3,3-Bis(4-methoxyphenyl)pentanedial | 115933-12-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,3-Bis(4-methoxyphenyl)pentanedial
• CAS: 115933-12-5
• 化学式: C₁₉H₂₀O₄
• 分子量: 312.365
• InChiKey: DUEMQKZRXRSFIR-UHFFFAOYSA-N

物化性质

• 沸点：
  444.7±45.0 °C(predicted)
• 密度：
  1.122±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,3-Bis(4-methoxyphenyl)pentanedial 、 4-氨基丁酸甲酯盐酸盐 在 molecular sieve 、 三乙胺 作用下， 以 氯仿 为溶剂， 反应 21.0h， 以18%的产率得到5-[4,4-Bis-(4-methoxy-phenyl)-4H-pyridin-1-yl]-pentanoic acid methyl ester
  参考文献：
  名称：

  Antihypertensive dihydropyridines with 1,4,4-trisubstitution

  摘要：

  Dihydropyridines with 1,4,4-trisubstitution were synthesized and tested for antihypertensive activity in a spontaneously hypertensive rat model. This substitution pattern on the dihydropyridine nucleus differs markedly from that found most active in the structure-activity relationship established for nifedipine-like compounds. However, some were found to significantly lower blood pressure at testing doses (30 mg/kg, ip and 100 mg/kg, po) for up to 24 h. Methyl 1,4-dihydro-4,4-dimethyl-1-pyridinepropanoate (2-1), for example, lowered blood pressure 71 mmHg at 30 mg/kg, ip and the effect endured for greater than 24 h. Unlike prototypical dihydropyridines such as nifedipine, these compounds did not seem to have any effect on calcium channels.

  DOI：

  10.1021/jm00163a037

文献信息

• [EN] SULFONYL-CONTAINING POLYMERS BASED ON FREE-RADICALLY POLYMERIZABLE SPIROBISINDANE MONOMERS<br/>[FR] POLYMÈRES À BASE DE MONOMÈRES DE SPIRO-BIS-INDANE POLYMÉRISABLES PAR VOIE RADICALAIRE CONTENANT UN SULFONYLE
  申请人：3M INNOVATIVE PROPERTIES CO

  公开号：WO2014186094A1

  公开（公告）日：2014-11-20

  Sulfonyl-containing polymeric materials and methods of making these materials are provided. More specifically, the sulfonyl-containing polymeric materials are prepared by treating a precursor polymeric material with a sulfonyl-containing compound. The precursor polymeric material is formed from a polymerizable composition that contains a free-radically polymerizable spirobisindane monomer. The sulfonyl-containing polymeric material is porous. The size of the pores can be in the microporous region, mesoporous region, or both depending on the particular monomers and reaction conditions used to form the precursor polymeric material.
• [EN] SULFONIC ACID-CONTAINING POLYMERIC MATERIALS AS AMINE SORBENTS<br/>[FR] MATÉRIAUX POLYMÈRES CONTENANT DE L'ACIDE SULFONIQUE À TITRE DE SORBANTS AMINÉS
  申请人：3M INNOVATIVE PROPERTIES CO

  公开号：WO2015191291A1

  公开（公告）日：2015-12-17

  A method of capturing a basic, nitrogen-containing compound is provided. The basic, nitrogen-containing compound is captured by sorption (e.g., adsorption) on a sulfonic-acid containing polymeric material. The sulfonic acid-containing polymeric material is formed from a polymerizable composition that contains a free-radically polymerizable spirobisindane monomer. Additionally, a polymeric material is provided that is a reaction product of a sulfonic acid-containing polymeric material having at least one -SO3H group and a basic, nitrogen-containing compound of formula Q. This polymeric material has at least one group of formula -SO3-(QH+).