2-(4-(3-(2-chloro-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethyl pivalate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 2-(4-(3-(2-chloro-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethyl pivalate
• 英文别名: 2-[4-[3-(2-Chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl 2,2-dimethylpropanoate
• 化学式: C₂₆H₃₄ClN₃O₂S
• 分子量: 488.094
• InChiKey: DWFNWQZFSUDBFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  61.3
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  perphenazine N-Boc-4-aminobutyrate 在 三乙胺 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 22.0h， 生成 2-(4-(3-(2-chloro-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethyl pivalate
  参考文献：
  名称：

  WO2006/131923

  摘要：

  公开号：

文献信息

• Salts of conjugated psychotropic drugs and processes of preparing same
  申请人：Ramot at Tel-Aviv University Ltd.

  公开号：EP2272537A2

  公开（公告）日：2011-01-12

  Novel chemical conjugates of a psychotropic drug residue and an amino-containing organic acid residue selected to reduce side effects induced by the psychotropic drug when administered per se, to enhance the therapeutic activity of the psychotropic drug and/or to exert anti-proliferative activity, in which the amino group is in the form of an acid addition salt thereof and which are characterized by high stability are disclosed. Further disclosed are processes for preparing the chemical conjugates and addition salts thereof, pharmaceutical compositions containing the chemical conjugates and methods utilizing the chemical conjugates for treating various medical conditions.

  本发明公开了由一种精神药物残基和一种含氨基有机酸残基组成的新型化学共轭物，这些化学共轭物被选择用于减少精神药物本身给药时引起的副作用、增强精神药物的治疗活性和/或发挥抗增殖活性，其中氨基以其酸加成盐的形式存在，其特点是稳定性高。还公开了制备化学共轭物及其加成盐的工艺、含有化学共轭物的药物组合物以及利用化学共轭物治疗各种病症的方法。
• NOVEL SALTS OF CONJUGATED PSYCHOTROPIC DRUGS AND PROCESSES OF PREPARING SAME
  申请人：Ramot at Tel Aviv University Ltd.

  公开号：EP1888120A2

  公开（公告）日：2008-02-20
• Novel salts of conjugated psychotropic drugs and processes of preparing same
  申请人：Nudelman Abraham

  公开号：US20090298814A1

  公开（公告）日：2009-12-03

  Novel chemical conjugates of a psychotropic drug residue and an amino-containing organic acid residue selected to reduce side effects induced by the psychotropic drug when administered per se, to enhance the therapeutic activity of the psychotropic drug and/or to exert anti-proliferative activity, in which the amino group is in the form of an acid addition salt thereof and which are characterized by high stability are disclosed. Further disclosed are processes for preparing the chemical conjugates and addition salts thereof, pharmaceutical compositions containing the chemical conjugates and methods utilizing the chemical conjugates for treating various medical conditions.
• [EN] NOVEL SALTS OF CONJUGATED PSYCHOTROPIC DRUGS AND PROCESSES OF PREPARING SAME<br/>[FR] NOUVEAUX SELS DE MEDICAMENTS PSYCHOTROPES CONJUGUES ET LEURS PROCEDES DE PREPARATION
  申请人：UNIV RAMOT

  公开号：WO2006131923A2

  公开（公告）日：2006-12-14

  [EN] Novel chemical conjugates of a psychotropic drug residue and an amino-containing organic acid residue selected to reduce side effects induced by the psychotropic drug when administered per se, to enhance the therapeutic activity of the psychotropic drug and/or to exert anti-proliferative activity, in which the amino group is in the form of an acid addition salt thereof and which are characterized by high stability are disclosed. Further disclosed are processes for preparing the chemical conjugates and addition salts thereof, pharmaceutical compositions containing the chemical conjugates and methods utilizing the chemical conjugates for treating various medical conditions.
  [FR] L'invention concerne de nouveaux conjugués chimiques d'un résidu médicamenteux psychotrope et d'un résidu d'acide organique contenant des amines choisi pour réduire les effets secondaires induits par le médicament psychotrope lorsqu'il est administré tel quel, pour renforcer son activité thérapeutique et/ou pour exercer une activité antiproliférative, le groupe aminé étant sous la forme d'un sel addition d'acide de ces conjugués et se caractérisant par une stabilité élevée. L'invention concerne en outre des procédés de préparation des conjugués chimiques et de leurs sels d'addition, des compositions pharmaceutiques contenant des conjugués chimiques et leurs procédés d'utilisation pour traiter divers états médicaux.
• WO2006/131923
  申请人：——

  公开号：——

  公开（公告）日：——