合成了单-和二-碘全氟烷基醚,并研究了它们与碘氟烷烃与4-碘联苯胺的反应。C 8 F 17 C 6 H 4 CHO,C 8 F 17 C 6 H 4 CO 2 H,C 8 F 17 C 6 H 4 COCOC 6 H 5和C 8 F 17 OCF 2 CF 2 C 6 H的形成4可可6 H 5进行得很顺利。在铜青铜的存在下,由C 8 F 17 OCF 2 I与4-碘代苯甲腈的反应没有产生C 8 F 17 OCF 2 C 6 H 4 COCOC 6 H 5。从ICF 2 CF 2 O(CF 2)5 OCF 2 CF 2 I和I(CF 2 CF 2 O)5 CF 2 CF 2的偶联反应中获得低产率的桥联联苯。我用4-碘苯苄。根据形成的副产物,推测其作用机理。
Abstract A novel copper-catalyzed approach to benzils from readily available deoxybenzoins under neutral conditions using air as the oxidant has been developed. The reaction tolerates a variety of useful substituents including chloro, bromo, iodo, keto, ester, and cyano groups. A novel copper-catalyzed approach to benzils from readily available deoxybenzoins under neutral conditions using air as the
the visible light induced simple copper(II) chloride catalyzedoxidation of diarylacetylenes to α-diketones by molecular oxygen at roomtemperature. The in situ generated copper(II)-superoxo complex is a light-absorbing species that oxidizes inert diarylacetylenes to α-diketones. In contrast to reported photochemical processes, the current oxidation protocol does not require any exogenous photocatalyst
Copper-Catalyzed Direct Synthesis of Diaryl 1,2-Diketones from Aryl Iodides and Propiolic Acids
作者:Hongkeun Min、Thiruvengadam Palani、Kyungho Park、Jinil Hwang、Sunwoo Lee
DOI:10.1021/jo501089k
日期:2014.7.3
via the direct decarboxylativecoupling reaction of aryl propiolicacids and their oxidation. The optimized conditions are that the reaction of aryl propiolicacids and aryl iodides is conducted at 140 °C for 6 h in the presence of 10 mol % CuI/Cu(OTf)2 and Cs2CO3, after which HI (aq) is added and further reacted. The method shows good functional group tolerance toward ester, aldehyde, cyano, and nitro
通过芳基丙酸的直接脱羧偶联反应及其氧化反应合成苯甲醚衍生物,例如二芳基1,2-二酮。优化的条件是在10 mol%CuI / Cu(OTf)2和Cs 2 CO 3的存在下,芳基丙酸和芳基碘化物的反应在140°C下进行6 h ,之后HI(aq)为加入并进一步反应。该方法显示出对酯,醛,氰基和硝基的良好官能团耐受性。另外,在钯和铜催化剂的存在下,从芳基碘化物和丙酸获得对称的二芳基1,2-二酮。
Cobalt(<scp>ii</scp>) catalyzed C(sp)–H bond functionalization of alkynes with phenyl hydrazines: facile access to diaryl 1,2-diketones
作者:Jaideep B. Bharate、Sheenu Abbat、Rohit Sharma、Prasad V. Bharatam、Ram A. Vishwakarma、Sandip B. Bharate
DOI:10.1039/c5ob00419e
日期:——
A cobalt acetylacetonate catalyzed oxidative diketonation of alkynes via C(sp)–H bond functionalization has been described. The reaction involves a free-radical mechanism, wherein the phenyl radical formed from phenyl hydrazine couples with Co(II) activated alkyne to produce 1,2-diketones. The reaction proceeds at room temperature in DMF with the use of Ag2O/air as the oxidizing system. The utility
已经描述了乙酰丙酮钴通过C(sp)–H键官能化催化炔烃的氧化二酮化反应。该反应涉及自由基机理,其中由苯基肼形成的苯基与Co(II)活化的炔烃偶合以产生1,2-二酮。反应在室温下在DMF中使用Ag 2 O /空气作为氧化体系进行。已证明该方案可用于合成一系列咪唑类化合物,其中包括有效的血小板凝集抑制剂曲非那格雷。
Iron-Promoted C–C Bond Cleavage of 1,3-Diketones: A Route to 1,2-Diketones under Mild Reaction Conditions
A conceptual method for the preparation of 1,2-diketones is reported. The selective C–C bond cleavage of 1,3-diketones affords the 1,2-diketones in high yields under mild reaction conditions in air by the use of FeCl3 as the catalyst and tert-butyl nitrite (TBN) as the oxidant without the use of solvent. The possible reaction mechanism is discussed. This protocol provides an expeditious route to the