Dns2-lysine | 141425-84-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Dns2-lysine
• 英文别名: Bis(dansyl)lysin；2,6-bis[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]hexanoic acid
• CAS: 141425-84-5
• 化学式: C₃₀H₃₆N₄O₆S₂
• 分子量: 612.771
• InChiKey: OLAZYTPTPLUAPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  42
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  153
• 氢给体数：
  3
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  Dns2-lysine 、 mercury dichloride 以 氘代二甲亚砜 、 水 为溶剂， 生成
  参考文献：
  名称：

  Tridentate Lysine-Based Fluorescent Sensor for Hg(II) in Aqueous Solution

  摘要：

  A novel homoplastic podand fluorescent sensor based on flexible hydrophilic lysine was prepared. Lysine with two dansyl groups-appended at both ends supplied a possibility for a tridentate binding toward Hg(II) and finally resulted in a unique selectivity to Hg(II) over other transition-metal ions with a hypersensitivity (detection limit 2.0 nM) in neutral buffered aqueous solutions. Notably, the coordination of chloride ion to the complex of sensor-Hg(II) brought forth that the trend in the NMR chemical shift for hydrogen and carbon atoms of the sensor was contrary to the findings in the former reports, which shows upfield shifts for the hydrogens and the alkane carbons but downfield shifts for the dansyl carbons, respectively.

  DOI：

  10.1021/ic200790g
• 作为产物：
  描述：

  丹酰氯 在 钯 甲酸 、 碳酸氢钠 作用下， 以 甲醇 、 水 、 丙酮 为溶剂， 反应 4.5h， 生成 Dns2-lysine
  参考文献：
  名称：

  Determination of enantiomeric purity of commercial 14C- and 3H-labeled L-α-amino acids

  摘要：

  DOI：

  10.1002/(sici)1099-1344(199806)41:6<477::aid-jlcr104>3.0.co;2-3

文献信息

• US7396859B2
  申请人：——

  公开号：US7396859B2

  公开（公告）日：2008-07-08
• Determination of enantiomeric purity of commercial 14C- and 3H-labeled L-α-amino acids
  作者：Joseph W. Lefevre、Neil J. Bonzagni、Lara L. Chappell、David J. Clement、Jeb R. Albro、Denise M. Lezynski

  DOI：10.1002/(sici)1099-1344(199806)41:6<477::aid-jlcr104>3.0.co;2-3

  日期：1998.6
• Tridentate Lysine-Based Fluorescent Sensor for Hg(II) in Aqueous Solution
  作者：Liping Chen、Liting Yang、Hongwei Li、Yang Gao、Dayi Deng、Yuqing Wu、Li-jun Ma

  DOI：10.1021/ic200790g

  日期：2011.10.17

  A novel homoplastic podand fluorescent sensor based on flexible hydrophilic lysine was prepared. Lysine with two dansyl groups-appended at both ends supplied a possibility for a tridentate binding toward Hg(II) and finally resulted in a unique selectivity to Hg(II) over other transition-metal ions with a hypersensitivity (detection limit 2.0 nM) in neutral buffered aqueous solutions. Notably, the coordination of chloride ion to the complex of sensor-Hg(II) brought forth that the trend in the NMR chemical shift for hydrogen and carbon atoms of the sensor was contrary to the findings in the former reports, which shows upfield shifts for the hydrogens and the alkane carbons but downfield shifts for the dansyl carbons, respectively.