7-异丙基-1-四氢萘酮 | 35338-72-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 中文名称: 7-异丙基-1-四氢萘酮
• 英文名称: 7-isopropyl-3,4-dihydro-2H-naphthalen-1-one
• 英文别名: 7-Isopropyl-3,4-dihydro-2H-naphthalin-1-on；4-Oxo-6-isopropyl-tetralin；7-Isopropyl-tetralon-(1)；8-Oxo-2-isopropyl-5.6.7.8-tetrahydro-naphthalin；7-isopropyl-1-tetralone；7-propan-2-yl-3,4-dihydro-2H-naphthalen-1-one
• CAS: 35338-72-8
• 化学式: C₁₃H₁₆O
• mdl: MFCD11518805
• 分子量: 188.269
• InChiKey: FTTPUMZADACVGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.461
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  7-异丙基-1-四氢萘酮 在 乙醚 作用下， 生成 7-異丙-1-甲萘
  参考文献：
  名称：

  Barnett; Sanders, Journal of the Chemical Society, 1933, p. 434,436

  摘要：

  DOI：
• 作为产物：
  描述：

  4-异丙基苯乙醇 在 硫酸 、 三溴化磷 、 苯 作用下， 生成 7-异丙基-1-四氢萘酮
  参考文献：
  名称：

  Bradfield et al., Journal of the Chemical Society, 1936, p. 667,675

  摘要：

  DOI：

文献信息

• A Facile, Catalytic Deoximation Method Using Potassium Bromide and Ammonium Heptamolybdate in the Presence of Hydrogen Peroxide in an Aqueous Medium
  作者：Nemai Ganguly、Sujoy Barik

  DOI：10.1055/s-2008-1032035

  日期：2008.2

  procedure for the cleavage of a wide range of ketoximes and aldoximes to the corresponding carbonyl compounds in an aqueous medium using catalytic amounts of potassium bromide and ammonium heptamolybdate tetrahydrate in combination with 30% hydrogen peroxide is described.

  描述了一种使用催化量的溴化钾和四水合七钼酸铵与 30% 过氧化氢相结合的简单、温和和有效的方法，用于在水性介质中将各种酮肟和醛肟裂解为相应的羰基化合物。
• Convenient, Mild Catalytic Deprotection of Oximes to Carbonyl Compounds with Hydrogen Peroxide and Iodine Catalyst in Aqueous Acetonitrile
  作者：Nemai C. Ganguly、Subhasis Nayek、Sujoy Kumar Barik

  DOI：10.1080/00397910902883678

  日期：2009.10.21

  Abstract A clean, mild, and efficient catalytic deoximation procedure compatible with several common functional groups has been developed using 30% hydrogen peroxide activated by iodine catalyst in aqueous acetonitrile under essentially neutral conditions. The mechanistic features of an iodonium ion–driven nucleophilic cleavage of oximic C˭N have been revealed.

  摘要 在基本中性条件下，在乙腈水溶液中，使用由碘催化剂活化的 30% 过氧化氢，开发了一种清洁、温和、高效的催化脱肟过程，与几种常见的官能团兼容。已经揭示了碘鎓离子驱动的肟 C˭N 亲核裂解的机制特征。
• Phosphonic acid compounds, their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US05716944A1

  公开（公告）日：1998-02-10

  The present invention relates to a compound of the general formula (I): ##STR1## wherein ring A is a benzene ring that may be substituted; Y is a divalent group as a constituent member of ring B forming a 5- to 8-membered ring; Q.sub.1 is a group of the formula --X--P(O)(OR.sup.1)(OR.sup.2) wherein X is a bond or a divalent group; R.sup.1 and R.sup.2, identical or different, are hydrogen or a lower alkyl, or may be combined together to form a ring; Q.sub.2 is hydrogen, a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; and the group of the formula --CON(Q.sub.1)(Q.sub.2) is connected to the a- or b-position carbon atom, or a salt thereof, which is useful as prophylactic and therapeutic agents of various metabolic bone diseases such as osteoporosis.

  本发明涉及一种具有一般式(I)的化合物：##STR1## 其中环A是可能被取代的苯环；Y是构成5-到8-成员环的环B的一个成员的二价基团；Q.sub.1是具有式--X--P(O)(OR.sup.1)(OR.sup.2)的基团，其中X是键或二价基团；R.sup.1和R.sup.2，相同或不同，是氢或较低的烷基，或可结合在一起形成环；Q.sub.2是氢、可能被取代的烃基或可能被取代的杂环基团；以及具有式--CON(Q.sub.1)(Q.sub.2)的基团连接到a-或b-位置的碳原子，或其盐，其作为各种代谢性骨疾病如骨质疏松症的预防和治疗剂。
• Methods and Compositions for the Treatment of Disease with Immune Stimulatory Conjugates
  申请人：Silverback Therapeutics, Inc.

  公开号：US20200113912A1

  公开（公告）日：2020-04-16

  Methods and conjugates are disclosed for alleviating toxicity(ies) associated with administration of immune-stimulatory conjugates, and in particular for alleviating toxicity(ies) associated with intravenous administration of such conjugates.

  本发明揭示了用于减轻与免疫刺激共轭物的给药相关的毒性的方法和共轭物，并且特别用于减轻与静脉给药这类共轭物相关的毒性。
• Methods for making retinoids and uses thereof
  申请人：Brouillette Wayne J.

  公开号：US20100204327A1

  公开（公告）日：2010-08-12

  Described herein are methods for making retinoids. Also described herein are retinoids and methods of use thereof.

  本文描述了制备视黄醇类化合物的方法。同时也描述了视黄醇类化合物及其使用方法。

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