uridine 2'-monobutyrate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: uridine 2'-monobutyrate
• 英文别名: [(2R,3R,4R,5R)-2-(2,4-dioxopyrimidin-1-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl] butanoate
• 化学式: C₁₃H₁₈N₂O₇
• 分子量: 314.295
• InChiKey: CLBADRMEDVTPBJ-FAQVLOEFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  125
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2,2,2-三氯丁酸乙酯 、 尿嘧啶核苷 以 N,N-二甲基甲酰胺 为溶剂， 反应 96.0h， 以35%的产率得到uridine 3'-monobutyrate
  参考文献：
  名称：

  Protease-catalyzed regioselective esterification of sugars and related compounds in anhydrous dimethylformamide

  摘要：

  DOI：

  10.1021/ja00210a045

文献信息

• Acyl ribonucleosides and acyl deoxyribonucleosides, compositions of, and methods of making same
  申请人：Kempers Peter

  公开号：US20070160554A1

  公开（公告）日：2007-07-12

  The present invention is concerned with acyl ribonucleosides and with acyl deoxyribonucleosides. It is furthermore concerned with an enzymatic process for the manufacture of acyl ribonucleosides and of acyl deoxyribonucleosides. It is furthermore concerned with the use of acyl ribonucleosides and of acyl deoxyribonucleosides for cosmetic and for pharmaceutical purposes and with their use as a food supplement for humans or animals. It is furthermore concerned with compositions containing acyl ribonucleosides and acyl deoxyribonucleosides, whereby these compositions are suitable for cosmetic or for pharmaceutical purposes or as food supplement.
• Protease-catalyzed regioselective esterification of sugars and related compounds in anhydrous dimethylformamide
  作者：Sergio. Riva、Joel. Chopineau、A. P. G. Kieboom、Alexander M. Klibanov

  DOI：10.1021/ja00210a045

  日期：1988.1