[EN] POLYCATIONIC AMPHIPHILES AS ANTIMICROBIAL AGENTS<br/>[FR] COMPOSÉS AMPHIPHILES POLYCATIONIQUES COMME AGENTS ANTIMICROBIENS
申请人:UNIV TEMPLE
公开号:WO2015069764A1
公开(公告)日:2015-05-14
The present disclosure provides an antimicrobial composition including a polycationic amphiphile compound, and the method of making and the method of using such a compound or composition. The compound having the formula (I) or (II) R1, R2, R3, R4, R5, R6, R10, or R11 is H or a C1-12 alkyl unsubstituted or optionally substituted with a functional group such as -OH, -OR', -NH2, -NHR', -NR'2, -N-C(0)R', -N-C(0)CR'=CR', - SH, -SR', -0-C(0)R', -C(0)R', -CF3, -OCF3, halogen, benzyl, o-vinylbenzyl, m-vinylbenzyl, p- vinylbenzyl, phenyl, allyl, and substituted allyl. R7, R8 or R9 is a C1-12 alkyl unsubstituted or optionally substituted with a functional group such as -OH, -OR', -NH2, -NHR', -NR'2, -SH, - SR', -0-C(0)R', -C(0)R', -CF3, and -OCF3. R' is H or a C1-4 alkyl. X or Y is a halogen, m and n are integers in the range from 1 to 25.