1,1,1-三氯丁烷 | 13279-85-1

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氯化物
• 中文名称: 1,1,1-三氯丁烷
• 英文名称: 1,1,1-trichloro-butane
• 英文别名: 1,1,1-Trichlor-butan；1,1,1-Trichlorobutane
• CAS: 13279-85-1
• 化学式: C₄H₇Cl₃
• 分子量: 161.459
• InChiKey: ABSHBZODGOHLFR-UHFFFAOYSA-N

物化性质

• 熔点：
  -6°C (estimate)
• 沸点：
  151.13°C (estimate)
• 密度：
  1.2310

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• 海关编码：
  2903199000

反应信息

• 作为反应物：
  描述：

  1,1,1-三氯丁烷 在 氯 作用下， 以 二硫化碳 为溶剂， 生成 1,1,1,3-四氯丁烷
  参考文献：
  名称：

  Burton,T.; Bruylants,A., Bulletin des Societes Chimiques Belges, 1972, vol. 81, p. 639 - 642

  摘要：

  DOI：
• 作为产物：
  描述：

  1,1-二氯丁烯 在 盐酸 、 三氯化铝 、 二氯甲烷 作用下， 生成 1,1,1-三氯丁烷
  参考文献：
  名称：

  Isomer Distribution in the Sulfuryl Chloride Chlorination of the 1-Chlorobutanes and Related Compounds; the Inductive Effect in Free Radical Substitutions¹

  摘要：

  DOI：

  10.1021/ja01620a019

文献信息

• [EN] PREPARATION OF MICAFUNGIN INTERMEDIATES<br/>[FR] PRÉPARATION D'INTERMÉDIAIRES DE LA MICAFUNGINE
  申请人：SANDOZ AG

  公开号：WO2013034670A1

  公开（公告）日：2013-03-14

  The present invention relates to the preparation of compounds, in particular to the preparation of compounds of formula (I), which may be used with a compound of formula (VI), or a salt thereof as intermediates for the preparation of antifungal agents, preferably micafungin (MICA) or a salt thereof.

  本发明涉及化合物的制备，特别是涉及制备式(I)的化合物，该化合物可与式(VI)的化合物或其盐一起用作制备抗真菌药物的中间体，优选是米卡氟胞聚糖（MICA）或其盐。
• [EN] PYRIMIDINE COMPOUNDS AND THEIR USE AS PESTICIDES<br/>[FR] COMPOSES DE PYRIMIDINE ET UTILISATION DE CEUX-CI COMME PESTICIDES
  申请人：SUMITOMO CHEMICAL CO

  公开号：WO2003076415A1

  公开（公告）日：2003-09-18

  The present invention relates to a pyrimidine compound of formula (1): wherein R1 is C3-C7 alkynyl; R2 is hydrogen, halogen, or C¿1?-C3 alkyl; and R?3 is C¿1-C8 alkyl that may be substituted with halogen or C1-C3 alkoxy, or C3-C6 cycloalkyl (that may be substituted with halogen or C1-C3 alkyl) C1-C3 alkyl; a pesticidal composition comprising the pyrimidine compound as an active ingredient; and a method for controlling pests comprising applying the pyrimidine compound to pests or habitats of pests.

  本发明涉及一种式（1）的嘧啶化合物：其中R1为C3-C7炔基；R2为氢、卤素或C1-C3烷基；R3为C1-C8烷基，可以被卤素或C1-C3烷氧基取代，或者C3-C6环烷基（可以被卤素或C1-C3烷基取代）C1-C3烷基；一种包含该嘧啶化合物作为活性成分的杀虫剂组合物；以及一种控制害虫的方法，包括将该嘧啶化合物施用于害虫或害虫栖息地。
• Noncardiotoxic pharmaceutical compounds
  申请人：Barbeau L. Donald

  公开号：US20060035863A1

  公开（公告）日：2006-02-16

  The present invention relates to novel noncardiotoxic compounds and pharmaceutical compositions useful in the treatment of a variety of disorders including the treatment of depression, allergies, psychoses, cancer and gastrointestinal disorders. In particular, the present invention describes pharmaceutical compositions that mitigate life-threatening arrhythmias such as torsade de pointes. Torsade de pointes is a particular cardiac problem associated with many therapeutic agents and has been implicated as a possible cause of sudden death, particularly in those individuals with a past history of disturbances of cardiac rhythm, myocardial infarction, congenital repolarization abnormalities and cardiac risk factors such as hyperlipidemia and age. This arrhythmia is a variant of paroxysmal ventricular tachycardia associated with a prolonged QTc interval or prominent U waves on the ECG. Torsade de pointes is potentially lethal because it can progress to ventricular fibrillation, life-threatening arrhythmias or precipitate sudden death.

  本发明涉及新型无心脏毒性化合物和药物组合物，用于治疗包括抑郁症、过敏、精神病、癌症和胃肠道疾病在内的各种疾病。具体而言，本发明描述了可以缓解危及生命的心律失常，例如扭转型尖波。扭转型尖波是与许多治疗剂相关的一种特殊心脏问题，已被指认为可能导致猝死的原因，特别是在那些有心脏节律紊乱、心肌梗死、先天性复极异常和心脏危险因素（如高脂血症和年龄）的个体中。这种心律失常是一种与心电图上QTc间期延长或U波显著的室性心动过速变异有关的心律失常。扭转型尖波有潜在致命性，因为它可能发展为室颤、危及生命的心律失常或引发猝死。
• METHOD FOR PRODUCING CYCLIC CARBONATE
  申请人：NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

  公开号：US20160145234A1

  公开（公告）日：2016-05-26

  Provided is a method for producing a cyclic carbonate obtained by reacting epoxide and carbon dioxide, the method being capable of efficiently producing a cyclic carbonate at a high conversion rate and a high yield, in which degradation of the catalyst over time is suppressed and catalytic activity hardly decreases. A method for producing a cyclic carbonate by reacting epoxide and carbon dioxide in the presence of a quaternary onium salt selected from the group consisting of a quaternary ammonium salt having a halogenated anion as a counter ion and a quaternary phosphonium salt having a halogenated anion as a counter ion, or in the presence of a solid catalyst obtained by immobilizing the quaternary onium salt onto a carrier, wherein an organohalogen compound containing at least one halogen atom in one molecule is added to the reaction system.

  提供了一种生产环状碳酸酯的方法，该方法通过反应环氧化物和二氧化碳获得，能够高效地以高转化率和高产率生产环状碳酸酯，同时抑制催化剂随时间降解并且催化活性几乎不会下降。在存在从属于具有卤素阴离子作为对离子的季铵盐和具有卤素阴离子作为对离子的季膦盐中选择的季铵盐，或者存在通过将季铵盐固定在载体上而获得的固体催化剂的情况下，通过在反应体系中添加含有至少一个卤素原子的有机卤素化合物来生产环状碳酸酯的方法。
• [EN] SYNTHESIS OF CYCLIC CARBONATES<br/>[FR] SYNTHÈSE DE CARBONATES CYCLIQUES
  申请人：AGENCY SCIENCE TECH & RES

  公开号：WO2014171894A1

  公开（公告）日：2014-10-23

  The present invention provides a method of synthesizing a cyclic carbonate comprising the step of reacting an alcohol with carbon dioxide.in the presence of a base.

  本发明提供了一种合成环状碳酸酯的方法，包括在碱存在下将醇与二氧化碳反应的步骤。