收率的α-烷基-α-酰基呋喃。机理研究表明，该反应是通过由烷基醛生成烷基，将自由基加至呋喃环并随后进行重新芳构化来进行的。
• BENZIMIDAZOLIUM DYES AND THEIR USE AS FLUORESCENT CHEMOSENSORS
  申请人：CHANG Young-Tae

  公开号：US20080160521A1

  公开（公告）日：2008-07-03

  The present invention is directed toward benzimidazolium dye compounds of formula (I) as follows: wherein, n is an integer from 2-10, m is an integer from 2-10, X 1 and X 2 are independently a halogen, Q is H or a resin, and R is (aromatic) o -(linker) p -with the linker being saturated or unsaturated C 1 -C5 hydrocarbons, each aromatic independently being a substituted or unsubstituted aromatic or heteroaromatic, o being 1 or 2, and p being 0 or 1. Methods of making and using these compounds are also disclosed.

  本发明涉及如下式（I）的苯并咪唑盐染料化合物：其中，n为2-10的整数，m为2-10的整数，X1和X2分别为卤素，Q为氢或树脂，R为（芳香基）o-(连接体)p-，其中连接体为饱和或不饱和的C1-C5烃链，每个芳香基独立地为取代或未取代的芳香基或杂芳香基，o为1或2，p为0或1。同时还公开了制备和使用这些化合物的方法。