1-Butyl-2-(4-thiazolyl)-1H-benzimidazole | 51592-03-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-Butyl-2-(4-thiazolyl)-1H-benzimidazole
• 英文别名: 4-(1-butylbenzimidazol-2-yl)-1,3-thiazole
• CAS: 51592-03-1
• 化学式: C₁₄H₁₅N₃S
• 分子量: 257.359
• InChiKey: OSYBBZZMSRKKSW-UHFFFAOYSA-N

物化性质

• 熔点：
  70 °C
• 沸点：
  442.0±37.0 °C(Predicted)
• 密度：
  1.24±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  59
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  噻菌灵 、 alkaline earth salt of/the/ methylsulfuric acid 在 Amberlite IRA-400 (Cl^(1-)form) resin 作用下， 以 甲醇 为溶剂， 以93%的产率得到1-Butyl-2-(4-thiazolyl)-1H-benzimidazole
  参考文献：
  名称：

  Studies of antimicrobial activity of N-alkyl and N-acyl 2-(4-thiazolyl)-1H-benzimidazoles

  摘要：

  Various N-alkyl and N-acyl derivatives of 2-(4-thiazolyl)-1H-benzimidazole, an anthelmintic and systemic fungicide, were synthesized by polymer-supported reactions and screened for their antifungal and antibacterial potency to establish structure-activity relationships. (C) 2003 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ejps.2003.09.001

文献信息

• Studies of antimicrobial activity of N-alkyl and N-acyl 2-(4-thiazolyl)-1H-benzimidazoles
  作者：N.S Pawar、D.S Dalal、S.R Shimpi、P.P Mahulikar

  DOI：10.1016/j.ejps.2003.09.001

  日期：2004.2

  Various N-alkyl and N-acyl derivatives of 2-(4-thiazolyl)-1H-benzimidazole, an anthelmintic and systemic fungicide, were synthesized by polymer-supported reactions and screened for their antifungal and antibacterial potency to establish structure-activity relationships. (C) 2003 Elsevier B.V. All rights reserved.