5,6-dimethoxy-2-diethylamino-1,2,3,4-tetrahydronaphthalene | 58352-85-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 5,6-dimethoxy-2-diethylamino-1,2,3,4-tetrahydronaphthalene
• 英文别名: 5,6-Dimethoxy-2-diethylamino-1,2,3,4-tetrahydronaphthalin；N,N-diethyl-5,6-dimethoxy-1,2,3,4-tetrahydronaphthalen-2-amine
• CAS: 58352-85-5
• 化学式: C₁₆H₂₅NO₂
• 分子量: 263.38
• InChiKey: YIAHAAKWZWFRQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5,6-dimethoxy-2-diethylamino-1,2,3,4-tetrahydronaphthalene 在 氢碘酸 、 乙酸酐 作用下， 生成 TL 259
  参考文献：
  名称：

  Synthesis and pharmacology of some 2-aminotetralins. Dopamine receptor agonists

  摘要：

  A series of 2-amino-1,2,3,4-tetrahydronaphthalene compounds bearing substituents on the nitrogen and in the aromatic ring was synthesized from beta-tetralone intermediates. Compounds were screened in vivo for dopaminergic activity using tests in which apomorphine was especially active. It was found that apparent dopaminergic activity is inherent in 2-dialkylaminotetralins, the dipropylamine substitution being the most consistently productive amine group studies. Activity was greatly enhanced by proper substitution in the aromatic ring. The 5,6-dihydroxy group was the best potentiating group found. These data support the idea that the extended conformation for the phenylethylamine moiety of ampmorphine and dopamine is favorable for dopaminergic agonist activity. They also suggest that an unetherified catechol group may not be essential for such activity.

  DOI：

  10.1021/jm00238a008
• 作为产物：
  描述：

  1,2,6-三甲氧基萘 在 乙醇 、 sodium 作用下， 生成 5,6-dimethoxy-2-diethylamino-1,2,3,4-tetrahydronaphthalene
  参考文献：
  名称：

  Synthesis and pharmacology of some 2-aminotetralins. Dopamine receptor agonists

  摘要：

  A series of 2-amino-1,2,3,4-tetrahydronaphthalene compounds bearing substituents on the nitrogen and in the aromatic ring was synthesized from beta-tetralone intermediates. Compounds were screened in vivo for dopaminergic activity using tests in which apomorphine was especially active. It was found that apparent dopaminergic activity is inherent in 2-dialkylaminotetralins, the dipropylamine substitution being the most consistently productive amine group studies. Activity was greatly enhanced by proper substitution in the aromatic ring. The 5,6-dihydroxy group was the best potentiating group found. These data support the idea that the extended conformation for the phenylethylamine moiety of ampmorphine and dopamine is favorable for dopaminergic agonist activity. They also suggest that an unetherified catechol group may not be essential for such activity.

  DOI：

  10.1021/jm00238a008

文献信息

• Emetic tetralones and the use thereof for inducing regurgitation
  申请人：Burroughs Wellcome Co.

  公开号：US04064271A1

  公开（公告）日：1977-12-20

  5,6-Dialkoxy-2-tetralones (I) are disclosed as useful intermediates in the synthesis of 2-amino-5,6-dialkoxytetralins (III) and 2-amino-5,6-dihydroxytetralins (IV). Compounds of the groups III and IV are potent emetics.

  5,6-二烷氧基-2-四酮（I）被披露为合成2-氨基-5,6-二烷氧基四氢萘（III）和2-氨基-5,6-二羟基四氢萘（IV）的有用中间体。III和IV组的化合物是有效的呕吐剂。
• US4064271A
  申请人：——

  公开号：US4064271A

  公开（公告）日：1977-12-20
• Synthesis and pharmacology of some 2-aminotetralins. Dopamine receptor agonists
  作者：John D. McDermed、Gerald M. McKenzie、Arthur P. Phillips

  DOI：10.1021/jm00238a008

  日期：1975.4

  A series of 2-amino-1,2,3,4-tetrahydronaphthalene compounds bearing substituents on the nitrogen and in the aromatic ring was synthesized from beta-tetralone intermediates. Compounds were screened in vivo for dopaminergic activity using tests in which apomorphine was especially active. It was found that apparent dopaminergic activity is inherent in 2-dialkylaminotetralins, the dipropylamine substitution being the most consistently productive amine group studies. Activity was greatly enhanced by proper substitution in the aromatic ring. The 5,6-dihydroxy group was the best potentiating group found. These data support the idea that the extended conformation for the phenylethylamine moiety of ampmorphine and dopamine is favorable for dopaminergic agonist activity. They also suggest that an unetherified catechol group may not be essential for such activity.