(4-(羟甲基)苯基)(二苯基)甲醇 | 35960-01-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 中文名称: (4-(羟甲基)苯基)(二苯基)甲醇
• 英文名称: Diphenyl-(4-hydroxymethylphenyl)methanol
• 英文别名: (p-Hydroxymethylphenyl)diphenylmethanol；(4-(hydroxymethyl)phenyl)(diphenyl)methanol；[4-(Hydroxymethyl)phenyl]-diphenylmethanol
• CAS: 35960-01-1
• 化学式: C₂₀H₁₈O₂
• 分子量: 290.362
• InChiKey: PSCHMPVYRXXJBY-UHFFFAOYSA-N

物化性质

• 沸点：
  482.4±40.0 °C(Predicted)
• 密度：
  1.189±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (4-(羟甲基)苯基)(二苯基)甲醇 、 L-半胱氨酸盐酸盐无水物 生成 L-3-<(p-Hydroxymethyl-α,α-diphenylbenzyl)thio>alanin
  参考文献：
  名称：

  S-三苯甲基-L-半胱氨酸的结构修饰。制备一些S-（取代的三苯甲基）-L-半胱氨酸和S-三苯甲基-L-半胱氨酸的二肽。

  摘要：

  DOI：

  10.1021/jm00271a005
• 作为产物：
  描述：

  4-(二苯基羟甲基)苯甲酸 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 21.5h， 以63%的产率得到(4-(羟甲基)苯基)(二苯基)甲醇
  参考文献：
  名称：

  Triphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor Activity

  摘要：

  The human mitotic kinesin Eg5 represents a novel mitotic spindle target for cancer chemotherapy. We previously identified S-trityl-L-cysteine (STLC) and related analogues as selective potent inhibitors of Eg5. We herein report on the development of a series of 4,4,4-triphenylbutan-1-amine inhibitors derived from the STLC scaffold. This new generation systematically improves on potency: the most potent C-trityl analogues exhibit K-i(aPP) <= 10 nM and GI(50) approximate to 50 nM, comparable to results from the phase II clinical benchmark ispinesib. Crystallographic studies reveal that they adopt the same overall binding configuration as S-trityl analogues at an allosteric site formed by loop L5 of Eg5. Evaluation of their druglike properties reveals favorable profiles for future development and, in the clinical candidate ispinesib, moderate hERG and CYP inhibition. One triphenylbutanamine analogue and ispinesib possess very good bioavailability (51% and 45%, respectively), with the former showing in vivo antitumor growth activity in nude mice xenograft studies.

  DOI：

  10.1021/jm201195m

文献信息

• POLY(P-XYLYLENE)-BASED POLYMER HAVING LOW DIELECTRIC CONSTANT AND LOW-LOSS PROPERTY AND INSULATING MATERIAL, PRINTED CIRCUIT BOARD AND FUNCTIONAL ELEMENT USING THE SAME
  申请人：CHO Jae-Choon

  公开号：US20100048858A1

  公开（公告）日：2010-02-25

  The present invention relates to a poly(p-xylylene)-based polymer having a low dielectric constant suitable for low loss dielectrics (LLD), and an insulating material, a printed circuit board and a functional element using the same. More particularly, the poly(p-xylylene)-based polymer includes at least one repeat unit expressed by the following formula (1): wherein, at least one of R1, R2, R7 and R8 is independently substituted or unsubstituted C6-C20 aryl; the rest of R1 to R8 are each and independently H, substituted or unsubstituted linear C1-C3 alkyl, or substituted or unsubstituted branched C1-C3 alkyl; and n is an integer of 400 to 900.

  本发明涉及一种基于聚（对二甲苯）的聚合物，具有低介电常数，适用于低损耗介电材料（LLD），以及使用该聚合物的绝缘材料、印刷电路板和功能元件。更具体地说，聚（对二甲苯）基聚合物包括至少一个由以下公式（1）表示的重复单元： 其中，R1、R2、R7和R8中的至少一个是独立的取代或未取代的C6-C20芳基；R1到R8的其余部分分别且独立地是H、取代或未取代的线性C1-C3烷基，或取代或未取代的支链状C1-C3烷基；n是400到900的整数。
• Hydrophobe fluorierte Polymeroberflächen
  申请人：PHILIPPS-UNIVERSITÄT MARBURG

  公开号：EP2048187A1

  公开（公告）日：2009-04-15

  Die vorliegende Erfindung betrifft hydrophobe Polymeroberflächen, insbesondere superhydrophobe Polymeroberflächen, enthaltend wenigstens ein Homo- oder Copolymer, welches wenigstens eine Seitenkette mit wenigstens einer fluorsubstituierten Arylgruppe aufweist. Des weiteren betrifft die vorliegende Erfindung ein Verfahren zur Herstellung derartiger Polymeroberflächen, deren Verwendung und Polymere der allgemeinen Formel I: worin n eine ganze Zahl zwischen 10 und 4.500, bevorzugt zwischen 20 und 2.200 und besonders bevorzugt zwischen 100 und 670 ist.

  本发明涉及疏水性聚合物表面，特别是超疏水性聚合物表面，其包含至少一种均聚物或共聚物，该均聚物或共聚物具有至少一条带有至少一个氟取代芳基的侧链。此外，本发明还涉及制备此类聚合物表面的工艺、其用途以及通式 I 的聚合物： 其中 n 是介于 10 和 4500 之间的整数，最好介于 20 和 2200 之间，尤其最好介于 100 和 670 之间。
• US8829155B2
  申请人：——

  公开号：US8829155B2

  公开（公告）日：2014-09-09
• Triphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor Activity
  作者：Fang Wang、James A. D. Good、Oliver Rath、Hung Yi Kristal Kaan、Oliver B. Sutcliffe、Simon P. Mackay、Frank Kozielski

  DOI：10.1021/jm201195m

  日期：2012.2.23

  The human mitotic kinesin Eg5 represents a novel mitotic spindle target for cancer chemotherapy. We previously identified S-trityl-L-cysteine (STLC) and related analogues as selective potent inhibitors of Eg5. We herein report on the development of a series of 4,4,4-triphenylbutan-1-amine inhibitors derived from the STLC scaffold. This new generation systematically improves on potency: the most potent C-trityl analogues exhibit K-i(aPP) <= 10 nM and GI(50) approximate to 50 nM, comparable to results from the phase II clinical benchmark ispinesib. Crystallographic studies reveal that they adopt the same overall binding configuration as S-trityl analogues at an allosteric site formed by loop L5 of Eg5. Evaluation of their druglike properties reveals favorable profiles for future development and, in the clinical candidate ispinesib, moderate hERG and CYP inhibition. One triphenylbutanamine analogue and ispinesib possess very good bioavailability (51% and 45%, respectively), with the former showing in vivo antitumor growth activity in nude mice xenograft studies.
• Structural modification of S-trityl-L-cysteine. Preparation of some S-(substituted trityl)-L-cysteines and dipeptides of S-trityl-L-cysteine
  作者：Kwang Yuen Zee-Cheng、C. C. Cheng

  DOI：10.1021/jm00271a005

  日期：1972.1